Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Tijana Mitić"'
Autor:
Hywel Dunn-Davies, Tatiana Dudnakova, Antonella Nogara, Julie Rodor, Anita C. Thomas, Elisa Parish, Philippe Gautier, Alison Meynert, Igor Ulitsky, Paolo Madeddu, Andrea Caporali, Andrew Baker, David Tollervey, Tijana Mitić
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 2, Pp 102173- (2024)
Epigenetic processes involving long non-coding RNAs regulate endothelial gene expression. However, the underlying regulatory mechanisms causing endothelial dysfunction remain to be elucidated. Enhancer of zeste homolog 2 (EZH2) is an important rheost
Externí odkaz:
https://doaj.org/article/d40513abc2f7404891653803cdf55bcc
Publikováno v:
Non-Coding RNA, Vol 7, Iss 4, p 62 (2021)
The vascular endothelium comprises the interface between the circulation and the vessel wall and, as such, is under the dynamic regulation of vascular signalling, nutrients, and hypoxia. Understanding the molecular drivers behind endothelial cell (EC
Externí odkaz:
https://doaj.org/article/f46c44d17d724f54b377bebbfe7da00e
Autor:
Tijana Mitić, Andrea Caporali
Publikováno v:
Mitić, T & Caporali, A 2023, ' Emerging roles of non-coding RNAs in endothelial cell function ', Current opinion in physiology, pp. 100672 . https://doi.org/10.1016/j.cophys.2023.100672
Nearly 98% of the human genome is transcriptionally active but does not encode proteins, reflecting a wide range of non-coding genome with essential regulatory and structural roles. Understanding the endothelial cell function in vascular biology has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::157946a2a428e99ab5a4a38150327974
https://www.pure.ed.ac.uk/ws/files/343367316/Mitic_Caporali_R2_final.docx
https://www.pure.ed.ac.uk/ws/files/343367316/Mitic_Caporali_R2_final.docx
Autor:
Tijana Mitić
Publikováno v:
Journal of molecular endocrinology. 70(1)
Leading a research group as an early career researcher (ECR) in academia presents many challenges. First, it imposes many additional pressures on individuals, causing fear of missing out on a great opportunity that could advance your career. Together
Autor:
Tatiana Dudnakova, Hywel Dunn-Davies, Antonella Nogara, Julie Rodor, Anita Thomas, Elisa Parish, Philippe Gautier, Alison Meynert, Paolo Madeddu, Andrea Caporali, Andrew Baker, David Tollervey, Tijana Mitić
SummaryEnhancer of Zeste Homologue 2 (EZH2) modulates gene transcription during endothelial cell (EC) dysfunction, via interaction with non-coding RNAs (ncRNAs). Thus, EZH2 can act as a rheostat in deposition of histone H3K27 trimethylation (H3K27me3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11f0fb717df682d5efe2d51fec398ba8
https://doi.org/10.1101/2022.05.20.492787
https://doi.org/10.1101/2022.05.20.492787
Autor:
David Mellis, Andrea Martello, Domenico D'Arca, Lisa Imrie, Andrea Caporali, Noor Gammoh, John C. Dawson, Elisa Parish, Neil O. Carragher, Nicholas L. Mills, Angela Lauriola, Martina Vidmar, Mairi Brittan, Tijana Mitić
Publikováno v:
EMBO Reports
Martello, A, Lauriola, A, Mellis, D, Parish, E, Dawson, J C, Imrie, L, Vidmar, M, Gammoh, N, Mitić, T, Brittan, M, Mills, N L, Carragher, N O, D'arca, D & Caporali, A 2020, ' Trichoplein binds PCM1 and controls endothelial cell function by regulating autophagy ', EMBO Reports . https://doi.org/10.15252/embr.201948192
Martello, A, Lauriola, A, Mellis, D, Parish, E, Dawson, J C, Imrie, L, Vidmar, M, Gammoh, N, Mitić, T, Brittan, M, Mills, N L, Carragher, N O, D'arca, D & Caporali, A 2020, ' Trichoplein binds PCM1 and controls endothelial cell function by regulating autophagy ', EMBO Reports . https://doi.org/10.15252/embr.201948192
Autophagy is an essential cellular quality control process that has emerged as a critical one for vascular homeostasis. Here, we show that trichoplein (TCHP) links autophagy with endothelial cell (EC) function. TCHP localizes to centriolar satellites
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::252268a62a4ffc2874c85e117a1d5a01
https://hdl.handle.net/11380/1201619
https://hdl.handle.net/11380/1201619
Autor:
Loes M.H. Elemans, Mark G. MacAskill, Andrea Martello, Ayman Al Haj Zen, Andrea Caporali, Adriana Tavares, Ross A. Jones, Souzana Angel, David Mellis, Carlos Alcaide Corral, Tijana Mitić, Rachael O. Forsythe, David E. Newby, Michael L. Robinson, Andy Baker, Brad D. Wagner
Publikováno v:
Basic Science.
Introduction MicroRNAs (miRNAs) are small non-coding RNAs that orchestrate genetic networks by modulating simultaneous gene expression and regulates vascular function. Despite recent accumulation of experimental data and the emergence of functional m
Autor:
David Mellis, Domenico D'Arca, Martina Vidmar, Andrea Caporali, Neil O. Carragher, Angela Lauriola, Elisa Parish, Andrea Martello, Tijana Mitić, Mairi Brittan, Lisa Imrie, Nicholas L. Mills, John C. Dawson, Noor Gammoh
Autophagy is an essential cellular quality control process that emerged critical for vascular homeostasis. Here we describe, the role for Trichoplein (TCHP) protein in linking autophagy with endothelial cells (ECs) function. The depletion of TCHP in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::503c5eafd4509f622a9605f5c65fe90d
https://doi.org/10.1101/595702
https://doi.org/10.1101/595702
Autor:
Sadie C, Slater, Eva, Jover, Andrea, Martello, Tijana, Mitić, Iker, Rodriguez-Arabaolaza, Rosa, Vono, Valeria V, Alvino, Simon C, Satchell, Gaia, Spinetti, Andrea, Caporali, Paolo, Madeddu
Publikováno v:
Molecular Therapy
MicroRNAs regulate endothelial function and angiogenesis, but their implication in pericyte biology remains undetermined. A PCR array, covering a panel of 379 human microRNAs, showed microRNA-532-5p to be one of the most differentially modulated by h
Autor:
Gianni D Angelini, Marco Meloni, Raul Urrutia, Andrea Caporali, Ilaria Floris, Micol Marchetti, Costanza Emanueli, Tijana Mitić
Publikováno v:
Mitić, T, Caporali, A, Floris, I, Meloni, M, Marchetti, M, Urrutia, R, Angelini, G D & Emanueli, C 2015, ' EZH2 modulates angiogenesis in vitro and in a mouse model of limb ischemia ', Molecular Therapy, vol. 23, no. 1, pp. 32-42 . https://doi.org/10.1038/mt.2014.163
Molecular Therapy
Molecular Therapy
Epigenetic mechanisms may regulate the expression of pro-angiogenic genes, thus affecting reparative angiogenesis in ischemic limbs. The enhancer of zest homolog-2 (EZH2) induces thtrimethylation of lysine 27 on histone H3 (H3K27me3), which represses