Modification of Aβ Peptide Aggregation via Covalent Binding of a Series of Ru(III) Complexes

Autor: Luiza M. F. Gomes, Janaina C. Bataglioli, Allison J. Jussila, Jason R. Smith, Charles J. Walsby, Tim Storr

Publikováno v: Frontiers in Chemistry, Vol 7 (2019)

Alzheimer's disease (AD) is the most common form of dementia, leading to loss of cognition, and eventually death. The disease is characterized by the formation of extracellular aggregates of the amyloid-beta (Aβ) peptide and neurofibrillary tangles

Externí odkaz: https://doaj.org/article/c5e0aadf61934d61894902cf747edfd4

A role for bioinorganic chemistry in the reactivation of mutant p53 in cancer

Autor: Jessica J. Miller, Kalvin Kwan, Christian Gaiddon, Tim Storr

Publikováno v: Journal of Biological Inorganic Chemistry
Journal of Biological Inorganic Chemistry, 2022, 27 (4-5), pp.393-403. ⟨10.1007/s00775-022-01939-2⟩

International audience; Metal ion dysregulation has been implicated in a number of diseases from neurodegeneration to cancer. While defective metal ion transport mechanisms are known to cause specific diseases of genetic origin, the role of metal dys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65dacc575a66b91ad5dd21ed9e2fbeea
https://doi.org/10.1007/s00775-022-01939-2

Inhibition of p53 protein aggregation as a cancer treatment strategy

Autor: Kalvin Kwan, Omar Castro-Sandoval, Christian Gaiddon, Tim Storr

Publikováno v: Current opinion in chemical biology. 72

The p53 protein plays a critical role in the prevention of genome mutations in the body, however, this protein is frequently mutated in cancer and almost all cancers exhibit malfunction along the p53 pathway. In addition to a loss of activity, mutant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cd8a731d5ff774a36ff59b9471b41c8
https://pubmed.ncbi.nlm.nih.gov/36436275

Multifunctional compounds for the treatment of Alzheimer’s disease

Autor: Tim Storr

Publikováno v: Canadian Journal of Chemistry. 99:1-9

Alzheimer’s disease (AD) is the most common form of dementia, and the prevalence of this currently untreatable disease is expected to rise in step with increased global life expectancy. AD is a multifaceted disorder commonly characterized by extrac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5e69bf4eccb183f1035a943ed1b7e5c7
https://doi.org/10.1139/cjc-2020-0279

Exciton Coupling in Redox-Active Salen based Self-Assembled Metallacycles

Autor: Tim Storr, Sébastien Goeb, Magali Allain, Gregory A. MacNeil, Vincent Carré, Khrystyna Herasymchuk, Marc Sallé, Frédéric Aubriet, Daniel B. Leznoff

Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany). 27(65)

The incorporation of a redox-active nickel salen complex into supramolecular structures was explored via coordination-driven self-assembly with homobimetallic ruthenium complexes (bridged by oxalato or 5,8-dihydroxy-1,4-naphthoquinato ligands). The s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f0ea2e879eda9a5c44e593d2fb5e7b0
https://pubmed.ncbi.nlm.nih.gov/34595790