Pancreatic β-cells package double C2-like domain beta protein into extracellular vesicles via tandem C2 domains

Autor: Diana Esparza, Carinna Lima, Sarah Abuelreich, Ima Ghaeli, Jinhee Hwang, Eunjin Oh, Ayelet Lenz, Angel Gu, Nan Jiang, Fouad Kandeel, Debbie C. Thurmond, Tijana Jovanovic-Talisman

Publikováno v: Frontiers in Endocrinology, Vol 15 (2024)

IntroductionDouble C2-like domain beta (DOC2B) is a vesicle priming protein critical for glucose-stimulated insulin secretion in β-cells. Individuals with type 1 diabetes (T1D) have lower levels of DOC2B in their residual functional β-cell mass and

Externí odkaz: https://doaj.org/article/49be9d7536124d169961b687cb510217

Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches

Autor: Joshua A. Welsh, Deborah C. I. Goberdhan, Lorraine O'Driscoll, Edit I. Buzas, Cherie Blenkiron, Benedetta Bussolati, Houjian Cai, Dolores Di Vizio, Tom A. P. Driedonks, Uta Erdbrügger, Juan M. Falcon‐Perez, Qing‐Ling Fu, Andrew F. Hill, Metka Lenassi, Sai Kiang Lim, Mỹ G. Mahoney, Sujata Mohanty, Andreas Möller, Rienk Nieuwland, Takahiro Ochiya, Susmita Sahoo, Ana C. Torrecilhas, Lei Zheng, Andries Zijlstra, Sarah Abuelreich, Reem Bagabas, Paolo Bergese, Esther M. Bridges, Marco Brucale, Dylan Burger, Randy P. Carney, Emanuele Cocucci, Rossella Crescitelli, Edveena Hanser, Adrian L. Harris, Norman J. Haughey, An Hendrix, Alexander R. Ivanov, Tijana Jovanovic‐Talisman, Nicole A. Kruh‐Garcia, Vroniqa Ku'ulei‐Lyn Faustino, Diego Kyburz, Cecilia Lässer, Kathleen M. Lennon, Jan Lötvall, Adam L. Maddox, Elena S. Martens‐Uzunova, Rachel R. Mizenko, Lauren A. Newman, Andrea Ridolfi, Eva Rohde, Tatu Rojalin, Andrew Rowland, Andras Saftics, Ursula S. Sandau, Julie A. Saugstad, Faezeh Shekari, Simon Swift, Dmitry Ter‐Ovanesyan, Juan P. Tosar, Zivile Useckaite, Francesco Valle, Zoltan Varga, Edwin van derPol, Martijn J. C. vanHerwijnen, Marca H. M. Wauben, Ann M. Wehman, Sarah Williams, Andrea Zendrini, Alan J. Zimmerman, MISEV Consortium, Clotilde Théry, Kenneth W. Witwer

Publikováno v: Journal of Extracellular Vesicles, Vol 13, Iss 2, Pp n/a-n/a (2024)

Abstract Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have gene

Externí odkaz: https://doaj.org/article/62d9f58d0f2b47e292d51b7893a73080

Using quantitative single molecule localization microscopy to optimize multivalent HER2-targeting ligands

Autor: Devin L. Wakefield, Ottavia Golfetto, Raphael Jorand, Sunetra Biswas, Kassondra Meyer, Kendra N. Avery, Cindy Zer, Eliedonna E. Cacao, Steven J. Tobin, Ian J. Talisman, John C. Williams, Tijana Jovanovic-Talisman

Publikováno v: Frontiers in Medicine, Vol 10 (2023)

IntroductionThe progression-free survival of patients with HER2-positive metastatic breast cancer is significantly extended by a combination of two monoclonal antibodies, trastuzumab and pertuzumab, which target independent epitopes of the extracellu

Externí odkaz: https://doaj.org/article/192df048a712400cb77bedb0f4526917

Phase 2 of extracellular RNA communication consortium charts next-generation approaches for extracellular RNA research

Autor: Bogdan Mateescu, Jennifer C. Jones, Roger P. Alexander, Eric Alsop, Ji Yeong An, Mohammad Asghari, Alex Boomgarden, Laura Bouchareychas, Alfonso Cayota, Hsueh-Chia Chang, Al Charest, Daniel T. Chiu, Robert J. Coffey, Saumya Das, Peter De Hoff, Andrew deMello, Crislyn D’Souza-Schorey, David Elashoff, Kiarash R. Eliato, Jeffrey L. Franklin, David J. Galas, Mark B. Gerstein, Ionita H. Ghiran, David B. Go, Stephen Gould, Tristan R. Grogan, James N. Higginbotham, Florian Hladik, Tony Jun Huang, Xiaoye Huo, Elizabeth Hutchins, Dennis K. Jeppesen, Tijana Jovanovic-Talisman, Betty Y.S. Kim, Sung Kim, Kyoung-Mee Kim, Yong Kim, Robert R. Kitchen, Vaughan Knouse, Emily L. LaPlante, Carlito B. Lebrilla, L. James Lee, Kathleen M. Lennon, Guoping Li, Feng Li, Tieyi Li, Tao Liu, Zirui Liu, Adam L. Maddox, Kyle McCarthy, Bessie Meechoovet, Nalin Maniya, Yingchao Meng, Aleksandar Milosavljevic, Byoung-Hoon Min, Amber Morey, Martin Ng, John Nolan, Getulio P. De Oliveira Junior, Michael E. Paulaitis, Tuan Anh Phu, Robert L. Raffai, Eduardo Reátegui, Matthew E. Roth, David A. Routenberg, Joel Rozowsky, Joseph Rufo, Satyajyoti Senapati, Sigal Shachar, Himani Sharma, Anil K. Sood, Stavros Stavrakis, Alessandra Stürchler, Muneesh Tewari, Juan P. Tosar, Alexander K. Tucker-Schwartz, Andrey Turchinovich, Nedyalka Valkov, Kendall Van Keuren-Jensen, Kasey C. Vickers, Lucia Vojtech, Wyatt N. Vreeland, Ceming Wang, Kai Wang, ZeYu Wang, Joshua A. Welsh, Kenneth W. Witwer, David T.W. Wong, Jianping Xia, Ya-Hong Xie, Kaichun Yang, Mikołaj P. Zaborowski, Chenguang Zhang, Qin Zhang, Angela M. Zivkovic, Louise C. Laurent

Publikováno v: iScience, Vol 25, Iss 8, Pp 104653- (2022)

Summary: The extracellular RNA communication consortium (ERCC) is an NIH-funded program aiming to promote the development of new technologies, resources, and knowledge about exRNAs and their carriers. After Phase 1 (2013–2018), Phase 2 of the progr

Externí odkaz: https://doaj.org/article/d72ed055b3ab4740b73e722d85b82959

The DARC Side of Inflamm-Aging: Duffy Antigen Receptor for Chemokines (DARC/ACKR1) as a Potential Biomarker of Aging, Immunosenescence, and Breast Oncogenesis among High-Risk Subpopulations

Autor: Nikita Jinna, Padmashree Rida, Tianyi Su, Zhihong Gong, Song Yao, Mark LaBarge, Rama Natarajan, Tijana Jovanovic-Talisman, Christine Ambrosone, Victoria Seewaldt

Publikováno v: Cells, Vol 11, Iss 23, p 3818 (2022)

The proclivity of certain pre-malignant and pre-invasive breast lesions to progress while others do not continues to perplex clinicians. Clinicians remain at a crossroads with effectively managing the high-risk patient subpopulation owing to the pauc

Externí odkaz: https://doaj.org/article/19db36f13ae044efa910bdff91a32b3a