Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Tim Beißert"'
Autor:
Ayşegül Yıldız, Aida Hasani, Tina Hempel, Nina Köhl, Aline Beicht, René Becker, Stefanie Hubich-Rau, Martin Suchan, Marco A. Poleganov, Ugur Sahin, Tim Beissert
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 2, Pp 102162- (2024)
The co-delivery of microRNAs (miRNAs) and protein-coding RNA presents an opportunity for a combined approach to gene expression and gene regulation for therapeutic applications. Protein delivery is established using long mRNA, self-, and trans-amplif
Externí odkaz:
https://doaj.org/article/8d3f6bfef2ca43eca17d626631e56ca1
Publikováno v:
Viruses, Vol 16, Iss 4, p 503 (2024)
Replicating RNA, including self-amplifying RNA (saRNA) and trans-amplifying RNA (taRNA), holds great potential for advancing the next generation of RNA-based vaccines. Unlike in vitro transcribed mRNA found in most current RNA vaccines, saRNA or taRN
Externí odkaz:
https://doaj.org/article/33f7b923942443fe854b4bcfe3326bf0
Autor:
Christin Schmidt, Erik Haefner, Julia Gerbeth, Tim Beissert, Ugur Sahin, Mario Perkovic, Barbara S. Schnierle
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 28, Iss , Pp 743-754 (2022)
The arthritogenic alphavirus, chikungunya virus (CHIKV), is now present in almost 100 countries worldwide. Further spread is very likely, which raises public health concerns. CHIKV infections cause fever and arthralgia, which can be debilitating and
Externí odkaz:
https://doaj.org/article/3eab765183b54a88a514b3e5df52a8ac
Autor:
Christin Schmidt, Florian D. Hastert, Julia Gerbeth, Tim Beissert, Ugur Sahin, Mario Perkovic, Barbara S. Schnierle
Publikováno v:
Vaccines, Vol 10, Iss 9, p 1374 (2022)
Alphaviruses such as the human pathogenic chikungunya virus (CHIKV) and Ross River virus (RRV) can cause explosive outbreaks raising public health concerns. However, no vaccine or specific antiviral treatment is yet available. We recently established
Externí odkaz:
https://doaj.org/article/1248d33fb49a4a7cb963048bb93ccafe
Autor:
Xiaomin Zheng, Anita Seshire, Brigitte Rüster, Gesine Bug, Tim Beissert, Elena Puccetti, Dieter Hoelzer, Reinhard Henschler, Martin Ruthardt
Publikováno v:
Haematologica, Vol 92, Iss 3 (2007)
Background and Objectives Stem cells play an important role in the pathogenesis and maintenance of most malignant tumors. Acute myeloid leukemia (AML) is a stem cell disease. The inefficient targeting of the leukemic stem cells (LSC) is considered re
Externí odkaz:
https://doaj.org/article/7cec1f0672314af4990838aac3806bf4
Autor:
Mario Perkovic, Stefanie Gawletta, Tina Hempel, Silke Brill, Evelin Nett, Ugur Sahin, Tim Beissert
Publikováno v:
Molecular Therapy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0346b160c1ae8f591fbf158217f734c8
https://doi.org/10.1016/j.ymthe.2023.01.019
https://doi.org/10.1016/j.ymthe.2023.01.019
Autor:
Diana Barea Roldan, Christoph Rohde, Christoph Hartmann, Ugur Sahin, Michael Koslowski, Tim Beißert, Giuseppe Cagna, Stefanie Hubich-Rau, Claudia Paret, Özlem Türeci, Matthias Grimmler, Stefan Wöll
Publikováno v:
Oncotarget
PLAC1 (placenta enriched 1) is a mammalian trophoblast-specific protein. Aberrant expression of PLAC1 is observed in various human cancers, where it is involved in the motility, migration, and invasion of tumor cells, which are associated with the ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a34a812ea4b6675ffeae54d40cf2c3f7
https://doi.org/10.18632/oncotarget.27582
https://doi.org/10.18632/oncotarget.27582
Autor:
Mario Perkovic, Silke Brill, Tina Hempel, Erik Haefner, Tim Beissert, Özlem Türeci, René Becker, Stephanie Erbar, Kerstin C. Walzer, Annette B. Vogel, Ugur Sahin
Publikováno v:
Mol Ther
Here, we present a potent RNA vaccine approach based on a novel bipartite vector system using trans-amplifying RNA (taRNA). The vector cassette encoding the vaccine antigen originates from an alphaviral self-amplifying RNA (saRNA), from which the rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::842ba511c356f2236fb9595eca9e338d
https://doi.org/10.1016/j.ymthe.2019.09.009
https://doi.org/10.1016/j.ymthe.2019.09.009
Autor:
Valesca Bukur, Martin Löwer, Andreas Kuhn, Lena M. Kranz, Orlandini Von Niessen Alexandra, Marco Poleganov, Corina Rechner, Tim Beissert, Britta Vallazza, Mustafa Diken, Stephanie Fesser, Ugur Sahin, Arianne Plaschke, Özlem Türeci
Publikováno v:
Molecular therapy : the journal of the American Society of Gene Therapy. 27(4)
Synthetic mRNA has emerged as a powerful tool for the transfer of genetic information, and it is being explored for a variety of therapeutic applications. Many of these applications require prolonged intracellular persistence of mRNA to improve bioav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c4b2c50609a669d737e36d4ba4129d9
https://pubmed.ncbi.nlm.nih.gov/30638957
https://pubmed.ncbi.nlm.nih.gov/30638957
Autor:
Sonja Witzel, Leonard Kaps, Tim Beissert, Christian Grunwitz, Yasmin Abassi, Patricia Gomes, Heinrich Haas, Sebastian Rosigkeit, Geethanjali Pickert, Fulvia Vascotto, Martin Meng, Jasmin Röder, Andreas Kuhn, Mustafa Diken, Andreas Kreft, Rosario Heck, Ugur Sahin, Nina Hayduk, Detlef Schuppan, Kira Ziegler, Ernesto Bockamp
Publikováno v:
Molecular pharmaceutics. 15(9)
Targeting mRNA to eukaryotic cells is an emerging technology for basic research and provides broad applications in cancer immunotherapy, vaccine development, protein replacement, and in vivo genome editing. Although a plethora of nanoparticles for ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b618edac37266dbedb6cfa87bdc5ea81
https://pubmed.ncbi.nlm.nih.gov/30028629
https://pubmed.ncbi.nlm.nih.gov/30028629