Výsledky vyhledávání - "Tim Brantley"

A novel approach to residence time distribution characterization in a mAb continuous process

Autor: Seth Madren, Sanaa Elouafiq, Kurtis Denny, Bassam Nakhle, Tim Brantley, Sarwat Khattak, Jon Bogue

Publikováno v: Biotechnology and Bioengineering. 118:3486-3498

Residence time distribution modeling of integrated perfusion to capture process can elucidate the impact of product quality excursions and filter fouling on monoclonal antibody production. In this case study, a glycosylation inhibitor and fluorescent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::836de36962c23c398e1fc01aa0daadf4
https://doi.org/10.1002/bit.27775

Zobrazit plný text záznamu

Elemental metal variance in cell culture raw materials for process risk profiling

Autor: Thomas E. Matthews, Brandon Moore, David Kolwyck, Tim Brantley, Chris Grinnell, Lisa Bareford

Publikováno v: Biotechnology Progress. 36

Elemental metals are critical raw material attributes which can impact cell culture performance and associated therapeutic protein product quality profiles. Metals such as copper and manganese act as cofactors and reagents for numerous metabolic path

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a9283db92aaa640c3e44a0ab3a0d605
https://doi.org/10.1002/btpr.3004

Zobrazit plný text záznamu

Biolayer Interferometry-based FcγRIIa binding assay for a therapeutic antibody with strong effector function

Autor: Adriana Bajardi-Taccioli, Tim Brantley, Marina Feschenko, Christine Bond, Allyson Masci, Chongfeng Xu, Svetlana Bergelson, Carl Co

Publikováno v: Analytical biochemistry. 611

FcγRIIa receptor binding is part of the mechanism of action for many therapeutic antibodies. AlphaScreen® technology and Biolayer Interferometry (BLI) are often used to assess protein-protein interactions. Recently we demonstrated that the presence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95eed7a6ffabf7ce4cd4e9c467710fd7
https://pubmed.ncbi.nlm.nih.gov/32755599

Zobrazit plný text záznamu

Discovery and Characterization of Histidine Oxidation Initiated Cross-links in an IgG1 Monoclonal Antibody

Autor: Li Zang, Zoran Sosic, Brad Stanley, Tim Brantley, Chongfeng Xu, Linda Yi, Yunqiu Chen

Publikováno v: Analytical chemistry. 89(15)

Novel cross-links between an oxidized histidine and intact histidine, lysine, or cysteine residues were discovered and characterized from high-molecular weight (HMW) fractions of an IgG1 monoclonal antibody (mAb). The mAb HMW fractions were collected

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36c950ed40ef00ab2572d93d1af069b0
https://pubmed.ncbi.nlm.nih.gov/28635253

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání