Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Tim C, Clayton"'
Publikováno v:
Journal of the American College of Cardiology. 66(24)
This paper provides practical guidance on the fundamentals of design for major randomized controlled trials. Topics covered include the choice of patients, choice of treatment and control groups, choice of primary and secondary endpoints, methods of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::846600e68687371c687be53a18b76f60
https://pubmed.ncbi.nlm.nih.gov/26700838
https://pubmed.ncbi.nlm.nih.gov/26700838
Publikováno v:
Journal of the American College of Cardiology. 66(25)
As a sequel to last week's paper on the fundamentals of clinical trial design, this paper tackles related controversial issues: noninferiority trials, the value of factorial designs, the importance and challenges of strategy trials, Data Monitoring C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::053f84efb42208f125d37f5571fcf3a8
https://pubmed.ncbi.nlm.nih.gov/26718676
https://pubmed.ncbi.nlm.nih.gov/26718676
Autor:
Sudhakar, George, James, Cockburn, Tim C, Clayton, Peter, Ludman, James, Cotton, James, Spratt, Simon, Redwood, Mark, de Belder, Adam, de Belder, Jonathan, Hill, Angela, Hoye, Nick, Palmer, Sudhir, Rathore, Anthony, Gershlick, Carlo, Di Mario, David, Hildick-Smith
Publikováno v:
Journal of the American College of Cardiology. 64(24)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d352320e65802988a1e544ded2d11b32
https://pubmed.ncbi.nlm.nih.gov/25524351
https://pubmed.ncbi.nlm.nih.gov/25524351
Autor:
Marcus, Flather, June-Wha, Rhee, Derek B, Boothroyd, Eric, Boersma, Maria Mori, Brooks, Didier, Carrié, Tim C, Clayton, Nicholas, Danchin, Christian W, Hamm, Whady A, Hueb, Spencer B, King, Stuart J, Pocock, Alfredo E, Rodriguez, Patrick, Serruys, Ulrich, Sigwart, Rodney H, Stables, Mark A, Hlatky
Publikováno v:
Journal of the American College of Cardiology. 60(21)
This study sought to assess whether patient age modifies the comparative effectiveness of coronary artery bypass graft (CABG) surgery and percutaneous coronary intervention (PCI).Increasingly, CABG and PCI are performed in older patients to treat mul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a4a9553790519be4e8a2771844c9c742
https://pubmed.ncbi.nlm.nih.gov/23524208
https://pubmed.ncbi.nlm.nih.gov/23524208
Autor:
Sudhakar George, James Cockburn, Tim C. Clayton, Peter Ludman, James Cotton, James Spratt, Simon Redwood, Mark de Belder, Adam de Belder, Jonathan Hill, Angela Hoye, Nick Palmer, Sudhir Rathore, Anthony Gershlick, Carlo Di Mario, David Hildick-Smith
Publikováno v:
Journal of the American College of Cardiology. 64(24):2709-2710
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b1722b67c62eb23d28c9f825c04a3d1
Autor:
Keith A A, Fox, Tim C, Clayton, Peter, Damman, Stuart J, Pocock, Robbert J, de Winter, Jan G P, Tijssen, Bo, Lagerqvist, Lars, Wallentin
Publikováno v:
Journal of the American College of Cardiology. 55(22)
This study was designed to determine: 1) whether a routine invasive (RI) strategy reduces the long-term frequency of cardiovascular death or nonfatal myocardial infarction (MI) using a meta-analysis of individual patient data from all randomized stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::12dae26e1c2c6466b4b886852a417e08
https://pubmed.ncbi.nlm.nih.gov/21029879
https://pubmed.ncbi.nlm.nih.gov/21029879
Autor:
Ajay J Kirtane, Roxana Mehran Helen Parise, Bernard Witzenbichler, Giulio Guagliumi, Jan Z Peruga, Bruce Brodie, Dariusz Dudek, Stuart Pocock, Tim C Clayton, Vilia Tourkova, George D Dangas, Alexandra J Lansky, Gregg W Stone
Publikováno v:
Circulation. 118
Background: Bleeding complications are strongly associated with subsequent mortality among pts with ACS. The relative importance of the individual components of the composite bleeding scales used in clinical trials is poorly understood. Objectives an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::803dea9325138c4d8e70b23ef8d5b380
https://doi.org/10.1161/circ.118.suppl_18.s_1048
https://doi.org/10.1161/circ.118.suppl_18.s_1048
Autor:
Michelle O’Donoghue, Marc S Sabatine, William E Boden, Eugene Braunwald, Christopher P Cannon, Tim C Clayton, Robbert J de Winter, Keith A Fox, Bo Lagerqvist, Peter A McCullough, Sabina A Murphy, Rudolf Spacek, Eva Swahn, Lars Wallentin, Fons Windhausen
Publikováno v:
Circulation. 116
Background: Although an early invasive strategy (INV) is frequently used in patients with non-ST-elevation acute coronary syndromes (NSTEACS), some trials have shown this strategy to be associated with worse outcomes in women. We conducted a collabor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a22ef6411982fefde400231816bb6b31
https://doi.org/10.1161/circ.116.suppl_16.ii_383-b
https://doi.org/10.1161/circ.116.suppl_16.ii_383-b
Autor:
Gregg W. Stone, James H. Ware, Michel E. Bertrand, A. Michael Lincoff, Jeffrey W. Moses, E. Magnus Ohman, Harvey D. White, Frederick Feit, Antonio Colombo, Brent T. McLaurin, David A. Cox, Steven V. Manoukian, Martin Fahy, Tim C. Clayton, Roxana Mehran, Stuart J. Pocock, for the ACUITY Investigators
CONTEXT: At 30-day follow-up, patients with moderate- and high-risk acute coronary syndromes (ACS) undergoing early invasive treatment in the ACUITY trial with bivalirudin monotherapy vs heparin plus glycoprotein (GP) IIb/IIIa inhibitors had noninfer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3909afd663957102d8a117a22eb220b1
Autor:
Jan G.P. Tijssen, Bo Lagerqvist, Peter Damman, Stuart J. Pocock, Keith A.A. Fox, Robbert J. de Winter, Lars Wallentin, Tim C. Clayton
Publikováno v:
Journal of the American College of Cardiology. (19):1609-1610
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f748385be637b19e0a29b34e52108a3e