Výsledky vyhledávání - "Tiina Kuulasmaa"

Link Between GIP and Osteopontin in Adipose Tissue and Insulin Resistance

Publikováno v: Diabetes; Vol 62
Diabetes

Low-grade inflammation in obesity is associated with accumulation of the macrophage-derived cytokine osteopontin (OPN) in adipose tissue and induction of local as well as systemic insulin resistance. Since glucose-dependent insulinotropic polypeptide

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Association of indices of liver and adipocyte insulin resistance with 19 confirmed susceptibility loci for type 2 diabetes in 6,733 non-diabetic Finnish men

Autor: Alena Stančáková, Tiina Kuulasmaa, Jussi Pihlajamäki, Markku Laakso, Teemu Kuulasmaa, Eleuterio Ferrannini, Jussi Paananen, Johanna Kuusisto, Jagadish Vangipurapu

Publikováno v: Diabetologia. 54:563-571

Of the confirmed type 2 diabetes susceptibility loci only a few are known to affect insulin sensitivity. We examined the association of indices of hepatic and adipocyte insulin resistance (IR) with 19 confirmed type 2 diabetes risk loci in a large po

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https://doi.org/10.1007/s00125-010-1977-4

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The genetic variation in the tenomodulin gene is associated with serum total and LDL cholesterol in a body size-dependent manner

Autor: Johanna Kuusisto, Ursula Schwab, Marjukka Kolehmainen, Tiina Kuulasmaa, Tolppanen Am, M. I. J. Uusitupa, Leena Pulkkinen, Jon Lindstrom, Jaakko Tuomilehto

Publikováno v: International Journal of Obesity. 32:1868-1872

We have reported that the sequence variation in the tenomodulin (TNMD) gene is associated with the risk of type 2 diabetes (T2DM), central obesity and serum levels of systemic immune mediators in the Finnish Diabetes Prevention Study (DPS), which is

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https://doi.org/10.1038/ijo.2008.217

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WNT-4mRNA Expression in Human Adrenocortical Tumors and Cultured Adrenal Cells

Autor: Jarmo Jääskeläinen, Sirpa Aaltomaa, Veli-Matti Kosma, Tiina Kuulasmaa, Suvikki Suppola, Päivi Heikkilä, Raimo Voutilainen, T Pietiläinen

Publikováno v: Hormone and Metabolic Research. 40:668-673

The members of the Wnt glycoprotein family are important in embryogenesis and adult tissue homeostasis, and deletion of WNT-4 gene in mice leads to improper development of many organs including the adrenals. The objective of this study was to investi

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https://doi.org/10.1055/s-2008-1078716

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ACTH Receptor Promoter Polymorphism Associates With Severity of Premature Adrenarche and Modulates Hypothalamo-Pituitary-Adrenal Axis in Children

Autor: Tiina Kuulasmaa, Jarmo Jääskeläinen, Raimo Voutilainen, Pauliina Utriainen, Saila Lappalainen

Publikováno v: Pediatric Research. 63:410-414

The genetic mechanisms underlying the regulation of adrenarche are unknown. The aim of the study was to find out whether ACTH receptor (MC2R) promoter polymorphism associates with premature adrenarche (PA) and its characteristics. DNA samples of 74 p

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https://doi.org/10.1203/pdr.0b013e3181659c14

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Androgen receptor gene CAG repeat length in women with metabolic syndrome

Autor: Maritta Hippeläinen, Leo Niskanen, Sangita Kurl, Jarmo Jääskeläinen, Raimo Voutilainen, Tiina Kuulasmaa, Matti Vanhala, Seija Korhonen, Seppo Heinonen

Publikováno v: Gynecological Endocrinology. 24:411-416

The length of the androgen receptor gene CAG repeat [AR (CAG)(n)] modulates the activity of the androgen receptor (AR), and this polymorphism has been shown to modulate body fat mass and serum concentrations of insulin in men. We hypothesized that sh

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https://doi.org/10.1080/09513590802210865

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Tumor Necrosis Factor-α Regulates Steroidogenesis, Apoptosis, and Cell Viability in the Human Adrenocortical Cell Line NCI-H295R

Autor: Irina V. Mikhaylova, Jarmo Jääskeläinen, Raimo Voutilainen, Tiina Kuulasmaa

Publikováno v: Endocrinology. 148:386-392

TNF-alpha regulates the hypothalamo-pituitary-adrenal axis at several levels. It has been shown to modify adrenal steroidogenesis in many species, and it is supposed to act as an auto/paracrine factor. However, its significance in human adrenocortica

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https://doi.org/10.1210/en.2006-0726

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Expression of Activin/Inhibin Receptor and Binding Protein Genes and Regulation of Activin/Inhibin Peptide Secretion in Human Adrenocortical Cells

Autor: Tiina Kuulasmaa, T Vanttinen, Jianqi Liu, Raimo Voutilainen

Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 87:4257-4263

Activins and inhibins are glycoprotein hormones produced mainly in gonads but also in other organs. They are believed to be important para/autocrine regulators of various cell functions. We investigated activin/inhibin receptor and binding protein ge

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https://doi.org/10.1210/jc.2002-020460

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Adipose tissue TCF7L2 splicing is regulated by weight loss and associates with glucose and fatty acid metabolism

Autor: Matti Pääkkönen, Sari Venesmaa, Pirjo Käkelä, Dorota Kaminska, Helena Gylling, Markku Laakso, Leena Pulkkinen, Maija Vaittinen, Tiina Kuulasmaa, Jussi Pihlajamäki

Publikováno v: Diabetes

We investigated the effects of obesity surgery-induced weight loss on transcription factor 7-like 2 gene (TCF7L2) alternative splicing in adipose tissue and liver. Furthermore, we determined the association of TCF7L2 splicing with the levels of plasm

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https://pubmed.ncbi.nlm.nih.gov/23093653

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