Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Till S Voss"'
Autor:
Eva Hitz, Natalie Wiedemar, Armin Passecker, Beatriz A S Graça, Christian Scheurer, Sergio Wittlin, Nicolas M B Brancucci, Ioannis Vakonakis, Pascal Mäser, Till S Voss
Publikováno v:
PLoS Biology, Vol 19, Iss 12, p e3001483 (2021)
Cyclic adenosine monophosphate (cAMP)-dependent protein kinase A (PKA) signalling is essential for the proliferation of Plasmodium falciparum malaria blood stage parasites. The mechanisms regulating the activity of the catalytic subunit PfPKAc, howev
Externí odkaz:
https://doaj.org/article/413e0f8e7b194959ad8aefaffac57cbd
Publikováno v:
mSphere, Vol 9, Iss 11 (2024)
ABSTRACT The malaria parasite Plasmodium falciparum employs antigenic variation of the virulence factor P. falciparum erythrocyte membrane protein 1 (PfEMP1) to escape adaptive immune responses during blood infection. Antigenic variation of PfEMP1 oc
Externí odkaz:
https://doaj.org/article/0caf02a1ac834e9799f7244f9e4df126
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e100183 (2014)
Clonally variant protein expression in the malaria parasite Plasmodium falciparum generates phenotypic variability and allows isogenic populations to adapt to environmental changes encountered during blood stage infection. The underlying regulatory m
Externí odkaz:
https://doaj.org/article/e6c2a9c9fc24425da696484299b14df8
Autor:
Matthias Wyss, Basil T. Thommen, Jacob Kofler, Eilidh Carrington, Nicolas M. B. Brancucci, Till S. Voss
Publikováno v:
mSphere, Vol 9, Iss 9 (2024)
ABSTRACT Aurora kinases are crucial regulators of mitotic cell cycle progression in eukaryotes. The protozoan malaria parasite Plasmodium falciparum replicates via schizogony, a specialized mode of cell division characterized by consecutive asynchron
Externí odkaz:
https://doaj.org/article/2df59e2b4e4f4dd483515d62797913cf
Publikováno v:
PLoS Pathogens, Vol 8, Iss 12, p e1002943 (2012)
Externí odkaz:
https://doaj.org/article/1be6a386cf50402bad91f695ceb81140
Autor:
Christian Flueck, Richard Bartfai, Igor Niederwieser, Kathrin Witmer, Blaise T F Alako, Suzette Moes, Zbynek Bozdech, Paul Jenoe, Hendrik G Stunnenberg, Till S Voss
Publikováno v:
PLoS Pathogens, Vol 6, Iss 2, p e1000784 (2010)
The heterochromatic environment and physical clustering of chromosome ends at the nuclear periphery provide a functional and structural framework for antigenic variation and evolution of subtelomeric virulence gene families in the malaria parasite Pl
Externí odkaz:
https://doaj.org/article/95c4538f4381497695e3a563a6a826de
Autor:
Christian Flueck, Richard Bartfai, Jennifer Volz, Igor Niederwieser, Adriana M Salcedo-Amaya, Blaise T F Alako, Florian Ehlgen, Stuart A Ralph, Alan F Cowman, Zbynek Bozdech, Hendrik G Stunnenberg, Till S Voss
Publikováno v:
PLoS Pathogens, Vol 5, Iss 9, p e1000569 (2009)
Epigenetic processes are the main conductors of phenotypic variation in eukaryotes. The malaria parasite Plasmodium falciparum employs antigenic variation of the major surface antigen PfEMP1, encoded by 60 var genes, to evade acquired immune response
Externí odkaz:
https://doaj.org/article/e1d2f463331d449e97b5a27061d5a101
Autor:
Christopher J Tonkin, Céline K Carret, Manoj T Duraisingh, Till S Voss, Stuart A Ralph, Mirja Hommel, Michael F Duffy, Liliana Mancio da Silva, Artur Scherf, Alasdair Ivens, Terence P Speed, James G Beeson, Alan F Cowman
Publikováno v:
PLoS Biology, Vol 7, Iss 4, p e84 (2009)
Cytoadherance of Plasmodium falciparum-infected erythrocytes in the brain, organs and peripheral microvasculature is linked to morbidity and mortality associated with severe malaria. Parasite-derived P. falciparum Erythrocyte Membrane Protein 1 (PfEM
Externí odkaz:
https://doaj.org/article/39d35c51578e4af19b3a93002aacacda
Autor:
Aline Freville, Lindsay B. Stewart, Kevin K. A. Tetteh, Moritz Treeck, Alfred Cortes, Till S. Voss, Sarah J. Tarr, David A. Baker, David J. Conway
Publikováno v:
mBio, Vol 15, Iss 5 (2024)
ABSTRACTThe Plasmodium falciparum merozoite surface protein MSPDBL2 is a polymorphic antigen targeted by acquired immune responses, and normally expressed in only a minority of mature schizonts. The potential relationship of MSPDBL2 to sexual commitm
Externí odkaz:
https://doaj.org/article/a3c074ac2bf04bf99c760a62f54b71a2
Autor:
Lukas Meier, Marina Antillon, Christian Burri, Nakul Chitnis, Yvette Endriss, Jennifer Keiser, Sarah Moore, Pie Müller, Melissa Penny, Till S. Voss, Pascal Mäser, Jürg Utzinger
Publikováno v:
CHIMIA, Vol 77, Iss 9 (2023)
In pursuing novel therapeutic solutions, drug discovery and development rely on efficiently utilising existing knowledge and resources. Repurposing know-how, a strategy that capitalises on previously acquired information and expertise, has emerged as
Externí odkaz:
https://doaj.org/article/893f70b540d3482ca499ff5f9881f1c1