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Development of a Mouse Model for Chronic Cat Allergen-Induced Asthma

Autor: Cecilia Kemi, K. Waden, Tiiu Saarne, Jeanette Grundström, Guro Gafvelin, Marianne van Hage, Marina C. Pils, Joshua A. Gregory, Mikael Adner

Publikováno v: International Archives of Allergy and Immunology. 165:195-205

Background: Allergic asthma is a chronic inflammatory airway disease caused by exposure to airborne allergens. In order to develop novel therapies for allergic asthma, models that are relevant to human disease are needed. Methods: Female BALB/c mice

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6df521761d9b914d855f8c15f41e7d3d
https://doi.org/10.1159/000369066

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Patient stratification and the unmet need in asthma

Autor: Gustav Johansson, Petra Hazon, Matthew C. Catley, Pernilla Glader, Tiiu Saarne, Linda Swedin, Maria Rehnberg, Magdalena Niedzielska

Publikováno v: Pharmacologytherapeutics. 169

Asthma is often described as an inflammatory disease of the lungs and in most patients symptomatic treatment with bronchodilators or inhaled corticosteroids is sufficient to control disease. Unfortunately there are a proportion of patients who fail t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::225ba7ba38084ce5ce99473a7f20df7f
https://pubmed.ncbi.nlm.nih.gov/27373855

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Covalent Coupling of Vitamin D3 to the Major Cat Allergen Fel d 1 Improves the Effects of Allergen-Specific Immunotherapy in a Mouse Model for Cat Allergy

Autor: Cecilia Kemi, Mats Andersson, Jeanette Grundström, Guro Gafvelin, Ola B. Nilsson, Theresa Neimert-Andersson, Tiiu Saarne, Marianne van Hage

Publikováno v: International Archives of Allergy and Immunology. 157:136-146

Background: Allergen-specific immunotherapy (SIT) is currently the only curative treatment for allergy but the treatment needs to be improved. We hypothesize that covalent coupling of immunomodulating vitamin D3 to the major cat allergen Fel d 1 can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8129dbb9774008f5f68033b3d76d38a7
https://doi.org/10.1159/000327546

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Treatment with a Fel d 1 hypoallergen reduces allergic responses in a mouse model for cat allergy

Autor: M. van Hage, Hans Grönlund, Theresa Neimert-Andersson, Guro Gafvelin, Marek Jutel, Tiiu Saarne

Publikováno v: Allergy. 66:255-263

Background: A hypoallergen of the major cat allergen Fel d 1, recombinant (r) Fel d 1 (DTE III), was previously shown to have retained T-cell reactivity and strongly reduced IgE-binding capacity compared to unmodified rFel d 1. Here, we evaluated the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9594795ecd7c9b3a34c622d68f600ea9
https://doi.org/10.1111/j.1398-9995.2010.02468.x

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Contents Vol. 151, 2010

Autor: Jesús Jurado-Palomo, Guro Gafvelin, Tiiu Saarne, Wei Guo, Philippe-Jean Bousquet, Hye Yung Yum, David H. Broide, Gergely Tibor Kozma, Laura Gilmartin, Salvatore Metafora, Salvatore De Maria, Torsten Zuberbier, András Szabó, Yang Zhao, Janet M. Oliver, Beáta Szebeni, Zsolt István Komlósi, Ana María Fiandor-Román, F. Al-Maskari, S. Al-Hammadi, Irina Bobolea, Amato de Paulis, Hans Grönlund, Santiago Quirce, Maria Cartenì, Tereassa Archibeque, Massimo Triggiani, Mark Schuyler, Nella Prevete, Dae Jin Song, György Losonczy, Jiong Yang, Éva Pállinger, Lajos Kovács, Ádám Vannay, George N. Konstantinou, Csaba Ádori, Jae Youn Cho, Cristina Y. Pascual, Gianpietro Ravagnan, Ya-dong Gao, R. Bernsen, Raffaele Ragone, Myung Goo Min, Lorena Diehl, Sofía Sánchez-Pastor, Gianni Marone, Christy A. Tarleton, Krisztina Rusai, Clifford Qualls, Francesca Wanda Rossi, Erna Sziksz, Marina Miller, Nikolaos G. Papadopoulos, Bridget S. Wilson, Marianne van Hage, Vittoria Metafora

Publikováno v: International Archives of Allergy and Immunology. 151:I-IV

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2fa4baf0aeaaf36890506187ca16322a
https://doi.org/10.1159/000299664

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Cloning and Characterisation of Two IgE-Binding Proteins, Homologous to Tropomyosin and α-Tubulin, from the Mite Lepidoglyphus destructor

Autor: Tiiu Saarne, Marianne van Hage-Hamsten, Guro Gafvelin, Liselotte Kaiser, Omid Rasool, Sonia Huecas

Publikováno v: International Archives of Allergy and Immunology. 130:258-265

Background: The dust mite Lepidoglyphus destructor is a major source of mite allergy in European rural environments, but it also causes allergy in urban populations around the world. We have previously cloned, sequenced and expressed several allergen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8c04529452db339449528fe10fa59538
https://doi.org/10.1159/000070212

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Characterization of the dog lipocalin allergen Can f 6: the role in cross-reactivity with cat and horse

Autor: Ola B. Nilsson, Hans Grönlund, Tiiu Saarne, A. Zoltowska, M. van Hage, Jonas Binnmyr

Publikováno v: Allergy. 67(6)

Background Allergy to the domestic dog (Canis familiaris) affects 5–10% of the population in affluent countries. Three of four patients are allergic to more than one pet, which can only partially be explained by cross-reactivity between serum album

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a65c4cdb22430b945a739a3d860b3410
https://pubmed.ncbi.nlm.nih.gov/23464491

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