Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

Autor: Jens Treutlein, James B. Potash, Cheynna A. Crowley, Paul F. O'Reilly, Francis M. Mondimore, Nicholas G. Martin, Jodie N. Painter, Qingqin S. Li, Tõnu Esko, Michael Conlon O'Donovan, Markus M. Nöthen, Toni-Kim Clarke, Roseann E. Peterson, Shantel Weinsheimer, Naomi R. Wray, Marie Bækvad-Hansen, Pamela F.A. Madden, Johannes H. Smit, Gonneke Willemsen, Thomas Hansen, Andrew C. Heath, Carsten Horn, Udo Dannlowski, Fulai Jin, Robert A. Schoevers, Jian Yang, Nicholas Eriksson, Marianne Giørtz Pedersen, Patrik K. E. Magnusson, Hans J. Grabe, Michael Gill, Lili Milani, Caroline Hayward, Shaun Purcell, Stanley I. Shyn, Penelope A. Lind, Giorgio Pistis, Michel G. Nivard, Thorgeir E. Thorgeirsson, Abdel Abdellaoui, Andres Metspalu, David J. Porteous, Anders D. Børglum, Christine Søholm Hansen, Scott D. Gordon, Nicholas John Craddock, Susanne Lucae, Douglas Blackwood, Jürgen Wellmann, Till M.F. Andlauer, Wesley K. Thompson, Chao Tian, Rudolf Uher, Nese Direk, Yuri Milaneschi, Paola Giusti-Rodríguez, Rick Jansen, Marcus Ising, Yang Wu, Jesper Krogh, Merete Nordentoft, Jouke-Jan Hottenga, Robert Maier, Ming Hu, Kari Stefansson, Glyn Lewis, Peter McGuffin, Wolfgang Maier, Erin C. Dunn, Bradley T. Webb, Gerome Breen, Henning Teismann, Eric Jorgenson, Jorge A. Quiroz, Brenda W.J.H. Penninx, Jonas Bybjerg-Grauholm, Warren W. Kretzschmar, Dean F. MacKinnon, Craig A. Stockmeier, Wouter J. Peyrot, Enrico Domenici, E. C.J. De Geus, Alexander Teumer, Henry Völzke, Yihan Li, Michael John Owen, Manuel Mattheisen, Bernard Ng, Baptiste Couvy-Duchesne, Daniel J. Smith, Jana Strohmaier, Vassily Trubetskoy, Volker Arolt, Douglas F. Levinson, Futao Zhang, Daniel Umbricht, Aartjan F.T. Beekman, David A. Hinds, Bernhard T. Baune, Henning Tiemeier, Hualin S. Xi, Hamdi Mbarek, Steven P. Hamilton, Stefan Kloiber, Fernando S. Goes, Jianxin Shi, Marcella Rietschel, Dale R. Nyholt, Zoltán Kutalik, Niamh Mullins, Grant W. Montgomery, Henriette N. Buttenschøn, Georg Homuth, Katharina Domschke, Alexander Viktorin, Hilary K. Finucane, Ashley R. Winslow, Saira Saeed Mirza, Fabian Streit, Erik Pettersson, Martin Preisig, Danielle Posthuma, Stephan Ripke, Lucía Colodro-Conde, Thalia C. Eley, Pippa A. Thomson, Thomas Werge, Enrique Castelao, Klaus Berger, Yun Li, Stacy Steinberg, Dorret I. Boomsma, Matthias Nauck, Sara Mostafavi, Jacqueline M. Lane, Katherine E. Tansey, Divya Mehta, Gregory E. Crawford, Andreas J. Forstner, Jane H. Christensen, Silviu Alin Bacanu, Julia Kraft, David M. Hougaard, Peter M. Visscher, Valentina Escott-Price, Donald J. MacIntyre, Sarah E. Medland, Per Qvist, Kenneth S. Kendler, Jordan W. Smoller, J. Raymond DePaulo, Ian J. Deary, Thomas G. Schulze, Julien Bryois, Ian B. Hickie, Helena Gaspar, Jonathan Mill, James A. Knowles, Cathryn M. Lewis, Hassan S. Dashti, Stefan Herms, Margarita Rivera, John P. Rice, Lynsey S. Hall, Eilis Hannon, Nancy L. Pedersen, Eva C. Schulte, Hreinn Stefansson, Maciej Trzaskowski, André G. Uitterlinden, Bertram Müller-Myhsok, Gail Davies, Mark Adams, Jakob Grove, Eske M. Derks, Sven Cichon, Jonathan I.R. Coleman, Sandra Van der Auwera, Myrna M. Weissman, Preben Bo Mortensen, Josef Frank, Enda M. Byrne, Esben Agerbo, Engilbert Sigurdsson, Xiaoxiao Liu, Patrick F. Sullivan, Carsten Bøcker Pedersen, Ole Mors, Catherine Schaefer, Richa Saxena, Albert M. van Hemert, Jonathan Marchini, Hogni Oskarsson, Franziska Degenhardt, Tracy Air, Elisabeth B. Binder, Christel M. Middeldorp, Farnush Hassan Farhadi Kiadeh, Conor V. Dolan, Sara A. Paciga, Per Hoffmann, Leina Lu, Andrew M. McIntosh, Tim B. Bigdeli, Stephanie H. Witt, Matthew Traylor, Grant Sinnamon, Brien P. Riley, Roy H. Perlis, Patrick J. McGrath, Craig L. Hyde, Ling Shen, Na Cai, Yunpeng Wang, Evelin Mihailov, Isaac S. Kohane

Publikováno v: Wray, N R, Ripke, S, Mattheisen, M, Trzaskowski, M, Byrne, E M, Abdellaoui, A, Adams, M J, Agerbo, E, Air, T M, Andlauer, T M F, Bacanu, S-A, Bækvad-Hansen, M, Beekman, A F T, Bigdeli, T B, Binder, E B, Blackwood, D R H, Bryois, J, Buttenschøn, H N, Bybjerg-Grauholm, J, Cai, N, Castelao, E, Christensen, J H, Clarke, T-K, Coleman, J I R, Colodro-Conde, L, Couvy-Duchesne, B, Craddock, N, Crawford, G E, Crowley, C A, Dashti, H S, Davies, G, Deary, I J, Degenhardt, F, Derks, E M, Direk, N, Dolan, C V, Dunn, E C, Eley, T C, Eriksson, N, Escott-Price, V, Kiadeh, F H F, Finucane, H K, Forstner, A J, Frank, J, Hall, L S, MacIntyre, D J & Thomson, P A & Hayward, C & McIntosh, A M & Porteous, D J 2018, ' Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression ', Nature Genetics, vol. 50, no. 5, pp. 668-681 . https://doi.org/10.1038/s41588-018-0090-3
Wray, N R, Ripke, S, Mattheisen, M, Trzaskowski, M, Byrne, E M, Abdellaoui, A, Adams, M J, Agerbo, E, Air, T M, Andlauer, T M F, Bacanu, S-A, Bækvad-Hansen, M, Beekman, A F T, Bigdeli, T B, Binder, E B, Blackwood, D R H, Bryois, J, Buttenschøn, H N, Bybjerg-Grauholm, J, Cai, N, Castelao, E, Christensen, J H, Clarke, T-K, Coleman, J I R, Colodro-Conde, L, Couvy-Duchesne, B, Craddock, N, Crawford, G E, Crowley, C A, Dashti, H S, Davies, G, Deary, I J, Degenhardt, F, Derks, E M, Direk, N, Dolan, C V, Dunn, E C, Eley, T C, Eriksson, N, Escott-Price, V, Grove, J, Hansen, C S, Hansen, T F, Pedersen, C B, Pedersen, M G, Qvist, P, Yang, J, Mors, O, Mortensen, P B, Nordentoft, M, Werge, T, Børglum, A D & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium 2018, ' Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression ', Nature Genetics, vol. 50, no. 5, pp. 668-681 . https://doi.org/10.1038/s41588-018-0090-3
Nature Genetics
Wray, N R, Ripke, S, Mattheisen, M, Trzaskowski, M, Byrne, E M, Abdellaoui, A, Adams, M J, Agerbo, E, Air, T M, Andlauer, T M F, Bacanu, S A, Bækvad-Hansen, M, Beekman, A F T, Bigdeli, T B, Binder, E B, Blackwood, D R H, Bryois, J, Buttenschøn, H N, Bybjerg-Grauholm, J, Cai, N, Castelao, E, Christensen, J H, Clarke, T K, Coleman, J I R, Colodro-Conde, L, Couvy-Duchesne, B, Craddock, N, Crawford, G E, Crowley, C A, Dashti, H S, Davies, G, Deary, I J, Degenhardt, F, Derks, E M, DIrek, N, Dolan, C V, Dunn, E C, Eley, T C, Eriksson, N, Escott-Price, V, Kiadeh, F H F, Finucane, H K, Forstner, A J, Frank, J, Gaspar, H A, Gill, M, Giusti-Rodríguez, P, Goes, F S, Gordon, S D, Grove, J, Hall, L S, Hannon, E, Hansen, C S, Hansen, T F, Herms, S, Hickie, I B, Hoffmann, P, Homuth, G, Horn, C, Hottenga, J J, Hougaard, D M, Hu, M, Hyde, C L, Ising, M, Jansen, R, Jin, F, Jorgenson, E, Knowles, J A, Kohane, I S, Kraft, J, Kretzschmar, W W, Krogh, J, Kutalik, Z, Lane, J M, Li, Y, Li, Y, Lind, P A, Liu, X, Lu, L, MacIntyre, D J, MacKinnon, D F, Maier, R M, Maier, W, Marchini, J, Mbarek, H, McGrath, P, McGuffin, P, Medland, S E, Mehta, DI, Middeldorp, C M, Mihailov, E, Milaneschi, Y, Milani, L, Mill, J, Mondimore, F M, Montgomery, G W, Mostafavi, S, Mullins, N, Nauck, M, Ng, B, Nivard, M G, Nyholt, D R, O'Reilly, P F, Oskarsson, H, Owen, M J, Painter, J N, Pedersen, C B, Pedersen, M G, Peterson, R E, Pettersson, E, Peyrot, W J, Pistis, G, Posthuma, D, Purcell, S M, Quiroz, J A, Qvist, P, Rice, J P, Riley, B P, Rivera, M, Saeed Mirza, S, Saxena, R, Schoevers, R, Schulte, E C, Shen, L, Shi, J, Shyn, S I, Sigurdsson, E, Sinnamon, G B C, Smit, J H, Smith, D J, Stefansson, H, Steinberg, S, Stockmeier, C A, Streit, F, Strohmaier, J, Tansey, K E, Teismann, H, Teumer, A, Thompson, W, Thomson, P A, Thorgeirsson, T E, Tian, C, Traylor, M, Treutlein, J, Trubetskoy, V, Uitterlinden, A G, Umbricht, D, Van Der Auwera, S, Van Hemert, A M, Viktorin, A, Visscher, P M, Wang, Y, Webb, B T, Weinsheimer, S M, Wellmann, J, Willemsen, G, Witt, S H, Wu, Y, Xi, H S, Yang, J, Zhang, F, Arolt, V, Baune, B T, Berger, K, Boomsma, D I, Cichon, S, Dannlowski, U, De Geus, E C J, Depaulo, J R, Domenici, E, Domschke, K, Esko, T, Grabe, H J, Hamilton, S P, Hayward, C, Heath, A C, Hinds, D A, Kendler, K S, Kloiber, S, Lewis, G, Li, Q S, Lucae, S, Madden, P F A, Magnusson, P K, Martin, N G, McIntosh, A M, Metspalu, A, Mors, O, Mortensen, P B, Müller-Myhsok, B, Nordentoft, M, Nöthen, M M, O'Donovan, M C, Paciga, S A, Pedersen, N L, Penninx, B W J H, Perlis, R H, Porteous, D J, Potash, J B, Preisig, M, Rietschel, M, Schaefer, C, Schulze, T G, Smoller, J W, Stefansson, K, Tiemeier, H, Uher, R, Völzke, H, Weissman, M M, Werge, T, Winslow, A R, Lewis, C M, Levinson, D F, Breen, G, Børglum, A D & Sullivan, P F 2018, ' Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression ', Nature Genetics, vol. 50, no. 5, pp. 668-681 . https://doi.org/10.1038/s41588-018-0090-3
Nature genetics 50(5), 668-681 (2018). doi:10.1038/s41588-018-0090-3
NATURE GENETICS
Wray, N R, Ripke, S, Mattheisen, M, Trzaskowski, M, Byrne, E M, Abdellaoui, A, Adams, M J, Agerbo, E, Air, T M, Andlauer, T M F, Bacanu, S A, Bækvad-Hansen, M, Beekman, A F T, Bigdeli, T B, Binder, E B, Blackwood, D R H, Bryois, J, Buttenschøn, H N, Bybjerg-Grauholm, J, Cai, N, Castelao, E, Christensen, J H, Clarke, T K, Coleman, J I R, Colodro-Conde, L, Couvy-Duchesne, B, Craddock, N, Crawford, G E, Crowley, C A, Dashti, H S, Davies, G, Deary, I J, Degenhardt, F, Derks, E M, DIrek, N, Dolan, C V, Dunn, E C, Eley, T C, Eriksson, N, Hottenga, J J, Jansen, R, Mbarek, H, Middeldorp, C M, Milaneschi, Y, Nivard, M G, Posthuma, D, Smit, J H, Willemsen, G, Boomsma, D I & Penninx, B W J H 2018, ' Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression ', Nature Genetics, vol. 50, no. 5, pp. 668-681 . https://doi.org/10.1038/s41588-018-0090-3
Nature genetics, 50(5), 668-681. Nature Publishing Group
Wray, N R, Ripke, S, Mattheisen, M, Trzaskowski, M, Byrne, E M, Abdellaoui, A, Adams, M J, Agerbo, E, Air, T M, Andlauer, T M F, Bacanu, S-A, Bækvad-Hansen, M, Beekman, A F T, Bigdeli, T B, Binder, E B, Blackwood, D R H, Bryois, J, Buttenschøn, H N, Bybjerg-Grauholm, J, Cai, N, Castelao, E, Christensen, J H, Clarke, T, Coleman, J I R, Colodro-Conde, L, Couvy-Duchesne, B, Craddock, N, Crawford, G E, Crowley, C A, Dashti, H S, Davies, G, Deary, I J, Degenhardt, F, Derks, E M, Direk, N, Eley, T C, Gaspar, H A, Hansen, T F, Li, Y, Mcguffin, P, Mill, J, Mullins, N, Purcell, S M, Riley, B P, Smith, D J, Tansey, K E, Traylor, M, Uher, R, Lewis, C M & Breen, G & O'Reilly, P F 2018, ' Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression ', Nature Genetics, vol. 50, no. 5, pp. 668-681 . https://doi.org/10.1038/s41588-018-0090-3
Nature Genetics, 50(5), 668-681. Nature Publishing Group
Nature Genetics, 50(5), 668-+. Nature Publishing Group
Nature Genetics, 50(5), 668
Nature genetics
Nature genetics, vol. 50, no. 5, pp. 668-681

Major depressive disorder (MDD) is a common illness accompanied by considerable morbidity, mortality, costs, and heightened\ud risk of suicide. We conducted a genome-wide association meta-analysis based in 135,458 cases and 344,901 controls and ident

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https://hdl.handle.net/1871.1/622c22a4-86de-4ad8-a6de-69e83c983e4c