Zobrazeno 1 - 10
of 118
pro vyhledávání: '"Tilo Kunath"'
Autor:
Gurvir S. Virdi, Minee L. Choi, James R. Evans, Zhi Yao, Dilan Athauda, Stephanie Strohbuecker, Raja S. Nirujogi, Anna I. Wernick, Noelia Pelegrina-Hidalgo, Craig Leighton, Rebecca S. Saleeb, Olga Kopach, Haya Alrashidi, Daniela Melandri, Jimena Perez-Lloret, Plamena R. Angelova, Sergiy Sylantyev, Simon Eaton, Simon Heales, Dmitri A. Rusakov, Dario R. Alessi, Tilo Kunath, Mathew H. Horrocks, Andrey Y. Abramov, Rickie Patani, Sonia Gandhi
Publikováno v:
npj Parkinson's Disease, Vol 8, Iss 1, Pp 1-22 (2022)
Abstract Mutations in the SNCA gene cause autosomal dominant Parkinson’s disease (PD), with loss of dopaminergic neurons in the substantia nigra, and aggregation of α-synuclein. The sequence of molecular events that proceed from an SNCA mutation d
Externí odkaz:
https://doaj.org/article/fc1ba7fa6d614cbe962ce2b5a05c4fa6
Autor:
Qianqian Zhuang, Fengfeng Guo, Lei Fu, Yufei Dong, Shaofang Xie, Xue Ding, Shuangyi Hu, Xuanhao D. Zhou, Yangwei Jiang, Hui Zhou, Yue Qiu, Zhaoying Lei, Mengyao Li, Huajian Cai, Mingjie Fan, Lingjie Sang, Yong Fu, Dong Zhang, Aifu Lin, Xu Li, Tilo Kunath, Ruhong Zhou, Ping Liang, Zhong Liu, Qingfeng Yan
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 14 (2023)
Hypertrophic cardiomyopathy (HCM) is the most prominent cause of sudden cardiac death in young people. Due to heterogeneity in clinical manifestations, conventional HCM drugs have limitations for mitochondrial hypertrophic cardiomyopathy. Discovering
Externí odkaz:
https://doaj.org/article/c9d19fddd89f4d1ba21d12badf5c0d14
Autor:
Victoria Morley, Karamjit Singh Dolt, Carlos J. Alcaide-Corral, Tashfeen Walton, Christophe Lucatelli, Tomoji Mashimo, Adriana A. S. Tavares, Tilo Kunath
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
Parkinson’s disease (PD) is a neurodegenerative condition with several major hallmarks, including loss of substantia nigra neurons, reduction in striatal dopaminergic function, and formation of α-synuclein-rich Lewy bodies. Mutations in SNCA, enco
Externí odkaz:
https://doaj.org/article/ac877aa1883140ea863b35dd5f13ac63
Publikováno v:
STAR Protocols, Vol 3, Iss 2, Pp 101247- (2022)
Summary: The neuroprotective E3-ubiquitin ligase CHIP is linked to healthy aging. Here, we present a protocol using a patient-derived iPSC line with a triplication of the α-synuclein gene to produce gene-edited cells isogenic for CHIP. We describe i
Externí odkaz:
https://doaj.org/article/9a6047e2764240678c08947604e8d494
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
α-Synuclein (αSyn) is a small, disordered protein that becomes aggregated in Lewy body diseases, such as Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). Human induced pluripotent stem cells (hiPSCs) potentially provide a tractable d
Externí odkaz:
https://doaj.org/article/9b474fdbe7dc48e388a0d516b9449960
Autor:
Eleanor Sinclair, Drupad K. Trivedi, Depanjan Sarkar, Caitlin Walton-Doyle, Joy Milne, Tilo Kunath, Anouk M. Rijs, Rob M. A. de Bie, Royston Goodacre, Monty Silverdale, Perdita Barran
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Studies of metabolites in neurodegeneration have not yet used sebum as a source fluid. Here the authors demonstrate the potential of metabolomics of sebum samples from individuals with Parkinson’s disease and controls.
Externí odkaz:
https://doaj.org/article/9e01bc89a95e413fbdff0e9ee7e5a51b
Autor:
Eleanor Sinclair, Caitlin Walton-Doyle, Depanjan Sarkar, Katherine A. Hollywood, Joy Milne, Sze Hway Lim, Tilo Kunath, Anouk M. Rijs, Rob M. A. de Bie, Monty Silverdale, Drupad K. Trivedi, Perdita Barran
Publikováno v:
ACS Central Science, Vol 7, Iss 2, Pp 300-306 (2021)
Externí odkaz:
https://doaj.org/article/61914eed69b4433196490a6d54ff8a52
Autor:
Catarina Dias, Erisa Nita, Jakub Faktor, Ailish C. Tynan, Lenka Hernychova, Borivoj Vojtesek, Jesper Nylandsted, Ted R. Hupp, Tilo Kunath, Kathryn L. Ball
Publikováno v:
iScience, Vol 25, Iss 3, Pp 103921- (2022)
Externí odkaz:
https://doaj.org/article/184f2fb85b014d7dbde811a7e9b3a77b
Autor:
Catarina Dias, Erisa Nita, Jakub Faktor, Ailish C. Tynan, Lenka Hernychova, Borivoj Vojtesek, Jesper Nylandsted, Ted R. Hupp, Tilo Kunath, Kathryn L. Ball
Publikováno v:
iScience, Vol 24, Iss 8, Pp 102878- (2021)
Summary: CHIP is an E3-ubiquitin ligase that contributes to healthy aging and has been characterized as neuroprotective. To elucidate dominant CHIP-dependent changes in protein steady-state levels in a patient-derived human neuronal model, CHIP funct
Externí odkaz:
https://doaj.org/article/01017be915b44be0856d83d5615cd1e0
Autor:
Yu Wang, Michael H. Tatham, Wolfgang Schmidt-Heck, Carolyn Swann, Karamjit Singh-Dolt, Jose Meseguer-Ripolles, Baltasar Lucendo-Villarin, Tilo Kunath, Timothy R. Rudd, Andrew J.H. Smith, Jan G. Hengstler, Patricio Godoy, Ronald T. Hay, David C. Hay
Publikováno v:
iScience, Vol 16, Iss , Pp 206-217 (2019)
Summary: During mammalian development, liver differentiation is driven by signals that converge on multiple transcription factor networks. The hepatocyte nuclear factor signaling network is known to be essential for hepatocyte specification and maint
Externí odkaz:
https://doaj.org/article/4a91a3c282f3471bad0373765ad436f8