Neurostructural subgroup in 4291 individuals with schizophrenia identified using the subtype and stage inference algorithm

Autor: Yuchao Jiang, Cheng Luo, Jijun Wang, Lena Palaniyappan, Xiao Chang, Shitong Xiang, Jie Zhang, Mingjun Duan, Huan Huang, Christian Gaser, Kiyotaka Nemoto, Kenichiro Miura, Ryota Hashimoto, Lars T. Westlye, Genevieve Richard, Sara Fernandez-Cabello, Nadine Parker, Ole A. Andreassen, Tilo Kircher, Igor Nenadić, Frederike Stein, Florian Thomas-Odenthal, Lea Teutenberg, Paula Usemann, Udo Dannlowski, Tim Hahn, Dominik Grotegerd, Susanne Meinert, Rebekka Lencer, Yingying Tang, Tianhong Zhang, Chunbo Li, Weihua Yue, Yuyanan Zhang, Xin Yu, Enpeng Zhou, Ching-Po Lin, Shih-Jen Tsai, Amanda L. Rodrigue, David Glahn, Godfrey Pearlson, John Blangero, Andriana Karuk, Edith Pomarol-Clotet, Raymond Salvador, Paola Fuentes-Claramonte, María Ángeles Garcia-León, Gianfranco Spalletta, Fabrizio Piras, Daniela Vecchio, Nerisa Banaj, Jingliang Cheng, Zhening Liu, Jie Yang, Ali Saffet Gonul, Ozgul Uslu, Birce Begum Burhanoglu, Aslihan Uyar Demir, Kelly Rootes-Murdy, Vince D. Calhoun, Kang Sim, Melissa Green, Yann Quidé, Young Chul Chung, Woo-Sung Kim, Scott R. Sponheim, Caroline Demro, Ian S. Ramsay, Felice Iasevoli, Andrea de Bartolomeis, Annarita Barone, Mariateresa Ciccarelli, Arturo Brunetti, Sirio Cocozza, Giuseppe Pontillo, Mario Tranfa, Min Tae M. Park, Matthias Kirschner, Foivos Georgiadis, Stefan Kaiser, Tamsyn E. Van Rheenen, Susan L. Rossell, Matthew Hughes, William Woods, Sean P. Carruthers, Philip Sumner, Elysha Ringin, Filip Spaniel, Antonin Skoch, David Tomecek, Philipp Homan, Stephanie Homan, Wolfgang Omlor, Giacomo Cecere, Dana D. Nguyen, Adrian Preda, Sophia I. Thomopoulos, Neda Jahanshad, Long-Biao Cui, Dezhong Yao, Paul M. Thompson, Jessica A. Turner, Theo G. M. van Erp, Wei Cheng, ENIGMA Schizophrenia Consortium, Jianfeng Feng, ZIB Consortium

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)

Abstract Machine learning can be used to define subtypes of psychiatric conditions based on shared biological foundations of mental disorders. Here we analyzed cross-sectional brain images from 4,222 individuals with schizophrenia and 7038 healthy su

Externí odkaz: https://doaj.org/article/76bdd81832814fb8a0f1d01e09c35de4

Factor analysis of lifetime psychopathology and its brain morphometric and genetic correlates in a transdiagnostic sample

Autor: Axel Krug, Frederike Stein, Friederike S. David, Simon Schmitt, Katharina Brosch, Julia-Katharina Pfarr, Kai G. Ringwald, Tina Meller, Florian Thomas-Odenthal, Susanne Meinert, Katharina Thiel, Alexandra Winter, Lena Waltemate, Hannah Lemke, Dominik Grotegerd, Nils Opel, Jonathan Repple, Tim Hahn, Fabian Streit, Stephanie H. Witt, Marcella Rietschel, Till F. M. Andlauer, Markus M. Nöthen, Alexandra Philipsen, Igor Nenadić, Udo Dannlowski, Tilo Kircher, Andreas J. Forstner

Publikováno v: Translational Psychiatry, Vol 14, Iss 1, Pp 1-10 (2024)

Abstract There is a lack of knowledge regarding the relationship between proneness to dimensional psychopathological syndromes and the underlying pathogenesis across major psychiatric disorders, i.e., Major Depressive Disorder (MDD), Bipolar Disorder

Externí odkaz: https://doaj.org/article/d412174d62634d728bbe586b111c1f70

Formalizing psychological interventions through network control theory

Autor: Julia Elina Stocker, Georgia Koppe, Hanna Reich, Saeideh Heshmati, Sarah Kittel-Schneider, Stefan G. Hofmann, Tim Hahn, Han L. J. van der Maas, Lourens Waldorp, Hamidreza Jamalabadi

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)

Abstract Despite the growing deployment of network representation to comprehend psychological phenomena, the question of whether and how networks can effectively describe the effects of psychological interventions remains elusive. Network control the

Externí odkaz: https://doaj.org/article/2890053f1c6340fc9e6a1620db37af04

Data-driven multivariate identification of gyrification patterns in a transdiagnostic patient cohort: A cluster analysis approach

Autor: Julia-Katharina Pfarr, Tina Meller, Katharina Brosch, Frederike Stein, Florian Thomas-Odenthal, Ulrika Evermann, Adrian Wroblewski, Kai G. Ringwald, Tim Hahn, Susanne Meinert, Alexandra Winter, Katharina Thiel, Kira Flinkenflügel, Andreas Jansen, Axel Krug, Udo Dannlowski, Tilo Kircher, Christian Gaser, Igor Nenadić

Publikováno v: NeuroImage, Vol 281, Iss , Pp 120349- (2023)

Background: Multivariate data-driven statistical approaches offer the opportunity to study multi-dimensional interdependences between a large set of biological parameters, such as high-dimensional brain imaging data. For gyrification, a putative mark

Externí odkaz: https://doaj.org/article/1f7776744dd8440caf34f9f9a6c3c90d

Association of polysialic acid serum levels with schizophrenia spectrum and bipolar disorder-related structural brain changes and hospitalization

Autor: Louisa Müller-Miny, Katharina Thiel, Susanne Meinert, Tim Hahn, Tilo Kircher, Igor Nenadić, Axel Krug, Felix Hufschmidt, Huan Liao, Harald Neumann, Udo Dannlowski, Jan D. Lünemann

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)

Abstract Expression of polysialic acid (polySia) in the adult brain is enriched in areas of continuous neurogenesis and plasticity such as the hippocampus. Genome-wide association studies identified variants of glycosylation enzyme-encoding genes, re

Externí odkaz: https://doaj.org/article/a7bdb3a172d847db848f1265b0e7f923