Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Tim, van Opijnen"'
Publikováno v:
JACS Au, Vol 4, Iss 7, Pp 2484-2491 (2024)
Externí odkaz:
https://doaj.org/article/1179e2c6dcb043139ddb8c4dc7c7d1e1
Autor:
Indu Warrier, Ariana Perry, Sara M Hubbell, Matthew Eichelman, Tim van Opijnen, Michelle M Meyer
Publikováno v:
PLoS Genetics, Vol 20, Iss 3, p e1011188 (2024)
Bacteria have evolved complex transcriptional regulatory networks, as well as many diverse regulatory strategies at the RNA level, to enable more efficient use of metabolic resources and a rapid response to changing conditions. However, most RNA-base
Externí odkaz:
https://doaj.org/article/151960e4dc77487cab7632fd5eb55152
Autor:
Tina H. Dao, Haley Echlin, Abigail McKnight, Enolia S. Marr, Julia Junker, Qidong Jia, Randall Hayden, Tim van Opijnen, Ralph R. Isberg, Vaughn S. Cooper, Jason W. Rosch
Publikováno v:
mBio, Vol 15, Iss 2 (2024)
ABSTRACT Streptococcus pneumoniae is a major human pathogen of global health concern and the rapid emergence of antibiotic resistance poses a serious public health problem worldwide. Fluoroquinolone resistance in S. pneumoniae is an intriguing case b
Externí odkaz:
https://doaj.org/article/10335ee40e3a4874ba67dd41ae6ffedc
Publikováno v:
PLoS Pathogens, Vol 19, Iss 6, p e1010928 (2023)
Phage have gained renewed interest as an adjunctive treatment for life-threatening infections with the resistant nosocomial pathogen Acinetobacter baumannii. Our understanding of how A. baumannii defends against phage remains limited, although this i
Externí odkaz:
https://doaj.org/article/87e37265984643ffbd503e68b5af9ce6
Autor:
Dmitry Leshchiner, Federico Rosconi, Bharathi Sundaresh, Emily Rudmann, Luisa Maria Nieto Ramirez, Andrew T. Nishimoto, Stephen J. Wood, Bimal Jana, Noemí Buján, Kaicheng Li, Jianmin Gao, Matthew Frank, Stephanie M. Reeve, Richard E. Lee, Charles O. Rock, Jason W. Rosch, Tim van Opijnen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
A lack of understanding in the development and emergence of antimicrobial resistance presents as a problem for accurate infection diagnosis and treatment. Here, authors utilize Streptococcus pneumoniae and build a genome-wide atlas to understand the
Externí odkaz:
https://doaj.org/article/79f7f04a405b4d6d8aab8145e4e451c5
Autor:
Anna J. Hooppaw, Jenna C. McGuffey, Gisela Di Venanzio, Juan C. Ortiz-Marquez, Brent S. Weber, Tasia Joy Lightly, Tim van Opijnen, Nichollas E. Scott, Silvia T. Cardona, Mario F. Feldman
Publikováno v:
mBio, Vol 13, Iss 3 (2022)
ABSTRACT The opportunistic pathogen Acinetobacter baumannii is responsible for a wide range of infections that are becoming increasingly difficult to treat due to extremely high rates of multidrug resistance. Acinetobacter’s pathogenic potential is
Externí odkaz:
https://doaj.org/article/30f123d366be48099dc72ea13e663c47
Autor:
Hector S Alvarez-Manzo, Robert K Davidson, Jasper Van Cauwelaert de Wyels, Katherine L Cotten, Benjamin H Nguyen, Melody Xiao, Zeyu Zhu, Jon Anthony, Tim van Opijnen, Kimberly Michele Davis
Publikováno v:
PLoS Pathogens, Vol 18, Iss 5, p e1010556 (2022)
Antibiotic tolerance is typically associated with a phenotypic change within a bacterial population, resulting in a transient decrease in antibiotic susceptibility that can contribute to treatment failure and recurrent infections. Although tolerant c
Externí odkaz:
https://doaj.org/article/bf7df879df3345109d55bb876677c920
Autor:
Edward Geisinger, Nadav J. Mortman, Yunfei Dai, Murat Cokol, Sapna Syal, Andrew Farinha, Delaney G. Fisher, Amy Y. Tang, David W. Lazinski, Stephen Wood, Jon Anthony, Tim van Opijnen, Ralph R. Isberg
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
A unique cell envelope contributes to the antibiotic resistance of the pathogen Acinetobacter baumannii. Here, Geisinger et al. identify A. baumannii mutants with altered antibiotic susceptibility, infer the function of uncharacterized proteins invol
Externí odkaz:
https://doaj.org/article/c02ae759b9cd41e7bac28dc223d59326
Autor:
Zeyu Zhu, Defne Surujon, Juan C. Ortiz-Marquez, Wenwen Huo, Ralph R. Isberg, José Bento, Tim van Opijnen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Bacterial transcriptomic data have been used to predict antibiotic susceptibility in a species- or antibiotic-specific manner. Here, the authors show that global transcriptional disorder is a common stress response in bacteria with low fitness, and p
Externí odkaz:
https://doaj.org/article/ef0fe239e15245d990fc0ccfb009ce26
Autor:
Defne Surujon, Tim van Opijnen
Publikováno v:
BMC Bioinformatics, Vol 21, Iss 1, Pp 1-8 (2020)
Abstract Background Omics-profiling is a collection of increasingly prominent approaches that result in large-scale biological datasets, for instance capturing an organism’s behavior and response in an environment. It can be daunting to manually an
Externí odkaz:
https://doaj.org/article/2862f91d887544c0a7d78f9127e456ed