Výsledky vyhledávání - "Tiina Palomäki"

Oligonucleotide-based pharmaceuticals: Non-clinical and clinical safety signals and non-clinical testing strategies

Autor: Enni-Kaisa Mustonen, Markku Pasanen, Tiina Palomäki

Publikováno v: Regulatory Toxicology and Pharmacology. 90:328-341

Antisense oligonucleotides, short interfering RNAs (siRNAs) and aptamers are oligonucleotide-based pharmaceuticals with a promising role in targeted therapies. Currently, five oligonucleotide-based pharmaceuticals have achieved marketing authorizatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36f083a230d72250b472dd4d362bb461
https://doi.org/10.1016/j.yrtph.2017.09.028

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The PmrA‐PmrB two‐component system responding to acidic pH and iron controls virulence in the plant pathogenErwinia carotovorassp.carotovora

Autor: Heidi Hyytiäinen, Anne Tuikkala, Solveig Sjöblom, Tiina Palomäki, E. Tapio Palva

Publikováno v: Molecular Microbiology. 50:795-807

Summary Efficient response to environmental cues is crucial to successful infection by plant-pathogenic bacteria such as Erwinia carotovora ssp. carotovora . The expression of the main virulence genes of this pathogen, encoding extracellular enzymes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9849bf9863fa676c6d7073dce9b232f6
https://doi.org/10.1046/j.1365-2958.2003.03729.x

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Erwinia carotovora subsp. carotovora and Erwinia-Derived Elicitors HrpN and PehA Trigger Distinct but Interacting Defense Responses and Cell Death in Arabidopsis

Autor: Tarja Kariola, E. Tapio Palva, Günter Brader, Tiina Palomäki

Publikováno v: Molecular Plant-Microbe Interactions®. 16:179-187

We have used an hrp-positive strain of the soft rot pathogen Erwinia carotovora subsp. carotovora to elucidate plant responses to this bacterial necrotroph. Purified virulence determinants, harpin (HrpN) and polygalacturonase (PehA), were used as too

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https://doi.org/10.1094/mpmi.2003.16.3.179

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A putative three-dimensional targeting motif of polygalacturonase (PehA), a protein secreted through the type II (GSP) pathway inErwinia carotovora

Autor: Ruusu Riekki, Richard W. Pickersgill, Tiina Palomäki, H. T. Saarilahti, Martin Romantschuk

Publikováno v: Molecular Microbiology. 43:585-596

Intramolecular information specifying protein secretion through the type II (GSP) pathway of Gram-negative bacteria was investigated. Two regions of the polygalacturonase (PehA) of Erwinia carotovora containing residues proposed to be included in a t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8507e0d97cbb51c15b8f86b67705f282
https://doi.org/10.1046/j.1365-2958.2002.02793.x

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Risk of tumorigenicity in mesenchymal stromal cell-based therapies--bridging scientific observations and regulatory viewpoints

Autor: Paula Salmikangas, Olivier Lantz, Marcel Kwa, Peter Ahnert, Arnaud Foussat, Sophie Lucas-Samuel, Lisbeth Barkholt, Karin Tarte, Romaldas Mačiulaitis, Christian K. Schneider, Gérard Tachdjian, Dirk Büscher, Luc Sensebé, Tiina Palomäki, Lucie Tosca, Veronika Jekerle, Willem E. Fibbe, Egbert Flory, Louise Bisset

Publikováno v: Cytotherapy
Cytotherapy, Elsevier, 2013, 15 (7), pp.753-9. ⟨10.1016/j.jcyt.2013.03.005⟩
Cytotherapy, 2013, 15 (7), pp.753-9. ⟨10.1016/j.jcyt.2013.03.005⟩
Cytotherapy, 15(7), 753-759
Cytotherapy, Elsevier, 2013, 15 (7), pp.753-9. 〈10.1016/j.jcyt.2013.03.005〉

International audience; In the past decade, the therapeutic value of mesenchymal stromal cells (MSCs) has been studied in various indications, thereby taking advantage of their immunosuppressive properties. Easy procurement from bone marrow, adipose

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https://hal-univ-rennes1.archives-ouvertes.fr/hal-00874732

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The extreme C-terminus is required for secretion of both the native polygalacturonase (PehA) and PehA-Bla hybrid proteins in Erwinia carotovora subsp. carotovora

Autor: H. T. Saarilahti, Tiina Palomäki

Publikováno v: Molecular Microbiology. 17:449-459

A set of gene fusions was constructed between the pehA gene encoding the secreted endopolygalacturonase (PehA) and the bla gene coding for a normally periplasmic beta-lactamase (Bla). The resulting hybrid proteins were specifically and actively route

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https://doi.org/10.1111/j.1365-2958.1995.mmi_17030449.x

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Distinct differentiation characteristics of individual human embryonic stem cell lines

Autor: Timo Tuuri, Nina Horelli-Kuitunen, Sakari Knuutila, Karolina Lundin, Timo Otonkoski, Jaan Palgi, Tiina Palomäki, Jarkko Ustinov, Cia Olsson, Milla Mikkola

Publikováno v: BMC Developmental Biology
BMC Developmental Biology, Vol 6, Iss 1, p 40 (2006)

Background Individual differences between human embryonic stem cell (hESC) lines are poorly understood. Here, we describe the derivation of five hESC lines (called FES 21, 22, 29, 30 and 61) from frozen-thawed human embryos and compare their individu

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https://pubmed.ncbi.nlm.nih.gov/16895598

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A putative three-dimensional targeting motif of polygalacturonase (PehA), a protein secreted through the type II (GSP) pathway in Erwinia carotovora

Autor: Tiina, Palomäki, Richard, Pickersgill, Ruusu, Riekki, Martin, Romantschuk, Hannu T, Saarilahti

Publikováno v: Molecular microbiology. 43(3)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9306ec507443603495d67bee231f9e0d
https://pubmed.ncbi.nlm.nih.gov/11929517

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Members of the amylovora group of Erwinia are cellulolytic and possess genes homologous to the type II secretion pathway

Autor: H. T. Saarilahti, Ruusu Riekki, Martin Romantschuk, Harri Kokko, Tiina Palomäki, O. Virtaharju

Publikováno v: Moleculargeneral genetics : MGG. 263(6)

A cellulase-producing clone was isolated from a genomic library of the Erwinia rhapontici (Millard) Burkholder strain NCPPB2989. The corresponding gene, named celA, encodes an endoglucanase (EC 3.2.1.4) with the extremely low pH optimum of 3.4 and a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8759c2da1f65354473a15fe394bbce6f
https://pubmed.ncbi.nlm.nih.gov/10954089

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