Zobrazeno 1 - 10
of 246
pro vyhledávání: '"Tim, Magnus"'
Autor:
Thomas Eden, Alessa Z. Schaffrath, Janusz Wesolowski, Tobias Stähler, Natalie Tode, Nathalie Richter, Waldemar Schäfer, Julia Hambach, Irm Hermans-Borgmeyer, Jannis Woens, Camille M. Le Gall, Sabrina Wendler, Christian Linke-Winnebeck, Martina Stobbe, Iwona Budnicki, Amelie Wanney, Yannic Heitz, Lena Schimmelpfennig, Laura Schweitzer, Dennis Zimmer, Erik Stahl, Fabienne Seyfried, Anna J. Gebhardt, Lynn Dieckow, Kristoffer Riecken, Boris Fehse, Peter Bannas, Tim Magnus, Martijn Verdoes, Carl G. Figdor, Klaus F. Hartlepp, Hubertus Schleer, Jonas Füner, Nicola M. Tomas, Friedrich Haag, Björn Rissiek, Anna M. Mann, Stephan Menzel, Friedrich Koch-Nolte
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Due to their exceptional solubility and stability, nanobodies have emerged as powerful building blocks for research tools and therapeutics. However, their generation in llamas is cumbersome and costly. Here, by inserting an engineered llama
Externí odkaz:
https://doaj.org/article/06c0fed6be0b4da1ae092b68397ac332
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Microglia play a crucial role in maintaining homeostasis of the central nervous system and they are actively involved in shaping the brain’s inflammatory response to stress. Among the multitude of involved molecules, purinergic receptors and enzyme
Externí odkaz:
https://doaj.org/article/30154e31ac5e447c84e47ea15af4b30f
Autor:
Stephan Menzel, Yinghui Duan, Julia Hambach, Birte Albrecht, Dorte Wendt-Cousin, Riekje Winzer, Eva Tolosa, Anne Rissiek, Andreas H. Guse, Friedrich Haag, Tim Magnus, Friedrich Koch-Nolte, Björn Rissiek
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
CD39 is the major enzyme controlling the levels of extracellular adenosine triphosphate (ATP) via the stepwise hydrolysis of ATP to adenosine diphosphate (ADP) and adenosine monophosphate (AMP). As extracellular ATP is a strong promoter of inflammati
Externí odkaz:
https://doaj.org/article/ede936c25e8b4acd80c5bcc8d2044e79
Autor:
Alejandro Montilla, Alazne Zabala, Marco Er-Lukowiak, Björn Rissiek, Tim Magnus, Noelia Rodriguez-Iglesias, Amanda Sierra, Carlos Matute, María Domercq
Publikováno v:
Cell Death and Disease, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract In multiple sclerosis and the experimental autoimmune encephalomyelitis (EAE) model, both resident microglia and infiltrating macrophages contribute to demyelination as well as spontaneous remyelination. Nevertheless, the specific roles of m
Externí odkaz:
https://doaj.org/article/6a0c15c469b04ffda3b3e6378ecc1f7d
Autor:
Maximilian Wilmes, Carolina Pinto Espinoza, Peter Ludewig, Joschi Stabernack, Arthur Liesz, Annette Nicke, Mathias Gelderblom, Christian Gerloff, Simonetta Falzoni, Eva Tolosa, Francesco Di Virgilio, Björn Rissiek, Nikolaus Plesnilla, Friedrich Koch-Nolte, Tim Magnus
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-14 (2022)
Abstract Background Previous studies have demonstrated that purinergic receptors could be therapeutic targets to modulate the inflammatory response in multiple models of brain diseases. However, tools for the selective and efficient targeting of thes
Externí odkaz:
https://doaj.org/article/42a72dde94804cbaafa23cc1ebad1ef5
Autor:
Marius Piepke, Bettina H. Clausen, Peter Ludewig, Jonas H. Vienhues, Tanja Bedke, Ehsan Javidi, Björn Rissiek, Larissa Jank, Leonie Brockmann, Inga Sandrock, Karoline Degenhardt, Alina Jander, Vanessa Roth, Ines S. Schädlich, Immo Prinz, Richard A. Flavell, Yasushi Kobayashi, Thomas Renné, Christian Gerloff, Samuel Huber, Tim Magnus, Mathias Gelderblom
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-16 (2021)
Abstract Background Lymphocytes have dichotomous functions in ischemic stroke. Regulatory T cells are protective, while IL-17A from innate lymphocytes promotes the infarct growth. With recent advances of T cell-subtype specific transgenic mouse model
Externí odkaz:
https://doaj.org/article/84eccf40e2484f5c8eb8bfa924fd98ed
Autor:
Enja Schneider, Riekje Winzer, Anne Rissiek, Isabell Ricklefs, Catherine Meyer-Schwesinger, Franz L. Ricklefs, Andreas Bauche, Jochen Behrends, Rudolph Reimer, Santra Brenna, Hauke Wasielewski, Melchior Lauten, Björn Rissiek, Berta Puig, Filippo Cortesi, Tim Magnus, Ralf Fliegert, Christa E. Müller, Nicola Gagliani, Eva Tolosa
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Ectonucleotidases associated to regulatory T cells are known modulators in the inflammatory environment. Here the authors describe CD8 T cell-derived extracellular vesicles bearing CD73 and suggest they function as an additional intrinsic modulator o
Externí odkaz:
https://doaj.org/article/423c6b103e9d4f51bf3e93a6880c1a59
Autor:
Mélanie Demeules, Allan Scarpitta, Romain Hardet, Henri Gondé, Catalina Abad, Marine Blandin, Stephan Menzel, Yinghui Duan, Björn Rissiek, Tim Magnus, Anna Marei Mann, Friedrich Koch-Nolte, Sahil Adriouch
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Adenosine triphosphate (ATP) represents a danger signal that accumulates in injured tissues, in inflammatory sites, and in the tumor microenvironment. ATP promotes tumor growth but also anti-tumor immune responses notably via the P2X7 receptor. ATP c
Externí odkaz:
https://doaj.org/article/36e4c57c3cd8436f9f1c3d6f35cb19ff
Autor:
Carolina Pinto-Espinoza, Charlotte Guillou, Björn Rissiek, Maximilian Wilmes, Ehsan Javidi, Nicole Schwarz, Marten Junge, Friedrich Haag, Nastassia Liaukouskaya, Nicola Wanner, Annette Nicke, Catelijne Stortelers, Yossan-Var Tan, Sahil Adriouch, Tim Magnus, Friedrich Koch-Nolte
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
The P2X7 ion channel is a key sensor for extracellular ATP and a key trigger of sterile inflammation. Intravenous injection of nanobodies that block P2X7 has shown to be beneficial in mouse models of systemic inflammation. P2X7 has also emerged as an
Externí odkaz:
https://doaj.org/article/386f3b67689741c29d0bc06c088e84e7
Autor:
Laura Schwieren, Märit Jensen, Robert Schulz, Susanne Lezius, Elena Laxy, Magalie Milatz, Götz Thomalla, Rainer Böger, Christian Gerloff, Tim Magnus, Edzard Schwedhelm, Chi-un Choe
Publikováno v:
Life, Vol 13, Iss 7, p 1590 (2023)
Homoarginine is associated with cardio- and cerebrovascular morbidity and mortality. However, the underlying pathomechanisms remain elusive. Here, we evaluated the association of homoarginine with adverse events (i.e., death, stroke, and myocardial i
Externí odkaz:
https://doaj.org/article/998ab16df81141afb4de5c950948418b