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Akademický článek

Quantitatively measuring the cytotoxicity of viscous hydrogels with direct cell sampling in a micro scale format 'MicroDrop' and its comparison to CCK8

Autor: Anna Marie Margot, Andreas Engels, Michael Sittinger, Tilo Dehne, Shabnam Hemmati-Sadeghi

Publikováno v: Journal of Materials Science: Materials in Medicine, Vol 35, Iss 1, Pp 1-15 (2024)

Abstract Tissue engineering holds promise for developing therapeutic applications using viscous materials e.g. hydrogels. However, assessing the cytotoxicity of such materials with conventional assays can be challenging due to non-specific interactio

Externí odkaz: https://doaj.org/article/36d45c40499c43a3b132f2b9123f9dc1

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Akademický článek

3D Inkjet Printing of Biomaterials with Solvent‐Free, Thiol‐Yne‐Based Photocurable Inks

Autor: Michael Kainz, Stephan Haudum, Elena Guillén, Oliver Brüggemann, Rita Höller, Heike Frommwald, Tilo Dehne, Michael Sittinger, Disha Tupe, Zoltan Major, Gerald Stubauer, Thomas Griesser, Ian Teasdale

Publikováno v: Macromolecular Materials and Engineering, Vol 309, Iss 5, Pp n/a-n/a (2024)

Abstract 3D inkjet printing is a fast, reliable, and non‐contact bottom–up approach to printing small and large models and is one of the fastest additive manufacturing technologies available. These attributes position inkjet printing as a promisi

Externí odkaz: https://doaj.org/article/7afb5196c92e4fc4b8f2391fbb22e3dd

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3D Printing of Bone Substitutes Based on Vat Photopolymerization Processes: A Systematic Review

Autor: Simon Enbergs, Jacob Spinnen, Tilo Dehne, Michael Sittinger

Publikováno v: Journal of Tissue Engineering and Regenerative Medicine. 2023:1-18

Treatment options for critically sized bone defects are currently limited to metal osteosynthesis, autologous bone grafting, or calcium-based implants to bridge the gap. Additive manufacturing techniques pose a possible alternative. The light-basedth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fac098338adeef83e54d6a8a3a5f530d
https://doi.org/10.1155/2023/3901448

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Amino acid-based polyphosphorodiamidates with hydrolytically labile bonds for degradation-tuned photopolymers

Autor: Stephan Haudum, Stefan Lenhart, Stefanie M. Müller, Disha Tupe, Christoph Naderer, Tilo Dehne, Michael Sittinger, Zoltan Major, Thomas Griesser, Oliver Brüggemann, Jaroslaw Jacak, Ian Teasdale

Photochemical additive manufacturing technologies can produce complex geometries in short production times and thus have considerable potential as a tool to fabricate medical devices such as individualised patient-specific implants, prosthetics and t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bba3cbd4c3d747d56ee08d6aacdac0e
https://doi.org/10.26434/chemrxiv-2023-fq1mv

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Sleeping beauty transposon system for GDNF overexpression of entrapped stem cells in fibrin hydrogel in a rat model of Parkinson’s disease

Autor: Laura Stahn, Justyna Rasińska, Tilo Dehne, Stefanie Schreyer, Aileen Hakus, Manfred Gossen, Barbara Steiner, Shabnam Hemmati-Sadeghi

Publikováno v: Stahn, L.; Rasińska, J.; Dehne, T.; Schreyer, S.; Hakus, A.; Gossen, M.; Steiner, B.; Hemmati-Sadeghi, S.: Sleeping beauty transposon system for GDNF overexpression of entrapped stem cells in fibrin hydrogel in a rat model of Parkinson’s disease. In: Drug Delivery and Translational Research. Vol. 13 (2023) 1745-1765. (DOI: /10.1007/s13346-023-01289-9)

There is currently no causal treatment available for Parkinson’s disease (PD). However, the use of glial cell line–derived neurotrophic factor (GDNF) to provide regenerative effects for neurons is promising. Such approaches require translational

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8db912b583701e252dda57a53fa36115
https://publications.hereon.de/id/51317

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Blends of gelatin and hyaluronic acid stratified by stereolithographic bioprinting approximate cartilaginous matrix gradients

Autor: Lennard K. Shopperly, Jacob Spinnen, Jan‐Philipp Krüger, Michaela Endres, Michael Sittinger, Tobias Lam, Lutz Kloke, Tilo Dehne

Publikováno v: Journal of biomedical materials research. Part B, Applied biomaterialsREFERENCES. 110(10)

Stereolithographic bioprinting holds great promise in the quest for creating artificial, biomimetic cartilage-like tissue. To introduce a more biomimetic approach, we examined blending and stratifying methacrylated hyaluronic acid (HAMA) and methacry

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94a2a0d1a5fdba88ec0aace56b9f2ff0
https://pubmed.ncbi.nlm.nih.gov/35532378

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CCL25‐Supplemented Hyaluronic Acid Attenuates Cartilage Degeneration in a Guinea Pig Model of Knee Osteoarthritis

Autor: Jochen Ringe, Michael Sittinger, Shabnam Hemmati-Sadeghi, Andreas Engels, Kristin Fröhlich, Tilo Dehne, Katja Reiter

Publikováno v: Journal of Orthopaedic Research. 37:1723-1729

There is evidence that the application of mesenchymal stromal cells (MSCs) counteracts osteoarthritis (OA) progression. However, the prospect of extracting and expanding these cells might be limited. The aim of this study was to investigate whether h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c445fce42cea66516997391feb58e3a
https://doi.org/10.1002/jor.24312

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Photopolymerizable gelatin and hyaluronic acid for stereolithographic 3D bioprinting of tissue‐engineered cartilage

Autor: Tilo Dehne, Sylvia Hondke, Roland Lauster, Michaela Endres, Lutz Kloke, Jan Philipp Krüger, Tobias Lam, Alexander Thomas, Michael Sittinger

Publikováno v: Journal of Biomedical Materials Research. Part B, Applied Biomaterials

To create artificial cartilage in vitro, mimicking the function of native extracellular matrix (ECM) and morphological cartilage‐like shape is essential. The interplay of cell patterning and matrix concentration has high impact on the phenotype and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27119e859e7c9d6a1ff4e73ba8ef83e1
https://doi.org/10.1002/jbm.b.34354

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Osteochondral Live Slices as Physiological in-vitro Model of the Human Joint for High-throughput Applications

Autor: Jacob Spinnen, Carsten Rendenbach, Anja Kühl, Ufuk Sentürk, Daniel Kendoff, Henrik Mei, Michael Sittinger, Tilo Dehne

Background: Current advances in musculoskeletal research yielded numerous new insights and therapy options for diseases of the joints but preclinical in-vitro testing is currently limited to self-manufactured 2D and 3D cell cultures only remotely mim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e085460e808d8d052d37dea5774da5a5
https://doi.org/10.21203/rs.3.rs-68789/v1

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Biomimetic sulfated polyethylene glycol hydrogel inhibits proteoglycan loss and tumor necrosis factor-α-induced expression pattern in an osteoarthritisin vitromodel

Autor: Jochen Ringe, Shabnam Hemmati-Sadeghi, Tilo Dehne, Pradip Dey, Rainer Haag, Michael Sittinger

Publikováno v: Journal of Biomedical Materials Research Part B: Applied Biomaterials. 107:490-500

This study aimed to evaluate the potential of an anti-inflammatory polyethylene glycol (PEG) hydrogel for osteoarthritis (OA) management in an OA in vitro model. Freshly isolated porcine chondrocytes were maintained in high-density cultures to form c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5fc2ffc692a65986aa77b0a52b172d62
https://doi.org/10.1002/jbm.b.34139

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