Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Tihomira I. Todorova"'
Autor:
Jiahao Chen, Cristina Montagna, Britta Will, David Reynolds, Amit Verma, Yun Ruei Kao, Ulrich Steidl, Daqian Sun, Swathi Rao Narayanagari, Tihomira I. Todorova
Publikováno v:
Nature medicine
Myelodysplastic syndromes (MDS) frequently progress to acute myeloid leukemia (AML); however, the cells leading to malignant transformation have not been directly elucidated. As progression of MDS to AML in humans provides a biological system to dete
Autor:
Boris Bartholdy, Jacqueline Boultwood, Guillermina Lozano, Yinghui Song, Emily Schwenger, Kith Pradhan, Shunbin Xiong, Rajni Kumari, Ulrich Steidl, Daqian Sun, Swathi Rao Narayanagari, Amit Verma, Hiroki Goto, Koki Ueda, Cristina Montagna, Andrea Pellagatti, Jidong Shan, Tihomira I. Todorova, Samuel J. Taylor, Oliver Bohorquez, Jiahao Chen, Justin C. Wheat, Luis A. Carvajal
Publikováno v:
Cancer Cell
MDMX is overexpressed in the vast majority of patients with acute myeloid leukemia (AML). We report that MDMX overexpression increases preleukemic stem cell (pre-LSC) number and competitive advantage. Utilizing five newly generated murine models, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff5bd26d9c60fe34d0e3a085fc39bd57
https://ora.ox.ac.uk/objects/uuid:9150de2b-5abb-4d1d-919d-d6fbedde1c76
https://ora.ox.ac.uk/objects/uuid:9150de2b-5abb-4d1d-919d-d6fbedde1c76
Autor:
Kelly Mitchell, Tihomira I. Todorova, Laura Barreyro, Joana Leite, Iléana Antony-Debré, Ioannis Mantzaris, Amit Verma, Samuel J. Taylor, Elisabeth Paietta, Gopichand Pendurti, Swathi Rao Narayanagari, Ulrich Steidl, Luis A. Carvajal, Zubair Piperdi, Kira Gritsman
Publikováno v:
The Journal of Experimental Medicine
IL1RAP is an emerging target for AML therapy. Studying its cell-intrinsic function revealed that IL1RAP interacts with and amplifies signaling through c-KIT and FLT3 in AML cells. This novel promiscuous role of IL1RAP in AML has implications for ther
Autor:
Kira Gritsman, Ulrich Steidl, Hideki Makishima, Britta Will, Richard T. Piszczatowski, Wendy M. McKimpson, Cassandra M. Hirsch, Kelly Mitchell, Christine McMahon, Boris Bartholdy, Swathi Rao Narayanagari, Richard N. Kitsis, Robert F. Stanley, Tihomira I. Todorova, Jaroslaw P. Maciejewski, Dagmar Walter
Publikováno v:
Journal of Experimental Medicine. 214:753-771
Despite the identification of several oncogenic driver mutations leading to constitutive JAK–STAT activation, the cellular and molecular biology of myeloproliferative neoplasms (MPN) remains incompletely understood. Recent discoveries have identifi
Autor:
Kith Pradhan, Daqian Sun, Tihomira I. Todorova, Swathi-Rao Narayanagari, Samuel J. Taylor, Oliver Bohorquez, Boris Bartholdy, Guillermina Lozano, Jiahao Chen, Shunbin Xiong, Luis A. Carvajal, Emily Schwenger, Jidong Shan, Justin C. Wheat, Ulrich Steidl, Koki Ueda, Hiroki Goto, Cristina Montagna, Rajni Kumari, Amit Verma, Yinghui Song
Publikováno v:
Experimental Hematology. 88:S27-S28
The p53 inhibitor MDMX is overexpressed in the vast majority of patients with AML; however, a causative role of MDMX in leukemogenesis has not yet been investigated. Mdmx transgenic mice (Mdmx-Tg) displayed increased number, proliferation and competi
Autor:
Tihomira I. Todorova, Rudolf S N Fehrmann, Marjan Geugien, Edo Vellenga, Hein Schepers, Ulrich Steidl, Annet Z. Brouwers-Vos, Patrick M. Korthuis, Katharina Mattes
Publikováno v:
Experimental Hematology, 73, 38-49. ELSEVIER SCIENCE INC
Reduced expression of the transcription factor PU.1 is frequently associated with development of acute myeloid leukemia (AML), whereas elevated levels of CITED2 (CBP/p300-interacting-transactivator-with-an-ED-rich-tail 2) enhance maintenance of both
Autor:
Maria M. Aivalioti, Yun Ruei Kao, Jiahao Chen, Amit Verma, James B. Bussel, Britta Will, Ioannis Mantzaris, Celine Pallaud, Tihomira I. Todorova, Ulrich Steidl, Mariana da Silva Ferreira, Swathi Rao Narayanagari, Pedro Marques Ramos, Aditi Shastri
Publikováno v:
Sci Transl Med
Eltrombopag (EP), a small molecule thrombopoietin receptor (TPO-R) agonist and potent intracellular iron chelator, has shown remarkable efficacy in stimulating sustained multilineage hematopoiesis in patients with bone marrow failure syndromes, sugge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6494208dba85803b997fb75c26b7d28
https://europepmc.org/articles/PMC9899005/
https://europepmc.org/articles/PMC9899005/
Autor:
Sonja Schaetzlein, Boris Bartholdy, Mariana da Silva Ferreira, Swathi Rao Narayanagari, Johanna van Oers, Ulrich Steidl, Jiahao Chen, Britta Will, Laura Barreyro, Amit Verma, Tihomira I. Todorova, Winfried Edelmann, Luis A. Carvajal, Michael Roth, Thomas O. Vogler, Jillian Mayer, Christine McMahon, Yiting Yu, Daniela Ben Neriah
Publikováno v:
Nature Medicine. 21:1172-1181
Modest transcriptional changes caused by genetic or epigenetic mechanisms are frequent in human cancer. Although loss or near-complete loss of the hematopoietic transcription factor PU.1 induces acute myeloid leukemia (AML) in mice, a similar degree
Autor:
Victor Thiruthuvanathan, Charles A. Kenworthy, Vincent Guerlavais, Swathi Rao Narayanagari, Manuel Aivado, Robert H. Singer, Robert A. Coleman, Tatyana Yatsenko, Daniela Ben Neriah, Amit Verma, Ulrich Steidl, Lumie Benard, Luis A. Carvajal, Adrien Senecal, Jesus Anampa, Britta Will, Justin C. Wheat, D. Allen Annis, Kelly Mitchell, Boris Bartholdy, Ioannis Mantzaris, Tihomira I. Todorova
Publikováno v:
Science translational medicine. 10(436)
The tumor suppressor p53 is often inactivated via its interaction with endogenous inhibitors mouse double minute 4 homolog (MDM4 or MDMX) or mouse double minute 2 homolog (MDM2), which are frequently overexpressed in patients with acute myeloid leuke
Autor:
Robert F, Stanley, Richard T, Piszczatowski, Boris, Bartholdy, Kelly, Mitchell, Wendy M, McKimpson, Swathi, Narayanagari, Dagmar, Walter, Tihomira I, Todorova, Cassandra, Hirsch, Hideki, Makishima, Britta, Will, Christine, McMahon, Kira, Gritsman, Jaroslaw P, Maciejewski, Richard N, Kitsis, Ulrich, Steidl
Publikováno v:
The Journal of Experimental Medicine
Stanley et al. show that loss of Nol3 in mice leads to a myeloproliferative phenotype resembling primary myelofibrosis, with activation of JAK–STAT signaling and significant cellular and molecular resemblance to human disease. These findings provid