Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Till S Voss"'
Publikováno v:
mSphere, Vol 9, Iss 11 (2024)
ABSTRACT The malaria parasite Plasmodium falciparum employs antigenic variation of the virulence factor P. falciparum erythrocyte membrane protein 1 (PfEMP1) to escape adaptive immune responses during blood infection. Antigenic variation of PfEMP1 oc
Externí odkaz:
https://doaj.org/article/0caf02a1ac834e9799f7244f9e4df126
Autor:
Matthias Wyss, Basil T. Thommen, Jacob Kofler, Eilidh Carrington, Nicolas M. B. Brancucci, Till S. Voss
Publikováno v:
mSphere, Vol 9, Iss 9 (2024)
ABSTRACT Aurora kinases are crucial regulators of mitotic cell cycle progression in eukaryotes. The protozoan malaria parasite Plasmodium falciparum replicates via schizogony, a specialized mode of cell division characterized by consecutive asynchron
Externí odkaz:
https://doaj.org/article/2df59e2b4e4f4dd483515d62797913cf
Autor:
Aline Freville, Lindsay B. Stewart, Kevin K. A. Tetteh, Moritz Treeck, Alfred Cortes, Till S. Voss, Sarah J. Tarr, David A. Baker, David J. Conway
Publikováno v:
mBio, Vol 15, Iss 5 (2024)
ABSTRACTThe Plasmodium falciparum merozoite surface protein MSPDBL2 is a polymorphic antigen targeted by acquired immune responses, and normally expressed in only a minority of mature schizonts. The potential relationship of MSPDBL2 to sexual commitm
Externí odkaz:
https://doaj.org/article/a3c074ac2bf04bf99c760a62f54b71a2
Autor:
Lukas Meier, Marina Antillon, Christian Burri, Nakul Chitnis, Yvette Endriss, Jennifer Keiser, Sarah Moore, Pie Müller, Melissa Penny, Till S. Voss, Pascal Mäser, Jürg Utzinger
Publikováno v:
CHIMIA, Vol 77, Iss 9 (2023)
In pursuing novel therapeutic solutions, drug discovery and development rely on efficiently utilising existing knowledge and resources. Repurposing know-how, a strategy that capitalises on previously acquired information and expertise, has emerged as
Externí odkaz:
https://doaj.org/article/893f70b540d3482ca499ff5f9881f1c1
Autor:
Lindsay B. Stewart, Aline Freville, Till S. Voss, David A. Baker, Gordon A. Awandare, David J. Conway
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 6 (2022)
ABSTRACT Asexual blood-stage malaria parasites must produce sexual progeny to infect mosquitoes. It is important to understand the scope and causes of intraspecific variation in sexual commitment rates, particularly for the major human parasite P. fa
Externí odkaz:
https://doaj.org/article/c945b530d1bd487fa6c592d91ace00d6
Autor:
Sylwia D. Boltryk, Armin Passecker, Arne Alder, Eilidh Carrington, Marga van de Vegte-Bolmer, Geert-Jan van Gemert, Alex van der Starre, Hans-Peter Beck, Robert W. Sauerwein, Taco W. A. Kooij, Nicolas M. B. Brancucci, Nicholas I. Proellochs, Tim-Wolf Gilberger, Till S. Voss
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
During each replication cycle of P. falciparum in the human bloodstream, a small proportion of parasites commits to sexual development and differentiates into transmission-relevant gametocytes. Applying CRISPR-based genome editing, Boltryk et al. eng
Externí odkaz:
https://doaj.org/article/bdde91798fe34a80b40c88b2bfa92cdd
Autor:
Felix Evers, Alfredo Cabrera-Orefice, Dei M. Elurbe, Mariska Kea-te Lindert, Sylwia D. Boltryk, Till S. Voss, Martijn A. Huynen, Ulrich Brandt, Taco W. A. Kooij
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Applying complexome profiling, Evers et al. unravel the composition of mitochondrial oxidative phosphorylation complexes in P. falciparum asexual and sexual blood stages. Abundance of these complexes differs between both stages, supporting the hypoth
Externí odkaz:
https://doaj.org/article/84175595e535442092eacbb5b96bf88c
Autor:
Eva Hitz, Olivia Grüninger, Armin Passecker, Matthias Wyss, Christian Scheurer, Sergio Wittlin, Hans-Peter Beck, Nicolas M. B. Brancucci, Till S. Voss
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Hitz et al. describe the role of the protein kinase PfCK2α in the development of the human malaria parasite Plasmodium falciparum. Using mutant parasites, they show that PfCK2α is not only essential for asexual but also sexual development of P. fal
Externí odkaz:
https://doaj.org/article/a968a781e2a9433ca72783a35e1bac0a
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Abstract In malaria parasites, male gametogenesis is a proliferative stage essential for parasite transmission to the mosquito vector. It is a rapid process involving three rounds of genome replication alternating with closed endomitoses, and assembl
Externí odkaz:
https://doaj.org/article/fb3e8f58565243c88594bb8e0d571e74
Autor:
Basil T. Thommen, Armin Passecker, Tamara Buser, Eva Hitz, Till S. Voss, Nicolas M. B. Brancucci
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Malaria parasites rely on specialized stages, called gametocytes, to ensure human-to-human transmission. The formation of these sexual precursor cells is initiated by commitment of blood stage parasites to the sexual differentiation pathway. Plasmodi
Externí odkaz:
https://doaj.org/article/897f8694013d48ac89eaf7c8dc2889d8