Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Tim, Rasmusson"'
Autor:
Richard Wang, Camilla Ascanelli, Ahmed Abdelbaki, Alex Fung, Tim Rasmusson, Iacovos Michaelides, Karen Roberts, Catherine Lindon
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Wang et al develop tools to target the mitotic regulator AURKA by synthesising PROTACs based on the inhibitor MLN8237. They find that the new PROTAC compound efficiently clears cytoplasmic and mitotic spindle-associated AURKA but does not eliminate A
Externí odkaz:
https://doaj.org/article/465f730a69b64dfb9fe0a36d0ac01429
Autor:
Karen Roberts, Iacovos N Michaelides, Richard Wang, Ahmed Abdelbaki, Catherine Lindon, Alex Fung, Camilla Ascanelli, Tim Rasmusson
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Funder: AstraZeneca; doi: https://doi.org/10.13039/100004325
Targeted protein degradation tools are becoming a new therapeutic modality, allowing small molecule ligands to be reformulated as heterobifunctional molecules (PROteolysis Targeting Ch
Targeted protein degradation tools are becoming a new therapeutic modality, allowing small molecule ligands to be reformulated as heterobifunctional molecules (PROteolysis Targeting Ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4175155678a9205e311961c0ad9cf506
Autor:
Tim Rasmusson, Nello Mainolfi
Targeted protein degradation is arguably one of the most exciting novel therapeutic modalities in drug discovery. Moving away from occupancy-based pharmacology models and their challenges with selectivity, on/off target toxicities, and PK–PD limita
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d767971c7bee7518615d0646da016585
https://doi.org/10.1016/bs.armc.2017.08.005
https://doi.org/10.1016/bs.armc.2017.08.005
Autor:
Jeffrey A, Pfefferkorn, Meihua, Tu, Kevin J, Filipski, Angel, Guzman-Perez, Jianwei, Bian, Gary E, Aspnes, Matthew F, Sammons, Wei, Song, Jian-Cheng, Li, Christopher S, Jones, Leena, Patel, Tim, Rasmusson, Dongxiang, Zeng, Kapil, Karki, Michael, Hamilton, Richard, Hank, Karen, Atkinson, John, Litchfield, Robert, Aiello, Levenia, Baker, Nicole, Barucci, Patricia, Bourassa, Francis, Bourbonais, Francis, Bourbounais, Theresa, D'Aquila, David R, Derksen, Margit, MacDougall, Alan, Robertson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:7100-7105
Glucokinase activators represent a promising potential treatment for patients with Type 2 diabetes. Herein, we report the identification and optimization of a series of novel indazole and pyrazolopyridine based activators leading to the identificatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::decea8e508a8ec84ae478bd0cc878d20
https://doi.org/10.1016/j.bmcl.2012.09.082
https://doi.org/10.1016/j.bmcl.2012.09.082
Publikováno v:
Angewandte Chemie. 120:7117-7120
The p–p stacking and edge–face contacts between aromatic groups occupy prominent positions among noncovalent interactions, with helicity being one the most significant kinds of supramolecular organization driven by these interactions. Apart from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35add09604e23ca9070c7fafb81c5460
https://doi.org/10.1002/ange.200801991
https://doi.org/10.1002/ange.200801991
Publikováno v:
Angewandte Chemie International Edition. 47:7009-7012
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a3f36cb4a429fcb8937ee6c354bb832
https://doi.org/10.1002/anie.200801991
https://doi.org/10.1002/anie.200801991
Autor:
Sarah de Groot, Jeremy Bezaire, Jason Yaeck, Christine How, Tim Rasmusson, Eric Jervis, J. Guy Guillemette, Gary I. Dmitrienko, Geneviève Labbé
Publikováno v:
Protein Expression and Purification. 51:110-119
The Class II fructose 1,6-bisphosphate aldolase from the Rice Blast causative agent Magnaporthe grisea was subcloned in the Escherichia coli vector pT7-7. The enzyme was overexpressed using fed-batch fermentation in a small bench-top reactor. A total
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df24db2dbeff91dc33d8b555125f550d
https://doi.org/10.1016/j.pep.2006.06.020
https://doi.org/10.1016/j.pep.2006.06.020
Autor:
Jeffrey A. Pfefferkorn, Meihua Tu, Kevin J. Filipski, Angel Guzman-Perez, Jianwei Bian, Gary E. Aspnes, Matthew F. Sammons, Wei Song, Jian-Cheng Li, Christopher S. Jones, Leena Patel, Tim Rasmusson, Dongxiang Zeng, Kapil Karki, Michael Hamilton, Richard Hank, Karen Atkinson, John Litchfield, Robert Aiello, Levenia Baker, Nicole Barucci, Patricia Bourassa, Francis Bourbonais, Theresa D’Aquila, David R. Derksen, Margit MacDougall, Alan Robertson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:5022
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e273925fb9d66346c7b51be62c5e68cd
https://doi.org/10.1016/j.bmcl.2013.06.063
https://doi.org/10.1016/j.bmcl.2013.06.063