SORLA-Dependent and -Independent Functions for PACS1 in Control of Amyloidogenic Processes

Autor: Anne-Sophie Carlo, Tilman Burgert, Thomas E. Willnow, Anders Nykjaer, Annette Füchtbauer, Safak Caglayan, Ernst-Martin Füchtbauer, Vanessa Schmidt, Fuyu Lin

Publikováno v: Burgert, T, Schmidt, V, Caglayan, S, Lin, F, Füchtbauer, A, Füchtbauer, E-M, Nykjaer, A, Carlo, A-S & Willnow, T E 2013, ' SORLA-Dependent and-Independent Functions for PACS1 in Control of Amyloidogenic Processes ', Molecular and Cellular Biology, vol. 33, no. 21, pp. 4308-4320 . https://doi.org/10.1128/MCB.00628-13

Sorting-related receptor with A-type repeats (SORLA) is a sorting receptor for the amyloid precursor protein (APP) that prevents breakdown of APP into Aβ peptides, a hallmark of Alzheimer's disease (AD). Several cytosolic adaptors have been shown to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8d87f68cc420e97750da48e2d1161ab
https://doi.org/10.1128/mcb.00628-13

The pro-neurotrophin receptor sortilin is a major neuronal apolipoprotein E receptor for catabolism of amyloid-β peptide in the brain

Autor: Michael Rohe, Tilman Burgert, Anne Sophie Carlo, Claus Munck Petersen, Thomas E. Willnow, Camilla Gustafsen, Anders Nykjaer, Joachim Herz, Guido Mastrobuoni, Morten Nielsen, Stefan Kempa, Joerg Heeren, Daniela Hartl

Publikováno v: Carlo, A-S, Gustafsen, C, Mastrobuoni, G, Nielsen, M S, Burgert, T, Hartl, D, Rohe, M, Nykjaer, A, Herz, J, Heeren, J, Kempa, S, Petersen, C M & Willnow, T E 2013, ' The Pro-Neurotrophin Receptor Sortilin Is a Major Neuronal Apolipoprotein E Receptor for Catabolism of Amyloid-β Peptide in the Brain ', Journal of Neuroscience, vol. 33, no. 1, pp. 358-70 . https://doi.org/10.1523/JNEUROSCI.2425-12.2013

In the brain, apolipoprotein E (APOE) delivers cholesterol-rich lipoproteins to neurons to support synaptogenesis and maintenance of synaptic connections. Three APOE alleles exist in the human population with ε4 being an Alzheimer disease (AD) risk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8252575beac345c6a25c2e841847b1b8
https://pubmed.ncbi.nlm.nih.gov/24121631

P3‐198: Relevance of the interaction between SORLA and cytosolic adaptor proteins for amyloidogenic processing

Autor: Tilman Burgert, Safak Caglayan, Thomas E. Willnow, Vanessa Schmidt

Publikováno v: Alzheimer's & Dementia. 7

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a7452f007757fc24c43edfdf1a2244ad
https://doi.org/10.1016/j.jalz.2011.05.1639