Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Tim, Hucho"'
Autor:
Ernesto Lopes Pinheiro-Junior, Ehsan Alirahimi, Steve Peigneur, Jörg Isensee, Susanne Schiffmann, Pelin Erkoc, Robert Fürst, Andreas Vilcinskas, Tobias Sennoner, Ivan Koludarov, Benjamin-Florian Hempel, Jan Tytgat, Tim Hucho, Björn M. von Reumont
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-27 (2024)
Abstract Background The identification of novel toxins from overlooked and taxonomically exceptional species bears potential for various pharmacological applications. The remipede Xibalbanus tulumensis, an underwater cave-dwelling crustacean, is the
Externí odkaz:
https://doaj.org/article/443dff2f8199411aa434218f16c6ab10
Publikováno v:
PAIN Reports, Vol 9, Iss 3, p e1155 (2024)
Abstract. Introduction and Objectives:. Lipedema is a widespread severe chronic disease affecting mostly women. Characterized by painful bilateral fat accumulation in extremities sparing hands and feet, objective measurement-based diagnosis is curren
Externí odkaz:
https://doaj.org/article/31c247b345b24ae490bce9c89f8ac036
Autor:
Leonie Ratz, Chiara Brambillasca, Leandra Bartke, Maxim A. Huetzen, Jonas Goergens, Orsolya Leidecker, Ron D. Jachimowicz, Marieke van de Ven, Natalie Proost, Bjørn Siteur, Renske de Korte-Grimmerink, Peter Bouwman, Emilia M. Pulver, Roebi de Bruijn, Jörg Isensee, Tim Hucho, Gaurav Pandey, Maarten van Lohuizen, Peter Mallmann, Hans Christian Reinhardt, Jos Jonkers, Julian Puppe
Publikováno v:
Breast Cancer Research, Vol 24, Iss 1, Pp 1-19 (2022)
Abstract Background The majority of BRCA1-mutant breast cancers are characterized by a triple-negative phenotype and a basal-like molecular subtype, associated with aggressive clinical behavior. Current treatment options are limited, highlighting the
Externí odkaz:
https://doaj.org/article/9766126bd94646d0abb634dc3e2d1caa
Autor:
Julian Kanne, Michelle Hussong, Jörg Isensee, Álvaro Muñoz-López, Jan Wolffgramm, Felix Heß, Christina Grimm, Sergey Bessonov, Lydia Meder, Jie Wang, H. Christian Reinhardt, Margarete Odenthal, Tim Hucho, Reinhard Büttner, Daniel Summerer, Michal R. Schweiger
Publikováno v:
Cell Death and Disease, Vol 12, Iss 6, Pp 1-15 (2021)
Abstract Non-coding RNA from pericentromeric satellite repeats are involved in stress-dependent splicing processes, maintenance of heterochromatin, and are required to protect genome stability. Here we show that the long non-coding satellite III RNA
Externí odkaz:
https://doaj.org/article/0959e03a10f843b1a00d0335705383db
Autor:
Ines Klein, Jörg Isensee, Martin H. J. Wiesen, Thomas Imhof, Meike K. Wassermann, Carsten Müller, Tim Hucho, Manuel Koch, Helmar C. Lehmann
Publikováno v:
Cells, Vol 12, Iss 9, p 1249 (2023)
Peripheral neuropathy is a common side effect of cancer treatment with paclitaxel. The mechanisms by which paclitaxel is transported into neurons, which are essential for preventing neuropathy, are not well understood. We studied the uptake mechanism
Externí odkaz:
https://doaj.org/article/ea8159b8f82d4bff9777993fe6df54a1
Autor:
Daniel C. Schroeder, Alexandra C. Maul, Esther Mahabir, Isabell Koxholt, Xiaowei Yan, Stephan A. Padosch, Holger Herff, Insa Bultmann-Mellin, Anja Sterner-Kock, Thorsten Annecke, Tim Hucho, Bernd W. Böttiger, Maria Guschlbauer
Publikováno v:
BMC Anesthesiology, Vol 18, Iss 1, Pp 1-10 (2018)
Abstract Background Contribution of the small intestine to systemic inflammation after cardiac arrest (CA) is poorly understood. The objective was to evaluate whether an in vivo rat model of 6 min CA is suitable to initiate intestinal ischaemia-reper
Externí odkaz:
https://doaj.org/article/f1b1d1b8d3c145caaefa26cc0f3825b7
Lipohyperplasia dolorosa (LiDo), also known as lipedema, is a painful subcutaneous adipose tissue disorder. While the characteristic bilateral accumulation of adipocytes in extremities sparing hands and feet is investigated, an objective characteriza
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d31abe40e4a3954cf47f48ce31858da
https://doi.org/10.1101/2023.04.25.23289086
https://doi.org/10.1101/2023.04.25.23289086
Autor:
Hans C. Reinhardt, Tim Hucho, Thorsten Persigehl, Florian Siedek, Rainer W. J. Kaiser, Anna Schmitt, Filippo Beleggia, André Toschka, Leonard A. Lobbes, Jörg Isensee, Joachim D. Steiner, Johanna Erber
The advent of molecularly targeted therapeutic agents has opened a new era in cancer therapy. However, many tumors rely on nondruggable cancer-driving lesions. In addition, long-lasting clinical benefits from single-agent therapies rarely occur, as m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6396e06eeff0ee65f06b6cda1afa5d9
https://doi.org/10.1158/0008-5472.c.6511272.v1
https://doi.org/10.1158/0008-5472.c.6511272.v1
Autor:
Hans C. Reinhardt, Tim Hucho, Thorsten Persigehl, Florian Siedek, Rainer W. J. Kaiser, Anna Schmitt, Filippo Beleggia, André Toschka, Leonard A. Lobbes, Jörg Isensee, Joachim D. Steiner, Johanna Erber
Table S5 contains data of the GSEA analysis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bb3fd557a38b242c30ed65658b3f6db
https://doi.org/10.1158/0008-5472.22422567
https://doi.org/10.1158/0008-5472.22422567
Autor:
Hans C. Reinhardt, Tim Hucho, Thorsten Persigehl, Florian Siedek, Rainer W. J. Kaiser, Anna Schmitt, Filippo Beleggia, André Toschka, Leonard A. Lobbes, Jörg Isensee, Joachim D. Steiner, Johanna Erber
Figure S1 shows single agent dose-response curves of 18 compounds employed in the screen. Figure S2 shows synergy scores of 23 compound combinations. Figure S3 shows the apoptotic effects of single agent inhibitors and their combinations on a panel o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c06490850f1cffd0a2d8d0966d8f1fb0
https://doi.org/10.1158/0008-5472.22422588.v1
https://doi.org/10.1158/0008-5472.22422588.v1