Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Tilanthi M Jayawardena"'
Autor:
Tilanthi M. Jayawardena, Conrad P. Hodgkinson, Elizabeth A. Finch, Maria Mirotsou, Victor J. Dzau, Richard E. Pratt, Hengtao Zhang, Paul B. Rosenberg, Lunan Zhang
Publikováno v:
Circulation Research. 116:418-424
Rationale : A major goal for the treatment of heart tissue damaged by cardiac injury is to develop strategies for restoring healthy heart muscle through the regeneration and repair of damaged myocardium. We recently demonstrated that administration o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20940808dd9082bfa5e261571049b96e
https://doi.org/10.1161/circresaha.116.304510
https://doi.org/10.1161/circresaha.116.304510
Autor:
Maria Mirotsou, Victor J. Dzau, Nenad Bursac, Yanzhen Li, Tilanthi M. Jayawardena, Conrad P. Hodgkinson, Sophie Dal-Pra
Publikováno v:
Scientific Reports
We have recently shown that a combination of microRNAs, miR combo, can directly reprogram cardiac fibroblasts into functional cardiomyocytes in vitro and in vivo. Reprogramming of cardiac fibroblasts by miR combo in vivo is associated with improved c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10224f8299e4470bf5440ad4f353f040
https://doi.org/10.1038/srep38815
https://doi.org/10.1038/srep38815
Publikováno v:
Methods in Molecular Biology ISBN: 9781493905119
The therapeutic administration of microRNAs represents an innovative reprogramming strategy with which to advance cardiac regeneration and personalized medicine. Recently, a distinct set of microRNAs was found capable of converting murine fibroblasts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23a8416b946261c3ae5f4680522a1d4d
https://doi.org/10.1007/978-1-4939-0512-6_18
https://doi.org/10.1007/978-1-4939-0512-6_18
Abstract 141: Histone Methyltransferase Setdb2 is important for miRNA mediated cardiac reprogramming
Publikováno v:
Circulation Research. 113
Rationale: Regeneration of damaged cardiac tissue after injury presents a daunting challenge in cardiovascular medicine. Recent developments in reprogramming of somatic cells directly to cells of other lineages have raised the possibility of using th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1c5ea3c41644e997bc3f3aa5386c6c1
https://doi.org/10.1161/res.113.suppl_1.a141
https://doi.org/10.1161/res.113.suppl_1.a141
MicroRNA-mediated in vitro and in vivo direct reprogramming of cardiac fibroblasts to cardiomyocytes
Autor:
J. Alan Payne, Kumar Pandya, Bakytbek Egemnazarov, Paul B. Rosenberg, Lunan Zhang, Elizabeth A. Finch, Maria Mirotsou, Victor J. Dzau, Zhiping Zhang, Tilanthi M. Jayawardena
Publikováno v:
Circulation research. 110(11)
Rationale: Repopulation of the injured heart with new, functional cardiomyocytes remains a daunting challenge for cardiac regenerative medicine. An ideal therapeutic approach would involve an effective method at achieving direct conversion of injured
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::795091272689babbe404847b52764fd4
https://pubmed.ncbi.nlm.nih.gov/22628569
https://pubmed.ncbi.nlm.nih.gov/22628569
Autor:
Maria Mirotsou, Victor J. Dzau, Tilanthi M. Jayawardena, Jeffrey Schmeckpeper, Massimiliano Gnecchi
Stem cells play an important role in restoring cardiac function in the damaged heart. In order to mediate repair, stem cells need to replace injured tissue by differentiating into specialized cardiac cell lineages and/or manipulating the cell and mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5f7b33ee3b619971ede8f3f1b033d36
https://europepmc.org/articles/PMC3021634/
https://europepmc.org/articles/PMC3021634/
Autor:
Hiroshi Uejima, Tilanthi M. Jayawardena, Karl W. Broman, Andrew P. Feinberg, Daniel A. Haber, Jason D. Ravenel, Elizabeth J. Perlman, Daphne W. Bell, Emily L. Niemitz
Publikováno v:
Journal of the National Cancer Institute. 93(22)
Background: Loss of imprinting (LOI) of the insulin-like growth factor-II (IGF2) gene, an epigenetic alteration associated with expression of the normally silent maternal allele, was observed first in Wilms tumor. Although LOI has subsequently been d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6858496fc9aa4dbb6140f1e861001bc
https://pubmed.ncbi.nlm.nih.gov/12464656
https://pubmed.ncbi.nlm.nih.gov/12464656