Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Tim C Cao"'
Autor:
Yan Gong, Eric Bourhis, Cecilia Chiu, Scott Stawicki, Venita I DeAlmeida, Bob Y Liu, Khanhky Phamluong, Tim C Cao, Richard A D Carano, James A Ernst, Mark Solloway, Bonnee Rubinfeld, Rami N Hannoush, Yan Wu, Paul Polakis, Mike Costa
Publikováno v:
PLoS ONE, Vol 5, Iss 9, p e12682 (2010)
β-Catenin-dependent Wnt signaling is initiated as Wnt binds to both the receptor FZD and coreceptor LRP5/6, which then assembles a multimeric complex at the cytoplasmic membrane face to recruit and inactivate the kinase GSK3. The large number and se
Externí odkaz:
https://doaj.org/article/e5991f379a5147a2b9b70b45b9ce3556
Autor:
Gordon C. Jayson, Nicholas van Bruggen, Napoleone Ferrara, Olivia del Puerto, Paula Thornton, Jurjees Hasan, Karen Davies, Giovanni A. Buonaccorsi, Sarajane Ross, Tim C. Cao, Xiumin Wu, Glenn J. Pacheco, Mary Ann T. Go, Hani Bou Reslan, Sue Cheung, Lynn Hope, Caleb Roberts, Yvonne Watson, Claire L. Mitchell, Michel Friesenhahn, Franklin V. Peale, Chris J. Rose, Geoff J.M. Parker, Alan Jackson, Calvin C.K. Ho, Jed Ross, Andrew R. Clamp, Richard A.D. Carano, James P.B. O'Connor
Supplementary Data from Quantifying Antivascular Effects of Monoclonal Antibodies to Vascular Endothelial Growth Factor: Insights from Imaging
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c044431327581809ffe331a2b4700f9
https://doi.org/10.1158/1078-0432.22440574.v1
https://doi.org/10.1158/1078-0432.22440574.v1
Autor:
Gordon C. Jayson, Nicholas van Bruggen, Napoleone Ferrara, Olivia del Puerto, Paula Thornton, Jurjees Hasan, Karen Davies, Giovanni A. Buonaccorsi, Sarajane Ross, Tim C. Cao, Xiumin Wu, Glenn J. Pacheco, Mary Ann T. Go, Hani Bou Reslan, Sue Cheung, Lynn Hope, Caleb Roberts, Yvonne Watson, Claire L. Mitchell, Michel Friesenhahn, Franklin V. Peale, Chris J. Rose, Geoff J.M. Parker, Alan Jackson, Calvin C.K. Ho, Jed Ross, Andrew R. Clamp, Richard A.D. Carano, James P.B. O'Connor
CCR Translation for the Article from Quantifying Antivascular Effects of Monoclonal Antibodies to Vascular Endothelial Growth Factor: Insights from Imaging
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b15c08ae1c058cb6d4224af3e1f19d1
https://doi.org/10.1158/1078-0432.22440577
https://doi.org/10.1158/1078-0432.22440577
Autor:
Gordon C. Jayson, Nicholas van Bruggen, Napoleone Ferrara, Olivia del Puerto, Paula Thornton, Jurjees Hasan, Karen Davies, Giovanni A. Buonaccorsi, Sarajane Ross, Tim C. Cao, Xiumin Wu, Glenn J. Pacheco, Mary Ann T. Go, Hani Bou Reslan, Sue Cheung, Lynn Hope, Caleb Roberts, Yvonne Watson, Claire L. Mitchell, Michel Friesenhahn, Franklin V. Peale, Chris J. Rose, Geoff J.M. Parker, Alan Jackson, Calvin C.K. Ho, Jed Ross, Andrew R. Clamp, Richard A.D. Carano, James P.B. O'Connor
Purpose: Little is known concerning the onset, duration, and magnitude of direct therapeutic effects of anti–vascular endothelial growth factor (VEGF) therapies. Such knowledge would help guide the rational development of targeted therapeutics from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24828396fa0d9bf616db702d9622adeb
https://doi.org/10.1158/1078-0432.c.6517882.v1
https://doi.org/10.1158/1078-0432.c.6517882.v1
Autor:
Allie Maltzman, Patrick Caplazi, Wyne P. Lee, Domagoj Vucic, Joshua D. Webster, Debra L. Dugger, Juan Zhang, Baby Martin-McNulty, N. van Bruggen, Jason DeVoss, Joan M. Greve, Brent S. McKenzie, Lauri Diehl, Ivan Peng, Kim Newton, Xiumin Wu, Tim C. Cao, Surinder Jeet, Lisa J. Bernstein, Maj Hedehus, Merone Roose-Girma, Richard A.D. Carano
Publikováno v:
Cell Death and Differentiation
Necroptosis is a caspase-independent form of cell death that is triggered by activation of the receptor interacting serine/threonine kinase 3 (RIPK3) and phosphorylation of its pseudokinase substrate mixed lineage kinase-like (MLKL), which then trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24d4b49477ab1b9581c914016a9c96c5
https://doi.org/10.1038/cdd.2016.46
https://doi.org/10.1038/cdd.2016.46
Autor:
Jason H. Cheng, Douglas Den Otter, Hani Bou-Reslan, Vidusha Devasthali, Richard A.D. Carano, Emily Chan, Klaus P. Hoeflich, Anne C Clermont, Michelle Nannini, Mallika Singh, Ciara Metcalfe, Mark Merchant, Dorothy French, Joseph Castillo, Melissa R. Junttila, Tim C. Cao, William F. Forrest
Publikováno v:
Molecular Cancer Therapeutics. 14:40-47
Activating mutations in the KRAS oncogene occur in approximately 90% of pancreatic cancers, resulting in aberrant activation of the MAPK and the PI3K pathways, driving malignant progression. Significant efforts to develop targeted inhibitors of nodes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87c291cef05271b3153d12501de6733a
https://doi.org/10.1158/1535-7163.mct-14-0030
https://doi.org/10.1158/1535-7163.mct-14-0030
Autor:
Sharon E. Ungersma, Jean Michel Vernes, Lori Friedman, Liliane Robillard, Tim C. Cao, Hartmut Koeppen, Shelby K. Wyatt, Deepak Sampath, Jed Ross, Yu-Ju Gloria Meng, Napoleone Ferrara, Calvin Ho, Maresa Caunt, Richard A.D. Carano, Weilan Ye, Nick van Bruggen, Jeffrey Eastham-Anderson, Kai H. Barck, Philip Vitorino, Ulka Vijapurkar, Jason Oeh, Guanglei Zhuang, Hani Bou Reslan
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 15, Iss 7, Pp 694-711 (2013)
The phosphatidylinositol 3-kinase (PI3K) pathway is a central mediator of vascular endothelial growth factor (VEGF)-driven angiogenesis. The discovery of small molecule inhibitors that selectively target PI3K or PI3K and mammalian target of rapamycin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::012b9e017e13a17f2f1fc1f6dcf0f9bd
http://www.sciencedirect.com/science/article/pii/S1476558613800644
http://www.sciencedirect.com/science/article/pii/S1476558613800644
Autor:
Richard A.D. Carano, Laurent Salphati, Tim C. Cao, Cristine Quiason, Merry Nishimura, Emile Plise, Michelle Nannini-Pepe, Hartmut Koeppen, Alan G. Olivero, Xiaolin Zhang, Jodie Pang, Joan M. Greve, Stephen E. Gould, Bruno Alicke, Shari Lau, Sheerin K. Shahidi-Latham, Heidi S. Phillips, Leslie Lee, Linda Rangell, Timothy P. Heffron, Jonathan Cheong
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 44(12)
Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults. Limited treatment options have only marginally impacted patient survival over the past decades. The phophatidylinositol 3-kinase (PI3K) pathway, frequently altered in GBM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84449559edbc931663281cd5c5b45710
https://pubmed.ncbi.nlm.nih.gov/27638506
https://pubmed.ncbi.nlm.nih.gov/27638506
Anti-VEGF antibody therapy does not promote metastasis in genetically engineered mouse tumour models
Autor:
William F. Forrest, Ian Kasman, Patricia Hamilton, Angela McNutt, Napoleone Ferrara, Hani Bou Reslan, Calvin Ho, Anthony Lima, Jason H. Cheng, Rafael Molina, Richard A.D. Carano, Suzana S. Couto, Leisa Johnson, Oded Foreman, Kai H. Barck, Michelle Nannini, Jeffrey Eastham-Anderson, Mallika Singh, Adrian M. Jubb, Jason E. Long, Tim C. Cao
Publikováno v:
The Journal of Pathology. 227:417-430
Resistance to anti-angiogenic therapy can occur via several potential mechanisms. Unexpectedly, recent studies showed that short-term inhibition of either VEGF or VEGFR enhanced tumour invasiveness and metastatic spread in preclinical models. In an e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4bc5670683bf8357c302d05dfd68ce40
https://doi.org/10.1002/path.4053
https://doi.org/10.1002/path.4053
Autor:
Richard A.D. Carano, Ryan J. Watts, Stephen J. Tam, Tim C. Cao, Zora Modrusan, Baby Martin-McNulty, Joshua S. Kaminker, Nick van Bruggen, Robby M. Weimer, David L. Richmond
Publikováno v:
Developmental Cell. 22(2):403-417
Summary Signaling events that regulate central nervous system (CNS) angiogenesis and blood-brain barrier (BBB) formation are only beginning to be elucidated. By evaluating the gene expression profile of mouse vasculature, we identified DR6/TNFRSF21 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a74409c64970bc5e1ed0314a57d49919