Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Tigran V. Chalikian"'
Autor:
Tigran V. Chalikian
Publikováno v:
Life, Vol 12, Iss 9, p 1325 (2022)
It is an exciting experience to serve as guest editor for a Special Issue celebrating the 75th birthday of Professor Kenneth J [...]
Externí odkaz:
https://doaj.org/article/df3eb975aa5f4d32a97993744b1ad9b0
Autor:
Lily Scott, Tigran V. Chalikian
Publikováno v:
Life, Vol 12, Iss 4, p 597 (2022)
Once it had been realized that G-quadruplexes exist in the cell and are involved in regulation of genomic processes, the quest for ligands recognizing these noncanonical structures was underway. Many organic compounds that tightly associate with G-qu
Externí odkaz:
https://doaj.org/article/74a25eba44464c9aa075f93216263dbe
Publikováno v:
Biology, Vol 10, Iss 8, p 813 (2021)
Four-stranded non-canonical DNA structures including G-quadruplexes and i-motifs have been found in the genome and are thought to be involved in regulation of biological function. These structures have been implicated in telomere biology, genomic ins
Externí odkaz:
https://doaj.org/article/33cceb8a60cf4c3c865dbeb5ffd7941b
Publikováno v:
The Journal of Physical Chemistry B. 126:6654-6670
We employed a previously described procedure, based on circular dichroism (CD) spectroscopy, to quantify the distribution of conformational states adopted by equimolar mixtures of complementary G-rich and C-rich DNA strands from the promoter regions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::478a581a02a085e99fa3b5ba2b55013d
https://doi.org/10.1021/acs.jpcb.2c04304
https://doi.org/10.1021/acs.jpcb.2c04304
Autor:
David N. Dubins, Lutan Liu, Nabeel Tariq, Takuma Kume, Lily Scott, Robert B. Macgregor, Tigran V. Chalikian
Publikováno v:
The Journal of Physical Chemistry B. 125:7406-7416
The kinetic and thermodynamic stabilities of G-quadruplex structures have been extensively studied. In contrast, systematic investigations of the volumetric properties of G-quadruplexes determining their pressure stability are still relatively scarce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b70535d87b58b0c0cde38fa2ca305223
https://doi.org/10.1021/acs.jpcb.1c04075
https://doi.org/10.1021/acs.jpcb.1c04075
Publikováno v:
The Journal of Physical Chemistry B. 124:751-762
We characterized the conformational preferences of DNA in an equimolar mixture of complementary G-rich and C-rich strands from the promoter region of the c-MYC oncogene. Our CD-based approach presupposes that the CD spectrum of such a mixture is the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5319df2b4d4a8c1256937175e229339
https://doi.org/10.1021/acs.jpcb.9b10518
https://doi.org/10.1021/acs.jpcb.9b10518
Publikováno v:
Handbook of Chemical Biology of Nucleic Acids ISBN: 9789811613135
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed2492d994c550fdef8832a7c130affe
https://doi.org/10.1007/978-981-16-1313-5_3-1
https://doi.org/10.1007/978-981-16-1313-5_3-1
Publikováno v:
Biophysical Journal. 122:212a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5bdfa858600f133886704bb9edf07d0a
https://doi.org/10.1016/j.bpj.2022.11.1271
https://doi.org/10.1016/j.bpj.2022.11.1271
Publikováno v:
Biophysical Journal. 121:62a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dbc616ab5875834aed1189518f7f3c1a
https://doi.org/10.1016/j.bpj.2021.11.2378
https://doi.org/10.1016/j.bpj.2021.11.2378
Publikováno v:
Journal of the American Chemical Society. 140:2229-2238
G-quadruplexes and i-motifs are noncanonical secondary structures of DNA that appear to play a number of regulatory roles in the genome with clear connection to disease. Characterization of the forces stabilizing these structures is necessary for dev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::173ac1eb828b65b156b230a463fab1fa
https://doi.org/10.1021/jacs.7b11537
https://doi.org/10.1021/jacs.7b11537