Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Tikva Carrick"'
Autor:
Alexander Greenfield, Tikva Carrick, John A. Butera, Dianne Kowal, John Dunlop, Brian Jow, Cristina Grosanu, Qiang Lu, Beal McIlvain, John P. Williams
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:4985-4988
Excitatory amino acid transporters (EAATs) play a pivotal role in maintaining glutamate homeostasis in the mammalian central nervous system, with the EAAT-2 subtype thought to be responsible for the bulk of the glutamate uptake in forebrain regions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c5a1dd7bbb3e90347e18220f7cf664f
https://doi.org/10.1016/j.bmcl.2005.08.003
https://doi.org/10.1016/j.bmcl.2005.08.003
Autor:
John Dunlop, Dianne Kowal, Scott Eliasof, Tikva Carrick, Alexander Greenfield, Robert E. Petroski, H. Beal McIlvain, Gary Paul Stack
Publikováno v:
British Journal of Pharmacology. 140:839-846
The pharmacological profile of a novel glutamate transport inhibitor, WAY-855 (3-amino-tricyclo[2.2.1.02.6]heptane-1,3-dicarboxylic acid), on the activity of the human forebrain glutamate transporters EAAT1, EAAT2 and EAAT3 expressed in stable mammal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::054d06861d1364d0bb5256cf89f66a60
https://doi.org/10.1038/sj.bjp.0705509
https://doi.org/10.1038/sj.bjp.0705509
Autor:
Jean Zhang, Ping Zhou, Tikva Carrick, Albert J. Robichaud, Rolf Feenstra, Jan-Hendrik Reinders, Dianne Kowal, Chris G. Kruse, Martina A.W. van der Neut, Yinfa Yan, David P. Rotella, Mark H. Pausch, Margaret Lai, Karen L. Marquis
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(9)
A dihydroquinolinone moiety was found to be a potent serotonin reuptake inhibitor pharmacophore when combined with certain amines. This fragment was coupled with selected D2 ligands to prepare a series of dual acting compounds with attractive in vitr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5166982a958128acf3a0153c1b0e0b45
https://pubmed.ncbi.nlm.nih.gov/20347298
https://pubmed.ncbi.nlm.nih.gov/20347298
Autor:
Jean Zhang, Julie A. Brennan, Chris G. Kruse, Jan-Hendrik Reinders, Dianne Kowal, Geraldine Ruth Mcfarlane, Feenstra Roelof W, Sara Núñez-García, Andrew C. McCreary, Karen L. Marquis, Radka Graf, Mark H. Pausch, Alexander Greenfield, Margaret Lai, Albert J. Robichaud, Farhana Pruthi, Tikva Carrick, David P. Rotella, Cristina Grosanu, Steven M. Grauer, Rajiah A. Denny, Kelly Sullivan, Rachel Navarra, Martina A.W. van der Neut
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(19)
A 5-fluoro-tetrahydrocarbazole serotonin reuptake inhibitor (SRI) building block was combined with a variety of linkers and dopamine D2 receptor ligands in an attempt to identify potent D2 partial agonist/SRI molecules for treatment of schizophrenia.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d888ee9ef744cb0b6c28720c1c17096
https://pubmed.ncbi.nlm.nih.gov/19720528
https://pubmed.ncbi.nlm.nih.gov/19720528
Autor:
Tikva Carrick, Julia N. Heinrich, John A. Butera, Karen L. Marquis, Scott Christian Mayer, Eugene Tseng, Tim Lock, Shaiu-Ching Sun, Albert J. Uveges, Dianne Kowal, Angela Kramer, Mark H. Pausch, Michael Popiolek
Publikováno v:
European journal of pharmacology. 605(1-3)
In functional assay assessments using the five muscarinic receptor subtypes, a second generation of muscarinic M(1)-preferring receptor agonists [AC-42 (1), AC-260584 (2), 77-LH-28-1 (3) and LY-593039 (4)] was shown to have higher selectivity for mus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8a59fa7176de756016d317f1bb22c51
https://pubmed.ncbi.nlm.nih.gov/19168056
https://pubmed.ncbi.nlm.nih.gov/19168056
Publikováno v:
Analytical biochemistry. 381(1)
We describe the first validated scintillation proximity assay (SPA) binding method for quantitation of 3 H-labeled d-lysergic acid diethylamide (LSD) binding to recombinant human 5-hydroxytryptamine 6 (5-HT 6 ) receptors expressed in Chinese hamster
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::597b89a5c245c4738795ba11724f4e77
https://pubmed.ncbi.nlm.nih.gov/18601889
https://pubmed.ncbi.nlm.nih.gov/18601889
Autor:
Dianne Kowal, Cristina Grosanu, Stephen Lin, Robert E. Petroski, Brian Jow, John Dunlop, John A. Butera, Tikva Carrick, Alexander Greenfield, Alan C. Foster, John A. Williams, Beal McIlvain, Kristi Fan, Qiang Lu
Publikováno v:
Molecular pharmacology. 68(4)
In this study, we describe the pharmacological characterization of novel aryl-ether, biaryl, and fluorene aspartic acid and diaminopropionic acid analogs as potent inhibitors of EAAT2, the predominant glutamate transporter in forebrain regions. The r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::620dcbabe015ca0a8a07c8907e673c38
https://pubmed.ncbi.nlm.nih.gov/16014807
https://pubmed.ncbi.nlm.nih.gov/16014807
Autor:
Dunlop, John1 Dunlopj@ wyeth.com, Eliasof, Scott2, Stack, Gary3, Mcllvain, H. Beal1, Greenfield, Alexander3, Kowal, Dianne1, Petroski, Robert2, Carrick, Tikva1
Publikováno v:
British Journal of Pharmacology. Nov2003, Vol. 140 Issue 5, p839-846. 8p. 1 Diagram, 8 Graphs.