Zobrazeno 1 - 10
of 239
pro vyhledávání: '"Tim, Holland"'
Autor:
Nicolas Carl, Lisa Nguyen, Sarah Haggenmüller, Martin Joachim Hetz, Jana Theres Winterstein, Friedrich Otto Hartung, Britta Gruene, Jakob Nikolas Kather, Tim Holland-Letz, Maurice Stephan Michel, Frederik Wessels, Titus Josef Brinker
Publikováno v:
European Urology Open Science, Vol 70, Iss , Pp 91-98 (2024)
Background and objective: Data on interaction of patients with artificial intelligence (AI) are limited, primarily derived from small-scale studies, cross-sectional surveys, and qualitative reviews. Most patients have not yet encountered AI in their
Externí odkaz:
https://doaj.org/article/96461ba44349479bb2fe3a10c3b55b80
Autor:
Amira-Talaat Moussa, Marco R Cosenza, Timothy Wohlfromm, Katharina Brobeil, Anthony Hill, Annarita Patrizi, Karin Müller-Decker, Tim Holland-Letz, Anna Jauch, Bianca Kraft, Alwin Krämer
Publikováno v:
PLoS Genetics, Vol 20, Iss 10, p e1011460 (2024)
Centrosomes are the major microtubule organizing centers of animal cells. Supernumerary centrosomes are a common feature of human tumors and associated with karyotype abnormalities and aggressive disease, but whether they are cause or consequence of
Externí odkaz:
https://doaj.org/article/887dcd16ee2140f493130d362ed06823
Autor:
Julia Höhn, Eva Krieghoff-Henning, Christoph Wies, Lennard Kiehl, Martin J. Hetz, Tabea-Clara Bucher, Jitendra Jonnagaddala, Kurt Zatloukal, Heimo Müller, Markus Plass, Emilian Jungwirth, Timo Gaiser, Matthias Steeg, Tim Holland-Letz, Hermann Brenner, Michael Hoffmeister, Titus J. Brinker
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-12 (2023)
Abstract Studies have shown that colorectal cancer prognosis can be predicted by deep learning-based analysis of histological tissue sections of the primary tumor. So far, this has been achieved using a binary prediction. Survival curves might contai
Externí odkaz:
https://doaj.org/article/e094c1a7b01c4b7bb8979efab082563b
Autor:
Tim Holland, Jochen Mattner
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-3 (2023)
Externí odkaz:
https://doaj.org/article/0c87f3a898ce48cc82a217a805bc1456
Publikováno v:
Gut Microbes, Vol 15, Iss 1 (2023)
ABSTRACTL-arginine (L-arg) is a versatile amino acid and a central intestinal metabolite in mammalian and microbial organisms. Thus, L-arg participates as precursor of multiple metabolic pathways in the regulation of cell division and growth. It also
Externí odkaz:
https://doaj.org/article/39128c3b4e7548d29cad95805c959f63
Autor:
Heike Peterziel, Nora Jamaladdin, Dina ElHarouni, Xenia F. Gerloff, Sonja Herter, Petra Fiesel, Yannick Berker, Mirjam Blattner-Johnson, Kathrin Schramm, Barbara C. Jones, David Reuss, Laura Turunen, Aileen Friedenauer, Tim Holland-Letz, Martin Sill, Lena Weiser, Christopher Previti, Gnanaprakash Balasubramanian, Nicolas U. Gerber, Johannes Gojo, Caroline Hutter, Ingrid Øra, Olli Lohi, Antonis Kattamis, Bram de Wilde, Frank Westermann, Stephan Tippelt, Norbert Graf, Michaela Nathrath, Monika Sparber-Sauer, Astrid Sehested, Christof M. Kramm, Uta Dirksen, Olli Kallioniemi, Stefan M. Pfister, Cornelis M. van Tilburg, David T. W. Jones, Jani Saarela, Vilja Pietiäinen, Natalie Jäger, Matthias Schlesner, Annette Kopp-Schneider, Sina Oppermann, Till Milde, Olaf Witt, Ina Oehme
Publikováno v:
npj Precision Oncology, Vol 6, Iss 1, Pp 1-17 (2022)
Abstract The international precision oncology program INFORM enrolls relapsed/refractory pediatric cancer patients for comprehensive molecular analysis. We report a two-year pilot study implementing ex vivo drug sensitivity profiling (DSP) using a li
Externí odkaz:
https://doaj.org/article/d21634f309aa434aa0d7808304d8ec37
Autor:
Marcel G.E. Rommel, Lisa Walz, Foteini Fotopoulou, Saskia Kohlscheen, Franziska Schenk, Csaba Miskey, Lacramioara Botezatu, Yvonne Krebs, Iris M. Voelker, Kevin Wittwer, Tim Holland-Letz, Zoltán Ivics, Veronika von Messling, Marieke A.G. Essers, Michael D. Milsom, Christian K. Pfaller, Ute Modlich
Publikováno v:
Cell Reports, Vol 41, Iss 1, Pp 111447- (2022)
Summary: Respiratory tract infections are among the deadliest communicable diseases worldwide. Severe cases of viral lung infections are often associated with a cytokine storm and alternating platelet numbers. We report that hematopoietic stem and pr
Externí odkaz:
https://doaj.org/article/4f2b90b0b8ec49f9816a17097e7b27e9
Autor:
Nikolaus B. Wagner, Benjamin Weide, Mirko Gries, Maike Reith, Kathrin Tarnanidis, Valerie Schuermans, Charlotte Kemper, Coretta Kehrel, Anne Funder, Ramtin Lichtenberger, Antje Sucker, Esther Herpel, Tim Holland-Letz, Dirk Schadendorf, Claus Garbe, Viktor Umansky, Jochen Utikal, Christoffer Gebhardt
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-10 (2019)
Abstract Background Predicting metastasis in melanoma patients is important for disease management and could help to identify those who might benefit from adjuvant treatment. The aim of this study was to investigate whether the tumor microenvironment
Externí odkaz:
https://doaj.org/article/bdaced2bc15445bbb4dd0a04fba39c24
Publikováno v:
Transgenic Research. 32:67-76
In vitro experiments have shown that the E2 protein of human papillomaviruses (HPV) binds to the upstream regulatory region (URR) of the viral genome and modulates transcription. Additionally, it seems to be a necessary component for viral DNA replic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dbf1b262b699d7f6b53bcf72649b0d8b
https://doi.org/10.1007/s11248-023-00336-y
https://doi.org/10.1007/s11248-023-00336-y
Autor:
Tanja B. Jutzi, Eva I. Krieghoff-Henning, Tim Holland-Letz, Jochen Sven Utikal, Axel Hauschild, Dirk Schadendorf, Wiebke Sondermann, Stefan Fröhling, Achim Hekler, Max Schmitt, Roman C. Maron, Titus J. Brinker
Publikováno v:
Frontiers in Medicine, Vol 7 (2020)
Background: Artificial intelligence (AI) has shown promise in numerous experimental studies, particularly in skin cancer diagnostics. Translation of these findings into the clinic is the logical next step. This translation can only be successful if p
Externí odkaz:
https://doaj.org/article/a2ea7c48b75141c293039fa9f43a1545