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Akademický článek

Urinary prostanoids are elevated by anti-TNF and anti-IL6 receptor disease-modifying antirheumatic drugs but are not predictive of response to treatment in early rheumatoid arthritis

Autor: Jianyang Liu, Helena Idborg, Marina Korotkova, Kristina Lend, Ronald van Vollenhoven, Jon Lampa, Anna Rudin, Dan Nordström, Bjorn Gudbjornsson, Gerdur Gröndal, Till Uhlig, Kim Hørslev-Petersen, Merete Lund Hetland, Mikkel Østergaard, Michael Nurmohamed, Per-Johan Jakobsson

Publikováno v: Arthritis Research & Therapy, Vol 26, Iss 1, Pp 1-9 (2024)

Abstract Background Disease-modifying antirheumatic drugs (DMARDs) are widely used for treating rheumatoid arthritis (RA). However, there are no established biomarkers to predict a patient’s response to these therapies. Prostanoids, encompassing pr

Externí odkaz: https://doaj.org/article/2260d524aa2942c78c1315d2c24d7266

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Akademický článek

Obesity is a risk factor for poor response to treatment in early rheumatoid arthritis: a NORD-STAR study

Publikováno v: RMD Open, Vol 10, Iss 2 (2024)

Objective This report from the NORD-STAR (Nordic Rheumatic Diseases Strategy Trials and Registries) trial aimed to determine if obesity is associated with response to conventional and biological antirheumatic treatment in early rheumatoid arthritis (

Externí odkaz: https://doaj.org/article/6b01938d1e354a908fc7fc126fb8f00b

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Akademický článek

Performance of the Rheumatoid Arthritis Impact of Disease (RAID) score in relation to flares in disease activity

Publikováno v: RMD Open, Vol 10, Iss 1 (2024)

Objectives To explore the performance of the EULAR-initiated patient-reported Rheumatoid Arthritis Impact of Disease (RAID) questionnaire in relation to flares in disease activity, including comparison with other disease activity outcomes.Methods Pat

Externí odkaz: https://doaj.org/article/a194135dbac9473892ac348f607099d8

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Akademický článek

Lifestyle factors predict gout outcomes: Results from the NOR-Gout longitudinal 2-year treat-to-target study

Autor: Tore K Kvien, Joseph Sexton, Till Uhlig, Espen A Haavardsholm, Hilde Berner Hammer, Lars Fridtjof Karoliussen

Publikováno v: RMD Open, Vol 9, Iss 4 (2023)

Objective Gout is associated with lifestyle, body mass index (BMI) and comorbidities, including dyslipidaemia. We studied how in actively treated patients, anthropometric measures and lipid levels changed over 2 years and whether they predicted gout

Externí odkaz: https://doaj.org/article/9fd7a6ef83ed4a78921bb8533f6754ea

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Akademický článek

One- and 2-year flare rates after treat-to-target and tight-control therapy of gout: results from the NOR-Gout study

Autor: Till Uhlig, Lars F. Karoliussen, Joe Sexton, Tore K. Kvien, Espen A. Haavardsholm, Fernando Perez-Ruiz, Hilde Berner Hammer

Publikováno v: Arthritis Research & Therapy, Vol 24, Iss 1, Pp 1-11 (2022)

Abstract Objectives To explore the frequency and predictors of flares over 2 years during a treat-to-target strategy with urate-lowering therapy (ULT) in patients with gout. Methods In the treat-to-target, tight control NOR-Gout study patients starte

Externí odkaz: https://doaj.org/article/1a5f87e14d14442b91f730f8873962a7

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Akademický článek

Plasma interferon-alpha is associated with double-positivity for autoantibodies but is not a predictor of remission in early rheumatoid arthritis—a spin-off study of the NORD-STAR randomized clinical trial

Autor: Marit Stockfelt, Anna-Carin Lundell, Merete Lund Hetland, Mikkel Østergaard, Till Uhlig, Marte Schrumpf Heiberg, Espen A. Haavardsholm, Michael T. Nurmohamed, Jon Lampa, Dan Nordström, Kim Hørslev Petersen, Bjorn Gudbjornsson, Gerdur Gröndal, Jonathan Aldridge, Kerstin Andersson, Kaj Blennow, Henrik Zetterberg, Ronald van Vollenhoven, Anna Rudin

Publikováno v: Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-11 (2021)

Abstract Background The type I interferon (IFN) gene signature is present in a subgroup of patients with early rheumatoid arthritis (RA). Protein levels of IFNα have not been measured in RA and it is unknown whether they associate with clinical char

Externí odkaz: https://doaj.org/article/97aea0fe054f4787bcafae939a4fcc43

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Akademický článek

Validity and diagnostic performance of fluorescence optical imaging measuring synovitis in hand osteoarthritis: baseline results from the Nor-Hand cohort

Autor: Øystein Maugesten, Alexander Mathiessen, Hilde Berner Hammer, Sigrid Valen Hestetun, Tore Kristian Kvien, Till Uhlig, Sarah Ohrndorf, Ida Kristin Haugen

Publikováno v: Arthritis Research & Therapy, Vol 22, Iss 1, Pp 1-9 (2020)

Abstract Objective Fluorescence optical imaging (FOI) demonstrates enhanced microcirculation in finger joints as a sign of inflammation. We wanted to assess the validity and diagnostic performance of FOI measuring synovitis in persons with hand OA, c

Externí odkaz: https://doaj.org/article/0aab81a9600444c78c11f83daf28826f

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Akademický článek

12-month results from the real-life observational treat-to-target and tight-control therapy NOR-Gout study: achievements of the urate target levels and predictors of obtaining this target

Autor: Tore K Kvien, Joseph Sexton, Till Uhlig, Espen A Haavardsholm, Hilde Berner Hammer, Lars F Karoliussen

Publikováno v: RMD Open, Vol 7, Iss 1 (2021)

Objectives Gout is often not adequately treated, and we aimed to apply urate lowering treatment (ULT) combined with individual information to achieve target serum urate (sUA) in clinical practice, and to identify predictors of achievement of this sUA

Externí odkaz: https://doaj.org/article/03124d20a9cb4ec5bd839ecccf7dc00d

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