Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Tilman Sanchez-Elsner"'
Autor:
Chuan Wang, Kaïdre Bendjama, Stephen Schoenberger, Oliver Wood, Gareth Thomas, Pandurangan Vijayanand, Tilman Sanchez-Elsner, Nathalie Silvestre, Natalia Savelyeva, Christian Ottensmeier, Katy McCann, Adrian von Witzleben, Jaya Thomas, Divya Singh, Konstantinos Boukas, Finn Cilius Nielsen, Jason Greenbaum, Bjoern Peters
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 3 (2022)
Background Cancer is characterized by an accumulation of somatic mutations, of which a significant subset can generate cancer-specific neoepitopes that are recognized by autologous T cells. Such neoepitopes are emerging as important targets for cance
Externí odkaz:
https://doaj.org/article/f2e7b76ffbf04704a85332017c66893b
Autor:
Mohammed A. Kyyaly, Tilman Sanchez‐Elsner, Peijun He, Collin L. Sones, S. Hasan Arshad, Ramesh J. Kurukulaaratchy
Publikováno v:
Clinical and Translational Allergy, Vol 11, Iss 4, Pp n/a-n/a (2021)
Abstract Background Identifying patients at risk of severe asthma is vitally important given the disproportionate burden of disease imposed by that state. However, biomarkers to support such needs remain elusive. Methods In this letter, we assessed w
Externí odkaz:
https://doaj.org/article/6abaf028ae6746e5915372ccf070cdaa
Autor:
Eva M Garrido-Martin, Toby W P Mellows, James Clarke, Anusha-Preethi Ganesan, Oliver Wood, Angelica Cazaly, Gregory Seumois, Serena J Chee, Aiman Alzetani, Emma V King, Gareth Thomas, Peter S Friedmann, Pandurangan Vijayanand, Tilman Sanchez-Elsner
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background The role of tumor-associated macrophages (TAMs) in determining the outcome between the antitumor effects of the adaptive immune system and the tumor’s anti-immunity stratagems, is controversial. Macrophages modulate their activities and
Externí odkaz:
https://doaj.org/article/78a908b9b0784fee9b20195130c12164
Publikováno v:
PLoS ONE, Vol 13, Iss 11, p e0207248 (2018)
BACKGROUND:The objective of this study was to investigate the expression and localisation of thymosin β4 (Tβ4) in the developing human heart. Tβ4 is a cardioprotective protein which may have therapeutic potential. While Tβ4 is an endogenously pro
Externí odkaz:
https://doaj.org/article/e84083b56ae745beb59c6880ed9b6771
Autor:
Patience T Brace, Liku B Tezera, Magdalena K Bielecka, Toby Mellows, Diana Garay, Shuye Tian, Lucinda Rand, Justin Green, Sanjay Jogai, Andrew J Steele, Timothy M Millar, Tilman Sanchez-Elsner, Jon S Friedland, Christopher G Proud, Paul T Elkington
Publikováno v:
PLoS Pathogens, Vol 13, Iss 6, p e1006367 (2017)
Tuberculosis remains a global pandemic and drives lung matrix destruction to transmit. Whilst pathways driving inflammatory responses in macrophages have been relatively well described, negative regulatory pathways are less well defined. We hypothesi
Externí odkaz:
https://doaj.org/article/ebe696729b734247b66859eda36251bf
Autor:
Ana S. Francisco-Garcia, Eva M. Garrido-Martín, Hitasha Rupani, Laurie C. K. Lau, Rocio T. Martinez-Nunez, Peter H. Howarth, Tilman Sanchez-Elsner
Publikováno v:
Non-Coding RNA, Vol 5, Iss 4, p 51 (2019)
MicroRNAs are known to regulate important pathways in asthma pathology including the IL-6 and IFN pathways. MicroRNAs have been found not only within cells but also within extracellular vesicles such as exosomes. In this study, we particularly focuse
Externí odkaz:
https://doaj.org/article/6e44121955f34799bb921e957446d686
Autor:
Rocio T Martinez-Nunez, Victor P Bondanese, Fethi Louafi, Ana S Francisco-Garcia, Hitasha Rupani, Nicole Bedke, Stephen Holgate, Peter H Howarth, Donna E Davies, Tilman Sanchez-Elsner
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e111659 (2014)
MicroRNAs are short non-coding single stranded RNAs that regulate gene expression. While much is known about the effects of individual microRNAs, there is now growing evidence that they can work in co-operative networks. MicroRNAs are known to be dys
Externí odkaz:
https://doaj.org/article/d6a89c9e62144854aee37d6b2d081383
Autor:
Raffaella Petruzzelli, David R Christensen, Kate L Parry, Tilman Sanchez-Elsner, Franchesca D Houghton
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e108309 (2014)
Low O2 tension is beneficial for human embryonic stem cell (hESC) maintenance but the mechanism of regulation is unknown. HIF-2α was found to bind directly to predicted hypoxic response elements (HREs) in the proximal promoter of OCT4, NANOG and SOX
Externí odkaz:
https://doaj.org/article/8aac01414f9c45d3a2fb3f181c899cf4
Autor:
Kelvin S C Cheung, Nunzia Sposito, Patrick S Stumpf, David I Wilson, Tilman Sanchez-Elsner, Richard O C Oreffo
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e98063 (2014)
MicroRNAs (miRs) play a pivotal role in a variety of biological processes including stem cell differentiation and function. Human foetal femur derived skeletal stem cells (SSCs) display enhanced proliferation and multipotential capacity indicating ex
Externí odkaz:
https://doaj.org/article/1eec308b12e342ac86b1370f59d72138
Autor:
Catherine E Forristal, David R Christensen, Fay E Chinnery, Raffaella Petruzzelli, Kate L Parry, Tilman Sanchez-Elsner, Franchesca D Houghton
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e62507 (2013)
Energy metabolism is intrinsic to cell viability but surprisingly has been little studied in human embryonic stem cells (hESCs). The current study aims to investigate the effect of environmental O2 tension on carbohydrate utilisation of hESCs. Highly
Externí odkaz:
https://doaj.org/article/ba1b8fe218e34a1dbb4e0fee01a9cbbf