Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Tilman Aden"'
Autor:
Katharina Rox, Tim Becker, Andrea Schiefer, Miriam Grosse, Alexandra Ehrens, Rolf Jansen, Tilman Aden, Stefan Kehraus, Gabriele M. König, Anna K. Krome, Marc P. Hübner, Karl G. Wagner, Marc Stadler, Kenneth Pfarr, Achim Hoerauf
Publikováno v:
Pharmaceutics, Vol 15, Iss 1, p 131 (2022)
Methicillin-resistant Staphylococcus aureus (MRSA) is a World Health Organization’s high priority pathogen organism, with an estimated > 100,000 deaths worldwide in 2019. Thus, there is an unmet medical need for novel and resistance-breaking anti-i
Externí odkaz:
https://doaj.org/article/edb4852a2b3245799a4221b686948f81
Autor:
Tim Becker, Anna K. Krome, Sahel Vahdati, Andrea Schiefer, Kenneth Pfarr, Alexandra Ehrens, Tilman Aden, Miriam Grosse, Rolf Jansen, Silke Alt, Thomas Hesterkamp, Marc Stadler, Marc P. Hübner, Stefan Kehraus, Gabriele M. König, Achim Hoerauf, Karl G. Wagner
Publikováno v:
Pharmaceutics, Vol 14, Iss 8, p 1657 (2022)
In vivo studies in mice provide a valuable model to test novel active pharmaceutical ingredients due to their low material need and the fact that mice are frequently used as a species for early efficacy models. However, preclinical in vitro evaluatio
Externí odkaz:
https://doaj.org/article/d722c35fa6af4f79a653c16ff534728b
Autor:
Jan Balansky, Kenneth Pfarr, Christiane Szekat, Stefan Kehraus, Tilman Aden, Miriam Grosse, Rolf Jansen, Thomas Hesterkamp, Andrea Schiefer, Gabriele M. König, Marc Stadler, Achim Hoerauf, Gabriele Bierbaum
Publikováno v:
Antibiotics, Vol 11, Iss 7, p 920 (2022)
Corallopyronin A (CorA) is active against Gram-positive bacteria and targets the switch region of RNA polymerase. Because of the high frequency of mutation (FoM) leading to rifampicin resistance, we determined the CorA FoM in S. aureus using fluctuat
Externí odkaz:
https://doaj.org/article/f755728120db4450ac61d370364e0082
Autor:
Andrea Schiefer, Marc P Hübner, Anna Krome, Christine Lämmer, Alexandra Ehrens, Tilman Aden, Marianne Koschel, Helene Neufeld, Lillibeth Chaverra-Muñoz, Rolf Jansen, Stefan Kehraus, Gabriele M König, Domen Pogorevc, Rolf Müller, Marc Stadler, Stephan Hüttel, Thomas Hesterkamp, Karl Wagner, Kenneth Pfarr, Achim Hoerauf
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 12, p e0008930 (2020)
Current efforts to eliminate the neglected tropical diseases onchocerciasis and lymphatic filariasis, caused by the filarial nematodes Onchocerca volvulus and Wuchereria bancrofti or Brugia spp., respectively, are hampered by lack of a short-course m
Externí odkaz:
https://doaj.org/article/d4370a71cad149209e66761eb918df85
Autor:
Anna K. Krome, Tim Becker, Stefan Kehraus, Andrea Schiefer, Christian Steinebach, Tilman Aden, Stefan J. Frohberger, Álvaro López Mármol, Dnyaneshwar Kapote, Rolf Jansen, Lillibeth Chaverra-Muñoz, Marc P. Hübner, Kenneth Pfarr, Thomas Hesterkamp, Marc Stadler, Michael Gütschow, Gabriele M. König, Achim Hoerauf, Karl G. Wagner
Publikováno v:
Pharmaceutics, Vol 12, Iss 11, p 1105 (2020)
Novel-antibiotics are urgently needed to combat an increase in morbidity and mortality due to resistant bacteria. The preclinical candidate corallopyronin A (CorA) is a potent antibiotic against Gram-positive and some Gram-negative pathogens for whic
Externí odkaz:
https://doaj.org/article/e03acd88b74a4c9d8c536584505e42ed
Autor:
Alexandra Ehrens, Andrea Schiefer, Anna K. Krome, Tim Becker, Katharina Rox, Helene Neufeld, Tilman Aden, Karl G. Wagner, Rolf Müller, Miriam Grosse, Marc Stadler, Gabriele M. König, Stefan Kehraus, Silke Alt, Thomas Hesterkamp, Marc Peter Hübner, Kenneth Pfarr, Achim Hoerauf
Publikováno v:
Frontiers in Tropical Diseases. 3
Corallopyronin A (CorA), a natural product antibiotic of Corallococcus coralloides, inhibits the bacterial DNA-dependent RNA polymerase. It is active against the essential Wolbachia endobacteria of filarial nematodes, preventing development, causing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e66de99122731014d88f75de028823d4
https://doi.org/10.3389/fitd.2022.983107
https://doi.org/10.3389/fitd.2022.983107
Autor:
Marc Stadler, Andrea Schiefer, Kenneth Pfarr, Rolf Jansen, Tim Becker, Gabriele M. König, Tilman Aden, Michael Gütschow, Marc P. Hübner, Christian Steinebach, Álvaro López Mármol, Dnyaneshwar N. Kapote, Achim Hoerauf, Anna K. Krome, Stefan J. Frohberger, Stefan Kehraus, Thomas Hesterkamp, Lillibeth Chaverra-Muñoz, Karl G. Wagner
Publikováno v:
Pharmaceutics
Switzerland
Volume 12
Issue 11
Pharmaceutics, Vol 12, Iss 1105, p 1105 (2020)
Switzerland
Volume 12
Issue 11
Pharmaceutics, Vol 12, Iss 1105, p 1105 (2020)
Novel-antibiotics are urgently needed to combat an increase in morbidity and mortality due to resistant bacteria. The preclinical candidate corallopyronin A (CorA) is a potent antibiotic against Gram-positive and some Gram-negative pathogens for whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98f7b11df4e44d23d096970ff14d1fb9
http://europepmc.org/articles/PMC7698778
http://europepmc.org/articles/PMC7698778
Corallopyronin A for short-course anti-wolbachial, macrofilaricidal treatment of filarial infections
Autor:
Stephan Hüttel, Marc Stadler, Marc P. Hübner, Stefan Kehraus, Rolf Jansen, Gabriele M. König, Tilman Aden, Alexandra Ehrens, Andrea Schiefer, Helene Neufeld, Achim Hoerauf, Anna K. Krome, Christine Lämmer, Lillibeth Chaverra-Muñoz, Thomas Hesterkamp, Marianne Koschel, Karl G. Wagner, Domen Pogorevc, Rolf Müller, Kenneth Pfarr
Publikováno v:
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 14, Iss 12, p e0008930 (2020)
e0008930
PLoS neglected tropical diseases
United States
PLoS Neglected Tropical Diseases, Vol 14, Iss 12, p e0008930 (2020)
e0008930
PLoS neglected tropical diseases
United States
Current efforts to eliminate the neglected tropical diseases onchocerciasis and lymphatic filariasis, caused by the filarial nematodes Onchocerca volvulus and Wuchereria bancrofti or Brugia spp., respectively, are hampered by lack of a short-course m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b6a284261db94a0247df4d0174fccf2
https://pubmed.ncbi.nlm.nih.gov/33284808
https://pubmed.ncbi.nlm.nih.gov/33284808
Autor:
Rox, Katharina1,2 (AUTHOR) katharina.rox@helmholtz-hzi.de, Becker, Tim3,4 (AUTHOR), Schiefer, Andrea4,5 (AUTHOR), Grosse, Miriam2,6 (AUTHOR), Ehrens, Alexandra4,5 (AUTHOR), Jansen, Rolf6 (AUTHOR), Aden, Tilman4,5 (AUTHOR), Kehraus, Stefan4,7 (AUTHOR), König, Gabriele M.4,7 (AUTHOR), Krome, Anna K.3,4 (AUTHOR), Hübner, Marc P.4,5 (AUTHOR), Wagner, Karl G.3,4 (AUTHOR), Stadler, Marc2,6 (AUTHOR), Pfarr, Kenneth4,5 (AUTHOR) katharina.rox@helmholtz-hzi.de, Hoerauf, Achim4,5 (AUTHOR) katharina.rox@helmholtz-hzi.de
Publikováno v:
Pharmaceutics. Jan2023, Vol. 15 Issue 1, p131. 13p.
Autor:
Becker, Tim1,2 (AUTHOR), Krome, Anna K.1,2,3 (AUTHOR), Vahdati, Sahel1 (AUTHOR), Schiefer, Andrea2,3 (AUTHOR), Pfarr, Kenneth2,3 (AUTHOR), Ehrens, Alexandra2,3 (AUTHOR), Aden, Tilman3 (AUTHOR), Grosse, Miriam4,5 (AUTHOR), Jansen, Rolf4,5 (AUTHOR), Alt, Silke6 (AUTHOR), Hesterkamp, Thomas6 (AUTHOR), Stadler, Marc4,5 (AUTHOR), Hübner, Marc P.2,3 (AUTHOR), Kehraus, Stefan2,7 (AUTHOR), König, Gabriele M.2,7 (AUTHOR), Hoerauf, Achim2,3 (AUTHOR), Wagner, Karl G.1,2 (AUTHOR) karl.wagner@uni-bonn.de
Publikováno v:
Pharmaceutics. Aug2022, Vol. 14 Issue 8, p1657-1657. 18p.