Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Tim, Spector"'
Autor:
Claire T. McEvoy, Amy Jennings, Claire J. Steves, Alexander Macgregor, Tim Spector, Aedin Cassidy
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-10 (2024)
Abstract Background Plant-based diets may provide protection against cognitive decline and Alzheimer’s disease, but observational data have not been consistent. Previous studies include early life confounding from socioeconomic conditions and genet
Externí odkaz:
https://doaj.org/article/3115e47d2cd94efe969709565d10480c
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-8 (2024)
Abstract Background Genomic heterozygosity has been shown to confer a health advantage in humans and play a protective role in complex diseases. Given osteoarthritis (OA) is a highly polygenic disease, we set out to determine if an association exists
Externí odkaz:
https://doaj.org/article/ac8457d4e32848b7824fdaaaf8c9b23d
Autor:
Marc F. Österdahl, Ronan Whiston, Carole H. Sudre, Francesco Asnicar, Nathan J. Cheetham, Aitor Blanco Miguez, Vicky Bowyer, Michela Antonelli, Olivia Snell, Liane dos Santos Canas, Christina Hu, Jonathan Wolf, Cristina Menni, Michael Malim, Deborah Hart, Tim Spector, Sarah Berry, Nicola Segata, Katie Doores, Sebastien Ourselin, Emma L. Duncan, Claire J. Steves
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Whilst most individuals with SARS-CoV-2 infection have relatively mild disease, managed in the community, it was noted early in the pandemic that individuals with cardiovascular risk factors were more likely to experience severe acute diseas
Externí odkaz:
https://doaj.org/article/f8140cf6129b4dc1aa089ecc0e0465f6
Autor:
Yiqing Wang, Wenjie Ma, Raaj Mehta, Long H. Nguyen, Mingyang Song, David A. Drew, Francesco Asnicar, Curtis Huttenhower, Nicola Segata, Jonathan Wolf, Tim Spector, Sarah Berry, Kyle Staller, Andrew T. Chan
Publikováno v:
Gut Microbes, Vol 15, Iss 2 (2023)
ABSTRACTThe role of diet and the gut microbiome in the etiopathogenesis of irritable bowel syndrome (IBS) is not fully understood. Therefore, we investigated the interplay between dietary risk factors and gut microbiota in IBS subtypes using a food f
Externí odkaz:
https://doaj.org/article/33d24307162a4f43a499633f22fc3ddb
Autor:
Thomas Liechti, Sofie Van Gassen, Margaret Beddall, Reid Ballard, Yaser Iftikhar, Renguang Du, Thiagarajan Venkataraman, David Novak, Massimo Mangino, Stephen Perfetto, H. Benjamin Larman, Tim Spector, Yvan Saeys, Mario Roederer
Publikováno v:
Cell Reports: Methods, Vol 3, Iss 10, Pp 100619- (2023)
Summary: High-dimensional flow cytometry is the gold standard to study the human immune system in large cohorts. However, large sample sizes increase inter-experimental variation because of technical and experimental inaccuracies introduced by batch
Externí odkaz:
https://doaj.org/article/2e8e1fccf31b420da4db9601aa01dcf0
Autor:
Aoife Murray, Gillian Gough, Ana Cindrić, Frano Vučković, David Koschut, Vincenzo Borelli, Dražen J. Petrović, Ana Bekavac, Ante Plećaš, Valentina Hribljan, Reinhard Brunmeir, Julija Jurić, Maja Pučić-Baković, Anita Slana, Helena Deriš, Azra Frkatović, Jűrgen Groet, Niamh L. O’Brien, Hong Yu Chen, Yee Jie Yeap, Frederic Delom, Steven Havlicek, Luke Gammon, Sarah Hamburg, Carla Startin, Hana D’Souza, Dinko Mitrečić, Mijana Kero, Ljubica Odak, Božo Krušlin, Željka Krsnik, Ivica Kostović, Jia Nee Foo, Yuin-Han Loh, Norris Ray Dunn, Susana de la Luna, Tim Spector, Ingeborg Barišić, Michael S.C. Thomas, Andre Strydom, Claudio Franceschi, Gordan Lauc, Jasminka Krištić, Ivan Alić, Dean Nižetić
Publikováno v:
EBioMedicine, Vol 94, Iss , Pp 104692- (2023)
Summary: Background: People with Down syndrome (DS) show clinical signs of accelerated ageing. Causative mechanisms remain unknown and hypotheses range from the (essentially untreatable) amplified-chromosomal-instability explanation, to potential act
Externí odkaz:
https://doaj.org/article/fccbd6f8ccf04865a74224623e30be79
Autor:
Anika Mijakovac, Azra Frkatović, Maja Hanić, Jelena Ivok, Marina Martinić Kavur, Maja Pučić-Baković, Tim Spector, Vlatka Zoldoš, Massimo Mangino, Gordan Lauc
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Immunoglobulin G is posttranslationally modified by the addition of complex N-glycans affecting its function and mediating inflammation at multiple levels. IgG glycome composition changes with age and health in a predictive pattern, presumably due to
Externí odkaz:
https://doaj.org/article/2143403fbdb3443e815d3b9629b792b8
Publikováno v:
BMC Medicine, Vol 19, Iss 1, Pp 1-12 (2021)
Abstract Background Although the pathophysiology of cognitive decline is multifactorial, and modifiable by lifestyle, the evidence for the role of diet on cognitive function is still accumulating, particularly the potentially preventive role of const
Externí odkaz:
https://doaj.org/article/0e008f59fe874a51af2e2d25a0e48b27
Publikováno v:
Mail on Sunday. 11/10/2024, p43. 3p.
Autor:
Helena Deriš, Domagoj Kifer, Ana Cindrić, Tea Petrović, Ana Cvetko, Irena Trbojević-Akmačić, Ivana Kolčić, Ozren Polašek, Louise Newson, Tim Spector, Cristina Menni, Gordan Lauc
Publikováno v:
iScience, Vol 25, Iss 3, Pp 103897- (2022)
Summary: Gonadal hormones affect immunoglobulin G (IgG) glycosylation, and the more proinflammatory IgG glycome composition might be one of the molecular mechanisms behind the increased proinflammatory phenotype in perimenopause. Using ultra-high-per
Externí odkaz:
https://doaj.org/article/85e9d0d3a95a4655b1cac2cde739efca