Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Tigist Y. Tamir"'
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Abstract The Published Kinase Inhibitor Set (PKIS) is a publicly-available chemogenomic library distributed to more than 300 laboratories by GlaxoSmithKline (GSK) between 2011 and 2015 and by SGC-UNC from 2015 to 2017. Screening this library of well-
Externí odkaz:
https://doaj.org/article/2427271ceabc4a4d9e480023fca08c5f
Autor:
Natalie R. Melton, J. Matthew Cowan, Tigist Y. Tamir, Jennifer L. Bocanegra, Barbara M. Fujita, Michael B. Major, Omar A. Quintero, Elizabeth L. Schinski
Publikováno v:
Cytoskeleton (Hoboken)
MYO19 interacts with mitochondria through a C-terminal membrane association domain (MyMOMA). Specific mechanisms for localization of MYO19 to mitochondria are poorly understood. Using promiscuous biotinylation data in combination with existing affini
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
Scientific Reports
The Published Kinase Inhibitor Set (PKIS) is a publicly-available chemogenomic library distributed to more than 300 laboratories by GlaxoSmithKline (GSK) between 2011 and 2015 and by SGC-UNC from 2015 to 2017. Screening this library of well-annotated
Autor:
Bernard E. Weissman, Liza Makowski, Tigist Y. Tamir, Stephanie A. Montgomery, Seth J. Weir, Travis P. Schrank, Tuong T. Nguyen, Scott H. Randell, Travis S. Ptacek, D. Neil Hayes, Jeremy M. Simon, Kathleen M. Mulvaney, Brittany M. Bowman, Michael B. Major, Xiaoxin L Chen, Ryan M. Murphy
Publikováno v:
J Pathol
Activation of the nuclear factor (erythroid-derived 2)-like 2 (NFE2L2 or NRF2) transcription factor is a critical and evolutionarily conserved cellular response to oxidative stress, metabolic stress, and xenobiotic insult. Deficiency of NRF2 results
Autor:
Seth J. Weir, Tigist Y. Tamir, Priscila F. Siesser, Bernard E. Weissman, Trent Stohrer, M. Ben Major, Dennis Goldfarb, Brittany M. Bowman, Ryan M. Murphy, Kyle M. LaPak, Travis P. Schrank, Andrew E. Hale, Megan J. Agajanian, Nathaniel J. Moorman
Publikováno v:
J Cell Sci
Nuclear factor erythroid 2-related factor 2 (NFE2L2, also known as NRF2) is a transcription factor and master regulator of cellular antioxidant response. Aberrantly high NRF2-dependent transcription is recurrent in human cancer, but conversely NRF2 a
Publikováno v:
Current Opinion in Toxicology. 1:118-124
Mass spectrometry-based proteomic technologies continue to illuminate the mechanism(s) and physiological importance of the KEAP1/NRF2 antioxidant signaling pathway. Proteomic analysis of the KEAP1 and NRF2 protein complex has revealed associated prot
Autor:
Timothy M. Jacobs, Erica W. Cloer, Jacob Peter Matson, Jeanette Gowen Cook, Tigist Y. Tamir, Cyrus Vaziri, Priscila F. Siesser, Dennis Goldfarb, Michael B. Major, Joseph S. Harrison, Kathleen M. Mulvaney
Publikováno v:
Journal of Biological Chemistry. 291:23719-23733
KEAP1 is a substrate adaptor protein for a CUL3-based E3 ubiquitin ligase. Ubiquitylation and degradation of the antioxidant transcription factor NRF2 is considered the primary function of KEAP1; however, few other KEAP1 substrates have been identifi
Autor:
Natalie R. Melton, Omar A. Quintero, Elizabeth L. Schinski, Barbara M. Fujita, Tigist Y. Tamir, J. Matthew Cowan, M. Ben Major, Jennifer L. Bocanegra
MYO19 interacts with mitochondria through a C-terminal membrane association domain (MyMOMA). The specific mechanisms for localization of MYO19 to mitochondria are poorly understood. Using new promiscuous biotinylation data in combination with existin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1e82ca0541b6cd60e7bc98cefd45d36
https://doi.org/10.1101/602938
https://doi.org/10.1101/602938
Autor:
Jordan Kardos, Tigist Y. Tamir, Yang Yang, Cyrus Vaziri, William Y. Kim, Michael B. Major, Bernard E. Weissman, Elizabeth Mutter-Rottmayer, Yanzhe Gao
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-17 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-17 (2018)
The Cancer/Testes (CT) Antigen HORMAD1 is germ cell-restricted and plays developmental roles in generation and processing of meiotic DNA Double Strand Breaks (DSB). Many tumors aberrantly overexpress HORMAD1 yet the potential impact of this CT antige
Autor:
Ron Lahav, Hanoch Senderowitz, Sophia Zilber, Paul F. Bradfield, Beat A. Imhof, Netali Khazanov, M. Ben Major, Raanan Margalit, Evgenia Alpert, Tigist Y. Tamir, Eliav Blum, Shirin Kahremany, Nimrod Yosef Keshet-Levy, Tamar Getter, Laura Levy, Arie Gruzman
Publikováno v:
Bioorganic Chemistry. 92:103250
Leukocyte transendothelial migration is one of the most important step in launching an inflammatory immune response and chronic inflammation can lead to devastating diseases. Leukocyte migration inhibitors are considered as promising and potentially