Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Till, Böcking"'
Autor:
KM Rifat Faysal, James C Walsh, Nadine Renner, Chantal L Márquez, Vaibhav B Shah, Andrew J Tuckwell, Michelle P Christie, Michael W Parker, Stuart G Turville, Greg J Towers, Leo C James, David A Jacques, Till Böcking
Publikováno v:
eLife, Vol 13 (2024)
The HIV-1 capsid has emerged as a tractable target for antiretroviral therapy. Lenacapavir, developed by Gilead Sciences, is the first capsid-targeting drug approved for medical use. Here, we investigate the effect of lenacapavir on HIV capsid stabil
Externí odkaz:
https://doaj.org/article/08ba42401fe84baebde255dedc84b832
Publikováno v:
Bio-Protocol, Vol 12, Iss 20 (2022)
The human immunodeficiency virus 1 (HIV-1) consists of a viral membrane surrounding the conical capsid. The capsid is a protein container assembled from approximately 1,500 copies of the viral capsid protein (CA), functioning as a reaction and transp
Externí odkaz:
https://doaj.org/article/b3d1e0eb74f340658a880f7bd0136594
Autor:
Conall McGuinness, James C Walsh, Charles Bayly-Jones, Michelle A Dunstone, Michelle P Christie, Craig J Morton, Michael W Parker, Till Böcking
Publikováno v:
eLife, Vol 11 (2022)
The cholesterol-dependent cytolysin perfringolysin O (PFO) is secreted by Clostridium perfringens as a bacterial virulence factor able to form giant ring-shaped pores that perforate and ultimately lyse mammalian cell membranes. To resolve the kinetic
Externí odkaz:
https://doaj.org/article/9c52c20469604be898a9fcf4065fd2d3
Autor:
Wang Peng, Jiong Shi, Chantal L. Márquez, Derrick Lau, James Walsh, K. M. Rifat Faysal, Chang H. Byeon, In-Ja L. Byeon, Christopher Aiken, Till Böcking
Publikováno v:
Retrovirology, Vol 16, Iss 1, Pp 1-13 (2019)
Abstract Background Efficient HIV-1 replication depends on interaction of the viral capsid with the host protein cyclophilin A (CypA). CypA, a peptidylprolyl isomerase, binds to an exposed loop in the viral CA protein via the enzyme’s active site.
Externí odkaz:
https://doaj.org/article/6e120061b0eb46949ed85b6c5045e5af
Autor:
Nadine Renner, Donna L Mallery, K M Rifat Faysal, Wang Peng, David A Jacques, Till Böcking, Leo C James
Publikováno v:
PLoS Pathogens, Vol 17, Iss 2, p e1009164 (2021)
The HIV capsid self-assembles a protective conical shell that simultaneously prevents host sensing whilst permitting the import of nucleotides to drive DNA synthesis. This is accomplished through the construction of dynamic, highly charged pores at t
Externí odkaz:
https://doaj.org/article/a8eba9633dfb4fecbe34fc3f141ac79b
Autor:
Nadine Renner, Alex Kleinpeter, Donna L. Mallery, Anna Albecka, K. M. Rifat Faysal, Till Böcking, Adolfo Saiardi, Eric O. Freed, Leo C. James
Publikováno v:
Nature Structural & Molecular Biology. 30:370-382
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d42fd8bd2df0345d558c9ce4d2ad8d0
https://doi.org/10.1038/s41594-022-00887-4
https://doi.org/10.1038/s41594-022-00887-4
Autor:
Donna L. Mallery, K.M. Rifat Faysal, Alex Kleinpeter, Miranda S.C. Wilson, Marina Vaysburd, Adam J. Fletcher, Mariia Novikova, Till Böcking, Eric O. Freed, Adolfo Saiardi, Leo C. James
Publikováno v:
Cell Reports, Vol 29, Iss 12, Pp 3983-3996.e4 (2019)
Summary: HIV-1 hijacks host proteins to promote infection. Here we show that HIV is also dependent upon the host metabolite inositol hexakisphosphate (IP6) for viral production and primary cell replication. HIV-1 recruits IP6 into virions using two l
Externí odkaz:
https://doaj.org/article/a52365df0e4b4bc7a7ef2dece3f93e77
Autor:
Yasmin M. Ramdzan, Mikhail M. Trubetskov, Angelique R. Ormsby, Estella A. Newcombe, Xiaojing Sui, Mark J. Tobin, Marie N. Bongiovanni, Sally L. Gras, Grant Dewson, Jason M.L. Miller, Steven Finkbeiner, Nagaraj S. Moily, Jonathan Niclis, Clare L. Parish, Anthony W. Purcell, Michael J. Baker, Jacqueline A. Wilce, Saboora Waris, Diana Stojanovski, Till Böcking, Ching-Seng Ang, David B. Ascher, Gavin E. Reid, Danny M. Hatters
Publikováno v:
Cell Reports, Vol 19, Iss 5, Pp 919-927 (2017)
Summary: Competing models exist in the literature for the relationship between mutant Huntingtin exon 1 (Httex1) inclusion formation and toxicity. In one, inclusions are adaptive by sequestering the proteotoxicity of soluble Httex1. In the other, inc
Externí odkaz:
https://doaj.org/article/a88e3936e1a84e4ebc9bd6f66ea0df8a
Autor:
Bronte A. Johnstone, Riya Joseph, Michelle P. Christie, Craig J. Morton, Conall McGuiness, James C. Walsh, Till Böcking, Rodney K. Tweten, Michael W. Parker
Publikováno v:
IUBMB Life. 74:1169-1179
The cholesterol-dependent cytolysins (CDCs) are a major family of bacterial pore-forming proteins secreted as virulence factors by Gram-positive bacterial species. CDCs are produced as soluble, monomeric proteins that bind specifically to cholesterol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b139d738d4fd5f1257f096aba544651
https://doi.org/10.1002/iub.2661
https://doi.org/10.1002/iub.2661
Autor:
Chantal Márquez, Derrick Lau, James Walsh, K. M. Rifat Faysal, Michael Parker, Stuart Turville, Till Böcking
Publikováno v:
Bio-Protocol, Vol 9, Iss 13 (2019)
The stability of the HIV-1 capsid and the spatiotemporal control of its disassembly, a process called uncoating, need to be finely tuned for infection to proceed. Biochemical methods for measuring capsid lattice disassembly in bulk are unable to reso
Externí odkaz:
https://doaj.org/article/ba49d8a7f4ef4859be5d0a8f937726e3