Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Tiing Jen Loh"'
Autor:
Tiing Jen Loh, Jia Jia Lim, Claerwen M. Jones, Hien Thy Dao, Mai T. Tran, Daniel G. Baker, Nicole L. La Gruta, Hugh H. Reid, Jamie Rossjohn
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract CD4+ T cells recognising citrullinated self-epitopes presented by HLA-DRB1 bearing the shared susceptibility epitope (SE) are implicated in rheumatoid arthritis (RA). However, the underlying T cell receptor (TCR) determinants of epitope spec
Externí odkaz:
https://doaj.org/article/da55e0bd7eb74b1a926c2737875550c7
Publikováno v:
BIO Integration, Vol 3, Iss 3, Pp 124-131 (2022)
Externí odkaz:
https://doaj.org/article/dc58da2ce69d4fceae3b42e1ef16a457
Autor:
Sunghee Cho, Heegyum Moon, Tiing Jen Loh, Hyun Kyung Oh, Hey-Ran Kim, Myung-Geun Shin, D. Joshua Liao, Jianhua Zhou, Xuexiu Zheng, Haihong Shen
Publikováno v:
The Scientific World Journal, Vol 2014 (2014)
Spinal muscular atrophy (SMA) is a human genetic disease which occurs because of the deletion or mutation of SMN1 gene. SMN1 gene encodes the SMN protein which plays a key role in spliceosome assembly. Although human patients contain SMN2, a duplicat
Externí odkaz:
https://doaj.org/article/5569434416a9446aafce03d7631d558f
Autor:
Murray McKinnon, Nathan J. Felix, Nicole L. La Gruta, Claerwen M. Jones, Vivianne Malmström, Jia Jia Lim, Anthony W. Purcell, Jamie Rossjohn, Tiing Jen Loh, Yi Tian Ting, Daniel Baker, Pirooz Zareie, Lars Klareskog, Khai Lee Loh, Frederik Stevenaert, Anish Suri, Ravi Sharma, Hugh H. Reid
Publikováno v:
Science Immunology. 6
Individuals expressing HLA-DR4 bearing the shared susceptibility epitope (SE) have an increased risk of developing rheumatoid arthritis (RA). Posttranslational modification of self-proteins via citrullination leads to the formation of neoantigens tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::027b0aa9c31052a983280fabe4d7b531
https://doi.org/10.1126/sciimmunol.abe0896
https://doi.org/10.1126/sciimmunol.abe0896
Autor:
Namjeong Choi, Ha Na Jang, Heegyum Moon, Xuexiu Zheng, Jiyeon Ha, Michael B. Ye, Dong-Eun Kim, Tiing Jen Loh, Jianhua Zhou, Yongchao Liu, Haihong Shen, Sungchan Cho, Sunghee Cho, Jagyeong Oh
Publikováno v:
BMB REPORTS(50): 8
BMB Reports
BMB Reports
SRSF2, a Serine-Arginine rich (SR) protein, is a splicing activator that mediates exon inclusion and exclusion events equally well. Here we show SRSF2 directly suppresses intron splicing to suppress cassette exon inclusion in SMN premRNA. Through a s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::840c6dc34613434c2e716a793ae673aa
https://doi.org/10.5483/bmbrep.2017.50.8.103
https://doi.org/10.5483/bmbrep.2017.50.8.103
Autor:
Jianhua Zhou, Namjeong Choi, Heegyum Moon, Haihong Shen, Xuexiu Zheng, Tiing Jen Loh, Yongchao Liu, Ha Na Jang
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1860:363-373
Selection of 5' splice-sites (5'SS) in alternative splicing plays an important role in gene regulation. Although regulatory mechanisms of heterogeneous nuclear ribonucleoprotein L (hnRNP L), a well-known splicing regulatory protein, have been studied
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a82d1769087bb4ec4e22580ce68aaada
https://doi.org/10.1016/j.bbagrm.2017.01.010
https://doi.org/10.1016/j.bbagrm.2017.01.010
Autor:
Xuexiu Zheng, Darren R. Williams, Heegyum Moon, Tiing Jen Loh, Yongchao Liu, Ha Na Jang, Da-Woon Jung, Haihong Shen
Publikováno v:
Oncology Letters. 13:1944-1948
The récepteur d'origine nantais (RON) gene is a proto-oncogene that is responsible for encoding the human macrophage-stimulating protein (MSP) 1 receptor. MSP activation induces RON-mediated cell dissociation, migration and matrix invasion. Isoforms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a486e736b680f40a100e7ebd1f48e6d
https://doi.org/10.3892/ol.2017.5627
https://doi.org/10.3892/ol.2017.5627
Publikováno v:
BMB Reports
Clustered regularly-interspaced short palindromic repeats (CRISPR) is a new and effective genetic editing tool. CRISPR was initially found in bacteria to protect it from virus invasions. In the first step, specific DNA strands of virus are identified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e43acce3be33953d0c355476bf655eeb
http://europepmc.org/articles/PMC5319660
http://europepmc.org/articles/PMC5319660
Autor:
Tran, Mai T.1, Jia Jia Lim1, Tiing Jen Loh1, Mannering, Stuart I.2, Rossjohn, Jamie1,3 jamie.rossjohn@monash.edu, Reid, Hugh H.1 hugh.reid@monash.edu
Publikováno v:
Journal of Biological Chemistry. Sep2024, Vol. 300 Issue 9, p1-15. 15p.
Autor:
Woo Keun Song, Heegyum Moon, Sunghee Cho, Haihong Shen, Hyon E. Choy, Huyn Kyung Oh, Tiing Jen Loh, Sungchan Cho, Xuexiu Zheng, Jang-Soo Chun
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1839:306-315
Spinal muscular atrophy (SMA) is an autosomal recessive genetic disease, which causes death of motor neurons in the anterior horn of the spinal cord. Genetic cause of SMA is the deletion or mutation of SMN1 gene, which encodes the SMN protein. Althou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3172222dd6f5b58a9d4f584f1f8555d7
https://doi.org/10.1016/j.bbagrm.2014.02.006
https://doi.org/10.1016/j.bbagrm.2014.02.006