Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Till, Adhikary"'
Autor:
Laura Zein, Josina Grossmann, Helena Swoboda, Christina Borgel, Bernhard Wilke, Stephan Awe, Andrea Nist, Thorsten Stiewe, Oliver Stehling, Sven-Andreas Freibert, Till Adhikary, Ho-Ryun Chung
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
It has remained yet unclear which soluble factors regulate the anti-inflammatory macrophage phenotype observed in both homeostasis and tumourigenesis. We show here that haptoglobin, a major serum protein with elusive immunoregulatory properties, bind
Externí odkaz:
https://doaj.org/article/507e4731fed9448d9eeb658de17cc758
Autor:
Tim L. Czech, Philipp P. Nelson, Clemens Thölken, Patrick Meyer, Timo Hess, Ho-Ryun Chung, Till Adhikary
Publikováno v:
HardwareX, Vol 18, Iss , Pp e00517- (2024)
The advent of single cell technologies resulted in growing demand for microfluidics in the biological sciences. Commercial platforms have remained expensive, inflexible, and non-customizable black boxes. We developed an open source, multichannel, zer
Externí odkaz:
https://doaj.org/article/8918af144b1745a2a567a6e281c334b0
Autor:
Reem Alkhayer, Viviane Ponath, Miriam Frech, Till Adhikary, Johannes Graumann, Andreas Neubauer, Elke Pogge von Strandmann
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-14 (2023)
Abstract The immunoreceptor NKG2D, which is expressed on NK cells and T cell subsets is critically involved in tumor immune surveillance. This applies in particular to acute myeloid leukemia (AML), which evades immune detection by downregulation of N
Externí odkaz:
https://doaj.org/article/dc6b4274aced429fa28f5022f9dff929
Autor:
Maik Luu, Sabine Pautz, Vanessa Kohl, Rajeev Singh, Rossana Romero, Sébastien Lucas, Jörg Hofmann, Hartmann Raifer, Niyati Vachharajani, Lucia Campos Carrascosa, Boris Lamp, Andrea Nist, Thorsten Stiewe, Yoav Shaul, Till Adhikary, Mario M. Zaiss, Matthias Lauth, Ulrich Steinhoff, Alexander Visekruna
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Short-chain fatty acids (SCFAs) have immunomodulatory effects, but the underlying mechanisms are still unclear. Here the authors show that a SCFA, pentanoate, suppresses autoimmune inflammation in mouse models of colitis and multiple sclerosis via ep
Externí odkaz:
https://doaj.org/article/d856e522710041fdbeadd9b5689c49a8
Autor:
Axel Weber, Sigrid C. Schwarz, Jörg Tost, Dietrich Trümbach, Pia Winter, Florence Busato, Pawel Tacik, Anita C. Windhorst, Maud Fagny, Thomas Arzberger, Catriona McLean, John C. van Swieten, Johannes Schwarz, Daniela Vogt Weisenhorn, Wolfgang Wurst, Till Adhikary, Dennis W. Dickson, Günter U. Höglinger, Ulrich Müller
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Progressive supranuclear palsy (PSP) is a neurodegenerative disease characterized by aggregation of Tau, encoded by MAPT. Here, the authors perform an EWAS for PSP in prefrontal lobe tissue and find hypermethylation of DLX1 and its antisense transcri
Externí odkaz:
https://doaj.org/article/ec0d1bbe28a5442e9f538934be3dd2f3
Autor:
Anke Koeniger, Pierfrancesco Polo, Anna Brichkina, Florian Finkernagel, Alexander Visekruna, Andrea Nist, Thorsten Stiewe, Michael Daude, Wibke E Diederich, Thomas M Gress, Till Adhikary, Matthias Lauth
Publikováno v:
NAR Cancer. 5
Transcriptional cancer subtypes which correlate with traits such as tumor growth, drug sensitivity or the chances of relapse and metastasis, have been described for several malignancies. The core regulatory circuits (CRCs) defining these subtypes are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15b6c374e0f519b67e877abd3f4af891
https://doi.org/10.1093/narcan/zcad007
https://doi.org/10.1093/narcan/zcad007
Autor:
Annika Unger, Florian Finkernagel, Nathalie Hoffmann, Felix Neuhaus, Barbara Joos, Andrea Nist, Thorsten Stiewe, Alexander Visekruna, Uwe Wagner, Silke Reinartz, Sabine Müller-Brüsselbach, Rolf Müller, Till Adhikary
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Tumors frequently exploit homeostatic mechanisms that suppress expression of IL-12, a central mediator of inflammatory and anti-tumor responses. The p40 subunit of the IL-12 heterodimer, encoded by IL12B, is limiting for these functions. Ovarian carc
Externí odkaz:
https://doaj.org/article/239c44ab89994bb895b66326f8dd05ca
Autor:
Laura Zein, Josina Grossmann, Helena Swoboda, Christina Borgel, Bernhard Wilke, Stephan Awe, Andrea Nist, Thorsten Stiewe, Oliver Stehling, Sven-Andreas Freibert, Till Adhikary, Ho-Ryun Chung
Haptoglobin is the major detoxifier of hemoglobin. Moreover, haptoglobin modulates the inflammatory responseviaNFκB. In some studies haptoglobin represses and in others it activates NFκB. We show here that these conflicting results are explainable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69dc39b05cc522ee670ea227f6a8cd4e
https://doi.org/10.1101/2022.11.22.516855
https://doi.org/10.1101/2022.11.22.516855
Autor:
Aleksandra Lopez Krol, Hannah P Nehring, Felix F Krause, Anne Wempe, Hartmann Raifer, Andrea Nist, Thorsten Stiewe, Wilhelm Bertrams, Bernd Schmeck, Maik Luu, Hanna Leister, Ho‐Ryun Chung, Uta‐Maria Bauer, Till Adhikary, Alexander Visekruna
Publikováno v:
EMBO reports. 23
Increased lactate levels in the tissue microenvironment are a well-known feature of chronic inflammation. However, the role of lactate in regulating T cell function remains controversial. Here, we demonstrate that extracellular lactate predominantly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a049f76bbaed8cb91cd9740cbed78366
https://doi.org/10.15252/embr.202254685
https://doi.org/10.15252/embr.202254685
Activation of Cilia-Independent Hedgehog/GLI1 Signaling as a Novel Concept for Neuroblastoma Therapy
Autor:
Iris Nee, Ilya Galperin, Thorsten Stiewe, Matthias Lauth, Anke Koeniger, Lukas Dempwolff, Till Adhikary, Anna Brichkina, Wibke E. Diederich, Anna Hupfer, Andrea Nist, Florian Finkernagel
Publikováno v:
Cancers
Volume 13
Issue 8
Cancers, Vol 13, Iss 1908, p 1908 (2021)
Volume 13
Issue 8
Cancers, Vol 13, Iss 1908, p 1908 (2021)
Simple Summary Elevated GLI1 expression levels are associated with improved survival in NB patients and GLI1 overexpression exerts tumor-suppressive traits in cultured NB cells. However, NB cells are protected from increased GLI1 levels as they have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54386398a04600064f01f40cccc0df47