Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Tilly Ping"'
Publikováno v:
British Journal of Pharmacology. 153:1177-1184
Background and purpose: An oral, single dose of 7.5 mg kg−1 of unfractionated heparin (UFH) reduces thrombosis by 50% in a rat model of venous thrombosis. As long-term use is required clinically, our objectives were to study the antithrombotic effe
Publikováno v:
Biomedicine & Pharmacotherapy. 58:372-380
Heparins are antithrombotic drugs given by intravenous and subcutaneous routes. However, we have observed that heparins have antithrombotic activity in a rat model when administered orally despite low plasma levels, with low molecular weight heparins
Publikováno v:
International Journal of Radiation Biology. 79:107-118
Purpose : Alpha-radiation from polonium-210 (210 Po) can elevate background radiation dose by an order of magnitude in people consuming large quantities of meat and seafood, particularly caribou and reindeer. Because up to 50% of the ingested 210 Po
Autor:
Linda M Hiebert, Sandra M Wice, Tilly Ping, Ronald E Hileman, Ishan Capila, Robert J Linhardt
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 78:307-320
Distribution and antithrombotic activity of orally administered unfractionated porcine heparin were studied. [14C]Heparin was prepared by de-N-acetylation of porcine mucosal heparin followed by re-N-acetylation, using [14C]acetic anhydride. [14C]Hepa
Publikováno v:
Pathophysiology of Haemostasis and Thrombosis. 30:196-203
Previous studies in rats demonstrated that orally administered, unfractionated bovine lung heparin is absorbed and has a dose-dependent antithrombotic effect. The objective of this study was to determine if an oral low molecular weight heparin had a
Autor:
Sandra M. Wice, Ishan Capila, Linda M. Hiebert, Ronald E. Hileman, Robert J. Linhardt, Tilly Ping
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 78:307-320
Distribution and antithrombotic activity of orally administered unfractionated porcine heparin were studied. [14C]Heparin was prepared by de-N-acetylation of porcine mucosal heparin followed by re-N-acetylation, using [14C]acetic anhydride. [14C]Hepa
Autor:
Linda M. Hiebert, Tilly Ping
Publikováno v:
Journal of Molecular and Cellular Cardiology. 29:229-235
Studies in our laboratory have demonstrated that addition of polyanions, heparin or dextran sulfate, to endothelial cell cultures decrease free radical injury. To determine if these polyanions had a similar effect on cardiomyocytes, models of free ra
Publikováno v:
Journal of cardiovascular pharmacology and therapeutics. 17(1)
Although heparins are usually injected intravenously or subcutaneously, antithrombotic activity is observed in rat models following single oral heparin doses. Since repetitive dosing is usually needed for thromboprophylaxis, study objectives were to
Publikováno v:
The Journal of laboratory and clinical medicine. 145(3)
Although heparin is not generally administered orally, the results of studies involving rats suggest that heparin is absorbed, with low levels in plasma but extensive distribution to the endothelium. To determine whether evidence of absorption after
Publikováno v:
Thrombosis and haemostasis. 85(1)
SummaryPrevious studies in rats show that unfractionated heparin and the low molecular weight heparin logiparin have a dose-dependent antithrombotic effect and are found in endothelium and plasma when administered orally. Objectives of the present st