Hypertrophy induced KIF5B controls mitochondrial localization and function in neonatal rat cardiomyocytes

Autor: Tigchelaar, Wardit, de Jong, Anne Margreet, Bloks, Vincent W., van Gilst, Wiek H., de Boer, Rudolf A., Silljé, Herman H.W.

Publikováno v: In Journal of Molecular and Cellular Cardiology August 2016 97:70-81

AKIP1, a Cardiac Hypertrophy Induced Protein that Stimulates Cardiomyocyte Growth via the Akt Pathway.

Autor: Hongjuan Yu^1,2 h.yu@umcg.nl, Tigchelaar, Wardit¹ w.tigchelaar@umcg.nl, Bo Lu^1,3 bolu80@gmail.com, van Gilst, Wiek H.¹ w.h.van.gilst@umcg.nl, de Boer, Rudolf A.¹ r.a.de.boer@umcg.nl, Westenbrink, B. Daan¹ b.d.westenbrink@umcg.nl, Silljé, Herman H. W.¹ h.h.w.sillje@umcg.nl

Publikováno v: International Journal of Molecular Sciences. Nov2013, Vol. 14 Issue 11, p21378-21393. 21p.

In EXOG-depleted cardiomyocytes cell death is marked by a decreased mitochondrial reserve capacity of the electron transport chain

Autor: Tigchelaar, Wardit, De Jong, Anne Margreet, van Gilst, Wiek H., De Boer, Rudolf A., Sillje, Herman H. W.

Publikováno v: BioEssays, 38, S136-S145. Wiley

Depletion ofmitochondrial endo/exonuclease G-like (EXOG) in cultured neonatal cardiomyocytes stimulates mitochondrial oxygen consumption rate (OCR) and induces hypertrophy via reactive oxygen species (ROS). Here, we show that neurohormonal stress tri

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https://research.rug.nl/en/publications/8536d8dd-11c4-411e-8761-01666c1e3fac

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In EXOG-depleted cardiomyocytes cell death is marked by a decreased mitochondrial reserve capacity of the electron transport chain.

Autor: Tigchelaar W; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., De Jong AM; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., van Gilst WH; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., De Boer RA; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Silljé HH; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Publikováno v: BioEssays : news and reviews in molecular, cellular and developmental biology [Bioessays] 2016 Jul; Vol. 38 Suppl 1, pp. S136-45.