A Novel Copper(II) Indenoisoquinoline Complex Inhibits Topoisomerase I, Induces G2 Phase Arrest, and Autophagy in Three Adenocarcinomas

Autor: Caroline Molinaro, Nathalie Wambang, Till Bousquet, Anne-Sophie Vercoutter-Edouart, Lydie Pélinski, Katia Cailliau, Alain Martoriati

Publikováno v: Frontiers in Oncology, Vol 12 (2022)

Topoisomerases, targets of inhibitors used in chemotherapy, induce DNA breaks accumulation leading to cancer cell death. A newly synthesized copper(II) indenoisoquinoline complex WN197 exhibits a cytotoxic effect below 0.5 µM, on MDA-MB-231, HeLa, a

Externí odkaz: https://doaj.org/article/bc1f449418844aa3b2776757d324a9b4

Visible-Light-Driven CarboxyLic Amine Protocol (CLAP) for the Synthesis of 2-Substituted Piperazines under Batch and Flow Conditions

Autor: Antony Bigot, Till Bousquet, Mathieu Sauthier, Robin Gueret, Lydie Pelinski, Vincent Ferey

Publikováno v: Organic Letters. 22:5157-5162

Piperazines are privileged scaffolds in medicinal chemistry. Disclosed herein is a visible-light-promoted decarboxylative annulation protocol between a glycine-based diamine and various aldehydes to access 2-aryl, 2-heteroaryl, as well as 2-alkyl pip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c687be4b0dae43731fdec98e4f32517
https://doi.org/10.1021/acs.orglett.0c01759

One-Pot Synthesis of 2,5-Disubstituted Furans through In Situ Formation of Allenes and Enolization Cascade

Autor: Sylvain Pellegrini, Till Bousquet, Yann Bernhard, Audrey Favrelle-Huret, Philippe Zinck, Lydie Pelinski, Joachim Gilbert

Publikováno v: European Journal of Organic Chemistry. 2019:7870-7873

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c8decd7d14f5afc88fb3f8f671bc70b4
https://doi.org/10.1002/ejoc.201901669

Photocatalyzed Amidoarylation of 1,3‐Butadiene

Autor: Mathieu Sauthier, Cyrille Gosset, Lydie Pelinski, Sylvain Pellegrini, Till Bousquet, Clément Dumont, Aurélien Moncomble

Publikováno v: Advanced Synthesis and Catalysis
Advanced Synthesis and Catalysis, Wiley-VCH Verlag, 2020, 362 (15), pp.3100-3104. ⟨10.1002/adsc.202000071⟩
Advanced Synthesis and Catalysis, 2020, 362 (15), pp.3100-3104. ⟨10.1002/adsc.202000071⟩

International audience

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e26233694d99440886b4cbb2ddae651
https://hal.archives-ouvertes.fr/hal-02963037

Effects of Ferrocenyl 4-(Imino)-1,4-Dihydro-quinolines on

Autor: Guillaume, Marchand, Nathalie, Wambang, Sylvain, Pellegrini, Caroline, Molinaro, Alain, Martoriati, Till, Bousquet, Angel, Markey, Arlette, Lescuyer-Rousseau, Jean-François, Bodart, Katia, Cailliau, Lydie, Pelinski, Matthieu, Marin

Publikováno v: International Journal of Molecular Sciences

Xenopus oocytes were used as cellular and molecular sentinels to assess the effects of a new class of organometallic compounds called ferrocenyl dihydroquinolines that have been developed as potential anti-cancer agents. One ferrocenyl dihydroquinoli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c7ae3a468a8344719ac9d5e2450056c1
https://pubmed.ncbi.nlm.nih.gov/32357477