Patient-provider discordance between global assessments of disease activity in rheumatoid arthritis: a comprehensive clinical evaluation

Autor: Divya N. Challa, Zoran Kvrgic, Andrea L. Cheville, Cynthia S. Crowson, Tim Bongartz, Thomas G. Mason, Eric L. Matteson, Clement J. Michet, Scott T. Persellin, Daniel E. Schaffer, Theresa L. Wampler Muskardin, Kerry Wright, John M. Davis

Publikováno v: Arthritis Research & Therapy, Vol 19, Iss 1, Pp 1-14 (2017)

Abstract Background Discordance between patients with rheumatoid arthritis (RA) and their rheumatology health care providers is a common and important problem. The objective of this study was to perform a comprehensive clinical evaluation of patient-

Externí odkaz: https://doaj.org/article/b6a3570d4ad14e1b9689b22f72025a3d

Toward Individualized Prediction of Response to Methotrexate in Early Rheumatoid Arthritis

Autor: Elena, Myasoedova, Arjun P, Athreya, Cynthia S, Crowson, John M, Davis, Kenneth J, Warrington, Robert C, Walchak, Erin, Carlson, Krishna R, Kalari, Tim, Bongartz, Paul P, Tak, Ronald F, van Vollenhoven, Leonid, Padyukov, Paul, Emery, Ann, Morgan, Liewei, Wang, Richard M, Weinshilboum, Eric L, Matteson

Publikováno v: Arthritis Care and Research. John Wiley and Sons Inc.
Pharmacogenetics of Methotrexate in Rheumatoid Arthritis Consortium 2021, ' Toward Individualized Prediction of Response to Methotrexate in Early Rheumatoid Arthritis : A Pharmacogenomics-Driven Machine Learning Approach ', Arthritis Care and Research . https://doi.org/10.1002/acr.24834

Objective: To test the ability of machine learning (ML) approaches with clinical and genomic biomarkers to predict methotrexate treatment response in patients with early rheumatoid arthritis (RA). Methods: Demographic, clinical, and genomic data from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f3880bb08dd64297138e59d016c7a69
https://doi.org/10.1002/acr.24834

Genome-wide association study of response to methotrexate in early rheumatoid arthritis patients

Autor: Athina Spiliopoulou, Paul M. McKeigue, Peter Orchard, Costantino Pitzalis, Suzanne M M Verstappen, John D. Isaacs, Richard M. Weinshilboum, Ronald F van Vollenhoven, Donna K. Arnett, Leonid Padyukov, John C. Taylor, Jackie L Nam, Jonathan Massey, Anne Barton, Jianmei Wang, Heather J. Cordell, Jennifer H. Barrett, Stella Aslibekyan, Ian C. Scott, Paul P. Tak, Marco Colombo, Iain B. McInnes, Borbala Mifsud, Darren Plant, Michael R. Barnes, Paul Emery, Michael D Morgan, Duncan Porter, Sarah Twigg, Jane E. Freeston, Michiaki Kubo, Tim Bongartz, Felix Agakov, Andrew P. Cope, Ann W. Morgan, Maria J. H. de Hair, Jenna L. Strathdee, S. Louis Bridges, Taisei Mushiroda

Publikováno v: Taylor, J C, Bongartz, T, Massey, J, Mifsud, B, Spiliopoulou, A, Scott, I C, Wang, J, Morgan, M, Plant, D, Colombo, M, Orchard, P, Twigg, S, McInnes, I B, Porter, D, Freeston, J, Nam, J L, Cordell, H J, Issacs, J D, Strathdee, J L, Arnett, D, De Hair, M J H, Tak, P P, Aslibekyan, S, van Vollenhoven, R F, Padyukov, L, Bridges, S L, Pitzalis, C, Cope, A P, Verstappen, S, Emery, P, Barnes, M R, Agakov, F, McKeigue, P M, Mushiroda, T, Kubo, M, Weinshilboum, R M, Barton, A, Morgan, A W & Barrett, J H 2018, ' Genome-wide Association Study of Response to Methotrexate in Early Rheumatoid Arthritis Patients ', Pharmacogenomics Journal . https://doi.org/10.1038/s41397-018-0025-5
2018, ' Genome-wide Association Study of Response to Methotrexate in Early Rheumatoid Arthritis Patients ', Pharmacogenomics Journal . https://doi.org/10.1038/s41397-018-0025-5

Methotrexate (MTX) monotherapy is a common first treatment for rheumatoid arthritis (RA), but many patients do not respond adequately. In order to identify genetic predictors of response, we have combined data from two consortia to carry out a genome

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::869682497c599f955a81cdf275697869
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85046847176&origin=inward

TCL1A Single-Nucleotide Polymorphisms and Estrogen-Mediated Toll-Like Receptor-MYD88–Dependent Nuclear Factor-κB Activation: Single-Nucleotide Polymorphism– and Selective Estrogen Receptor Modulator–Dependent Modification of Inflammation and Immune Response

Autor: James N. Ingle, Taisei Mushiroda, Tim Bongartz, Paul E. Goss, Krishna R. Kalari, Richard M. Weinshilboum, Ming Fen Ho, Michiaki Kubo, Liewei Wang, Lois E. Shepherd

Publikováno v: Molecular Pharmacology. 92:175-184

In a previous genome-wide association study (GWAS) for musculoskeletal adverse events during aromatase inhibitor therapy for breast cancer, we reported that single nucleotide polymorphisms (SNPs) near the TCL1A gene were associated with this adverse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2df1dd8eaaeabffcd9a2ae33a2a9360
https://doi.org/10.1124/mol.117.108340

Dr. Elfishawi, et al reply

Autor: Cynthia S. Crowson, Eric L. Matteson, Tim Bongartz, Mohanad M. Elfishawi

Publikováno v: The Journal of Rheumatology. 48:468.2-468

To the Editor: We thank Huang and colleagues1 for their interest in our study on the changes in the presentation of incident gout and the risk of subsequent flare1. We reported changes over time in gout presentation with podagra becoming less frequen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6d034d0923222f01df1e57485efc4fea
https://doi.org/10.3899/jrheum.201218