Výsledky vyhledávání - "Tilly W. Hulscher"

6-Mercaptopurine: Cytotoxicity and biochemical pharmacology in human malignant T-lymphoblasts

Autor: E. H. Stet, Frank J.M. Damen, Marinka A.H. Bakker, John A. Van Baal, Jos P.M. Bökkerink, Tilly W. Hulscher, Ronney A. De Abreu

Publikováno v: Biochemical Pharmacology. 45:1455-1463

The effects of prolonged exposure to 2 and 10 μM 6-mercaptopurine (6MP) in the human lymphoblastic T-cell line MOLT-4 were studied with respect to cell-kinetic parameters, phosphoribosyi pyrophosphate (PRPP) and purine ribonucleotide levels, formati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24c206704d0893a12a2fdba0e1fa247c
https://doi.org/10.1016/0006-2952(93)90045-x

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Influence of Methotrexate on Purine and Pyrimidine Pools and on Cell Phase Distribution of Cultured Human Lymphoblasts

Autor: Jos P.M. Bökkerink, Tilly W. Hulscher, John M. van Baal, Ronney A. De Abreu, E. D. A. M. Schretlen, Chris H. M. M. de Bruijn, Marinka A.H. Bakker

Publikováno v: Purine and Pyrimidine Metabolism in Man V ISBN: 9781468412505

Methotrexate (MTX) and 6-mercaptopurine (6MP) are among the most commonly used agents in the maintenance treatment of acute lymphoblastic leukemia (ALL) in children.1-3 There are biochemical considerations for an increased efficacy of a combination o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dd97e8c597cf4ce043a3e7bc2a8d4507
https://doi.org/10.1007/978-1-4684-1248-2_17

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Synergy of Methotrexate and 6-Mercaptopurine on Cell Growth and Clono- Genicity of Cultured Human T-Lymphoblasts

Autor: Tilly W. Hulscher, Gerard A. M. de Vaan, Ronney A. De Abreu, E. D. A. M. Schretlen, Marinka A.H. Bakker, Jos P.M. Bökkerink, Chris H. M. M. de Bruijn

Publikováno v: Purine and Pyrimidine Metabolism in Man V ISBN: 9781468412505

Methotrexate (MTX) is a well known inhibitor of purine de novo synthesis and thymidylate synthesis. In cells with an active purine de novo synthesis 5-phosphoribosyl-1-pyrophosphate (PRPP) levels are increased significantly, when the cells are expose

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7c4acd449ddacf6a321af096366d5743
https://doi.org/10.1007/978-1-4684-1248-2_20

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Increased Availability of Phosphoribosyl Pyrophosphate as the Basis for Enhanced 6-Mercaptopurine Incorporation by Methotrexate, in Cultured Human Lymphoblasts

Autor: Jos P.M. Bökkerink, Ronney A. De Abreu, Chris H. M. M. de Bruijn, Tilly W. Hulscher, Marinka A.H. Bakker, E. D. A. M. Schretlen, Jan P R M Van Laarhoven

Publikováno v: Purine and Pyrimidine Metabolism in Man V ISBN: 9781468412505

In response to inhibition of purine de novo biosynthesis by methotrexate (MTX), an increase in the availability of 5-phosphoribosyl-1-pyrophosphate (PRPP) occurs. As a result of this increased availability of PRPP, potentiation of 6-mercaptopurine (6

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eb58d90e2a2890063d5c1efc59840f02
https://doi.org/10.1007/978-1-4684-1248-2_21

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Purine de novo synthesis as the basis of synergism of methotrexate and 6-mercaptopurine in human malignant lymphoblasts of different lineages

Autor: Tilly W. Hulscher, E. D. A. M. Schretlen, Marinka A.H. Bakker, Ronney A. De Abreu, Jos P.M. Bökkerink

Publikováno v: Biochemical pharmacology. 37(12)

Methotrexate (MTX) causes an inhibition of purine de novo synthesis (PDNS), resulting in increased intracellular availability of 5-phosphoribosyl-1-pyrophosphate (PRPP) in human malignant lymphoblasts with an active PDNS. Normal bone marrow cells and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48fdf8a99121524648bbc622529ff54b
https://pubmed.ncbi.nlm.nih.gov/2455519

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Effects of methotrexate on purine and pyrimidine metabolism and cell-kinetic parameters in human malignant lymphoblasts of different lineages

Autor: Tilly W. Hulscher, Ronney A. De Abreu, Chris H. M. M. de Bruijn, Marinka A.H. Bakker, Jos P.M. Bökkerink, E. D. A. M. Schretlen, John M. van Baal

Publikováno v: Biochemical pharmacology. 37(12)

MOLT-4 (T−), RAJI (B−), and KM-3 (non-B-non-T-, common ALL) malignant lymphoblasts demonstrated significant differences in their activities of purine de novo synthesis (PDNS) and purine salvage pathway and in their cell-kinetic parameters. Incuba

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ba7081333530985d3e167de9c5a4dd8
https://pubmed.ncbi.nlm.nih.gov/2455520

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The effect of methotrexate on purine and pyrimidine deoxyribonucleoside triphosphate pools and on cell viability and cell-phase distribution in malignant human T- and B-lymphoblasts

Autor: Tilly W. Hulscher, John M. van Baal, Ronney A. De Abreu, Marinka A.H. Bakker, Jos P.M. Bökkerink

Publikováno v: The Role of Pharmacology in Pediatric Oncology ISBN: 9789401083959

Methotrexate (MTX) and 6-mercaptopurine (6-MP) are widely used in the maintenance treatment of acute lymphoblastic leukemia (ALL) in children. Based on their biochemical interactions there are reasons to support a combination therapy of both drugs. M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::766cbf6b7e4a44e2ae75ffd0ae60a320
https://doi.org/10.1007/978-94-009-4267-7_14

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Autor: Ronney A. De Abreu, Gerard A. M. de Vaan, Jos P.M. Bökkerink, Tilly W. Hulscher, Marinka A.H. Bakker, John M. van Baal

Publikováno v: Biochemical pharmacology. 35(20)

The effects of methotrexate (MTX) on cytotoxicity (trypan blue exclusion and soft agar clonal growth), cell cycle perturbation, and purine and pyrimidine ribonucleotide and deoxyribonucleotide pools have been studied in MOLT-4 malignant T-lymphoblast

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b02a98a7050991b89f870943fbcf0d7b
https://pubmed.ncbi.nlm.nih.gov/2429668

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INCREASED AVAILABILITY OF PHOSPHORIBOSYL PYROPHOSPHATE AS THE BASIS FOR ENHANCED 6-MERCAPTOPURINE INCORPORATION BY METHOTREXATE, IN CULTURED HUMAN LYMPHOBLASTS: 52

Autor: Tilly W. Hulscher, Jos P.M. Bökkerink, Gerard A. M. de Vaan, Ronney A. De Abreu, Marinka A.H. Bakker, E. D. A. M. Schretlen, Chris H.M.M. De Bruyn

Publikováno v: Pediatric Research. 19:752-752

In this study we have examined the inhibition of purine de novo synthesis by methotrexate (MTX), with concommitant increase of intracellular PRPP concentrations and enhancement of 6-mercaptopurine (6MP) incorporation. We found a significant elevation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::50ef1eb5f67f7789cd76f7854029d57a
https://doi.org/10.1203/00006450-198507000-00072

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