Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Tilman, Borggrefe"'
Autor:
Andreas Herchenröther, Stefanie Gossen, Tobias Friedrich, Alexander Reim, Nadine Daus, Felix Diegmüller, Jörg Leers, Hakimeh Moghaddas Sani, Sarah Gerstner, Leah Schwarz, Inga Stellmacher, Laura Victoria Szymkowiak, Andrea Nist, Thorsten Stiewe, Tilman Borggrefe, Matthias Mann, Joel P. Mackay, Marek Bartkuhn, Annette Borchers, Jie Lan, Sandra B. Hake
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
How the histone variant H2A.Z controls cell fate remains unclear. Here, the authors reveal that the H2A.Z interacting partner HMG20A plays a key role in regulating transcription during early head and heart development.
Externí odkaz:
https://doaj.org/article/0637b8d8470142babbb8a8e3dc3bbf4c
Autor:
Nastasja Merle, Sabrina Elmshäuser, Florian Strassheimer, Michael Wanzel, Alexander M. König, Julianne Funk, Michelle Neumann, Katharina Kochhan, Frederik Helmprobst, Axel Pagenstecher, Andrea Nist, Marco Mernberger, André Schneider, Thomas Braun, Tilman Borggrefe, Rajkumar Savai, Oleg Timofeev, Thorsten Stiewe
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-22 (2022)
Abstract Background In vivo gene editing of somatic cells with CRISPR nucleases has facilitated the generation of autochthonous mouse tumors, which are initiated by genetic alterations relevant to the human disease and progress along a natural timeli
Externí odkaz:
https://doaj.org/article/d980d18d5f1b484f966f534df0c944fb
Autor:
Francesca Ferrante, Benedetto Daniele Giaimo, Tobias Friedrich, Toshiya Sugino, Daniel Mertens, Sabrina Kugler, Bernd Martin Gahr, Steffen Just, Leiling Pan, Marek Bartkuhn, Michael Potente, Franz Oswald, Tilman Borggrefe
Publikováno v:
Cell Death and Disease, Vol 13, Iss 7, Pp 1-9 (2022)
Abstract Notch signaling plays a pivotal role in the development and, when dysregulated, it contributes to tumorigenesis. The amplitude and duration of the Notch response depend on the posttranslational modifications (PTMs) of the activated NOTCH rec
Externí odkaz:
https://doaj.org/article/e94caf3b118449feae916a319b8e5115
Autor:
Teresa Robert-Finestra, Beatrice F. Tan, Hegias Mira-Bontenbal, Erika Timmers, Cristina Gontan, Sarra Merzouk, Benedetto Daniele Giaimo, François Dossin, Wilfred F. J. van IJcken, John W. M. Martens, Tilman Borggrefe, Edith Heard, Joost Gribnau
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
SPEN is a key player in initiation of X chromosome inactivation. Here, the authors show that SPEN is required for Xist-mediated silencing of its own antisense regulator Tsix.
Externí odkaz:
https://doaj.org/article/f9c3bed8f0db4091b5ce5fa62f64d44c
Autor:
Małgorzata Sotomska, Robert Liefke, Francesca Ferrante, Heiko Schwederski, Franz Oswald, Tilman Borggrefe
Publikováno v:
Epigenetics & Chromatin, Vol 14, Iss 1, Pp 1-15 (2021)
Abstract Background Notch signaling controls cell fate decisions in many contexts during development and adult stem cell homeostasis and, when dysregulated, leads to carcinogenesis. The central transcription factor RBPJ assembles the Notch coactivato
Externí odkaz:
https://doaj.org/article/6d3e69a6d2c64db095512c7cbf7fe9f2
Autor:
Ellen K Gagliani, Lisa M Gutzwiller, Yi Kuang, Yoshinobu Odaka, Phillipp Hoffmeister, Stefanie Hauff, Aleksandra Turkiewicz, Emily Harding-Theobald, Patrick J Dolph, Tilman Borggrefe, Franz Oswald, Brian Gebelein, Rhett A Kovall
Publikováno v:
PLoS Genetics, Vol 18, Iss 8, p e1010335 (2022)
Notch signaling is a conserved pathway that converts extracellular receptor-ligand interactions into changes in gene expression via a single transcription factor (CBF1/RBPJ in mammals; Su(H) in Drosophila). In humans, RBPJ variants have been linked t
Externí odkaz:
https://doaj.org/article/3d3ef8ff2e0245a7bfb1cb014a49f333
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 7, Iss 1, Pp 1-2 (2022)
Externí odkaz:
https://doaj.org/article/25975dc79c764028a201b22db72cf816
Autor:
Rodrigo Diéguez-Hurtado, Katsuhiro Kato, Benedetto Daniele Giaimo, Melina Nieminen-Kelhä, Hendrik Arf, Francesca Ferrante, Marek Bartkuhn, Tobias Zimmermann, M. Gabriele Bixel, Hanna M. Eilken, Susanne Adams, Tilman Borggrefe, Peter Vajkoczy, Ralf H. Adams
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
Pericytes are perivascular cells essential for blood-brain barrier maintenance. Here Diéguez-Hurtado et al. show that depletion of the transcription factor RBPJ in pericytes affects their molecular identity and disturbs endothelial cell behaviour, i
Externí odkaz:
https://doaj.org/article/7f0f3111c1374c77bebde1826c430b67
Autor:
Benedetto Daniele Giaimo, Francesca Ferrante, Andreas Herchenröther, Sandra B. Hake, Tilman Borggrefe
Publikováno v:
Epigenetics & Chromatin, Vol 12, Iss 1, Pp 1-22 (2019)
Abstract The histone variant H2A.Z is involved in several processes such as transcriptional control, DNA repair, regulation of centromeric heterochromatin and, not surprisingly, is implicated in diseases such as cancer. Here, we review the recent dev
Externí odkaz:
https://doaj.org/article/ed61ab6b1cc341758a41c4005dc851bd
Autor:
Lisa Frankenreiter, Bernd M. Gahr, Hannes Schmid, Mirjam Zimmermann, Sebastian Deichsel, Philipp Hoffmeister, Aleksandra Turkiewicz, Tilman Borggrefe, Franz Oswald, Anja C. Nagel
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
The highly conserved Notch signaling pathway controls a multitude of developmental processes including hematopoiesis. Here, we provide evidence for a novel mechanism of tissue-specific Notch regulation involving phosphorylation of CSL transcription f
Externí odkaz:
https://doaj.org/article/1dc96dd13eb84d14a5b10673ca6bc5a5