Výsledky vyhledávání - "Tilman Dumrese"

Expansion of protective CD8+ T-cell responses driven by recombinant cytomegaloviruses

Autor: Annette Oxenius, Urs Karrer, Paul Klenerman, Ulrich H. Koszinowski, Markus Wagner, Hartmut Hengel, Tilman Dumrese, Stefan Freigang, Sophie Sierro, Rodney E. Phillips

CD8+T cells are critical for the control of many persistent viral infections, such as human immunodeficiency virus, hepatitis C virus, Epstein-Barr virus, and cytomegalovirus (CMV). In most infections, large CD8+-T-cell populations are induced early

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77b35a48c13e8104d5fa232f63b5ea06
https://doi.org/10.1128/jvi.78.5.2255-2264.2004

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Virus-Induced Activation of Self-Specific TCRαβ CD8αα Intraepithelial Lymphocytes Does Not Abolish Their Self-Tolerance in the Intestine

Autor: Leslie Saurer, Inge Seibold, Claudio Vallan, Christoph Mueller, Silvia Rihs, Tilman Dumrese

Publikováno v: Scopus-Elsevier

TCRαβ CD8αα intestinal intraepithelial lymphocytes (IEL) represent an enigmatic subset of T cells, particularly, in regard to their potential functions and the apparent persistence of cells expressing self-specific TCR. We have used mice that are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fed75211072df1c0b5053e2069965089
https://doi.org/10.4049/jimmunol.172.7.4176

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Lack of Effector Cell Function and Altered Tetramer Binding of Tumor-Infiltrating Lymphocytes

Autor: Kathrin Brommer, Ulrike Blohm, Felicia M. Rosenthal, Evelyn Roth, Hanspeter Pircher, Tilman Dumrese

Publikováno v: The Journal of Immunology. 169:5522-5530

Tumor-specific CD8 T cell responses to MCA102 fibrosarcoma cells expressing the cytotoxic T cell epitope gp33 from lymphocytic choriomeningitis virus were studied. MCA102gp33 tumors grew progressively in C57BL/6 mice, despite induction of peripheral

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b61661aebbc108b133ce506c3ce53018
https://doi.org/10.4049/jimmunol.169.10.5522

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A Naturally Processed Rat Major Histocompatibility Complex Class I-associated Viral Peptide as Target Structure of Borna Disease Virus-specific CD8+ T Cells

Autor: Oliver Planz, Silke Hülpüsch, Markus Schirle, Tilman Dumrese, Stefan Stevanovic, Lothar Stitz

Publikováno v: Journal of Biological Chemistry. 276:13689-13694

The first naturally processed peptide synthesized by a virus and recognized by classical CD8(+) T cells in association with the RT1.A(l) major histocompatibility complex class I molecule of the Lewis rat is reported. Borna disease virus-specific CD8(

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c3a07cdb4ce06419a01a5e35ac52898
https://doi.org/10.1074/jbc.m009889200

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Rapid Peptide Turnover and Inefficient Presentation of Exogenous Antigen Critically Limit the Activation of Self-Reactive CTL by Dendritic Cells

Autor: Cornelis J. M. Melief, Marcus Pericin, Adrian F. Ochsenbein, Hans Hengartner, Kathy D. McCoy, Rolf M. Zinkernagel, René E. M. Toes, Tilman Dumrese, Bernhard Odermatt, Burkhard Ludewig

Publikováno v: The Journal of Immunology. 166:3678-3687

This study evaluated to what extent presentation of exogenously acquired self-Ags via MHC class I molecules on DC might contribute to the activation of self-reactive CTL and subsequent development of autoimmune disease. We show here by using the rat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9ac681e1c3de5387bd4cc353759c481
https://doi.org/10.4049/jimmunol.166.6.3678

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Role of anchor residues in peptide binding to three HLA-A26 molecules

Autor: Yoshihide Ishikawa, Tetsuo Nagatani, Tilman Dumrese, Masafumi Takiguchi, N. Yamada, Hans-Georg Rammensee, Takeo Juji, Kiyoshi Miwa, Katsushi Tokunaga

Publikováno v: Tissue Antigens. 54:325-332

To investigate the role of anchor residues in HLA-A26 binding peptides, we analyzed the binding of various peptides to three HLA-A26 molecules using the HLA class I stabilization assay. Of twenty nonamer peptides carrying anchors at P2 and P9, 3, 6 a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a10ea1b6a7bfea61d1232fe2ae857976
https://doi.org/10.1034/j.1399-0039.1999.540401.x

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A protective cytotoxic T cell response to a subdominant epitope is influenced by the stability of the MHC class I/peptide complex and the overall spectrum of viral peptides generated within infected cells

Autor: Rolf M. Zinkernagel, Hans Hengartner, Tilman Dumrese, Awen Gallimore, Joachim Hombach, Hans-Georg Rammensee

Publikováno v: European Journal of Immunology. 28:3301-3311

This study identifies instability of MHC class I/peptide complexes and intermolecular competition for MHC class I presentation as factors responsible for the subdominance of cytotoxic T lymphocyte (CTL) epitopes. This evidence is based on the charact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ddebab4c93c59171832c52e6bd71239
https://doi.org/10.1002/(sici)1521-4141(199810)28:10<3301::aid-immu3301>3.0.co

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Substrate Specificity of Cathepsins D and E Determined by N-Terminal and C-terminal Sequencing of Peptide Pools

Autor: Hans-Georg Rammensee, Danièle Arnold, Tilman Dumrese, Hansjörg Schild, Wieland Keilholz, Stefan Stevanovic

Publikováno v: European Journal of Biochemistry. 249:171-179

Degradation of protein antigens by cellular proteases is a crucial step in the initiation of a T-cell-mediated immune response. But still little is known about the enzymes responsible for the processing of antigens, including their specificity. In th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecc1486bf023723fc69e1c4ffbc6a1e7
https://doi.org/10.1111/j.1432-1033.1997.t01-1-00171.x

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Perforin and Fas act together in the induction of apoptosis, and both are critical in the clearance of lymphocytic choriomeningitis virus infection

Autor: Reina Brehm, Thomas Stehle, Miriam Rode, Vera Sobek, Praxedis Martin, Reinhard Wallich, Arno Müllbacher, Sandra Balkow, Astrid Kersten, Tilman Dumrese, Markus M. Simon

Publikováno v: Journal of virology. 78(22)

In this report we questioned the current view that the two principal cytotoxic pathways, the exocytosis and the Fas ligand (FasL)/Fas-mediated pathway, have largely nonoverlapping biological roles. For this purpose we have analyzed the response of mi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15ee3bc6554e00d0d25c12b796e1ed6e
https://pubmed.ncbi.nlm.nih.gov/15507626

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