Phenotype prediction using biologically interpretable neural networks on multi-cohort multi-omics data.

Autor: van Hilten, Arno, van Rooij, Jeroen, Heijmans, Bastiaan T., 't Hoen, Peter A. C., Meurs, Joyce van, Jansen, Rick, Franke, Lude, Boomsma, Dorret I., Pool, René, van Dongen, Jenny, Hottenga, Jouke J., van Greevenbroek, Marleen M. J., Stehouwer, Coen D. A., van der Kallen, Carla J. H., Schalkwijk, Casper G., Wijmenga, Cisca, Zhernakova, Sasha, Tigchelaar, Ettje F., Slagboom, P. Eline, Beekman, Marian

Publikováno v: NPJ Systems Biology & Applications; 8/2/2024, Vol. 10 Issue 1, p1-10, 10p

Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity

Autor: Zhernakova, Alexandra, Kurilshikov, Alexander, Bonder, Marc Jan, Tigchelaar, Ettje F., Schirmer, Melanie, Vatanen, Tommi, Mujagic, Zlatan, Vila, Arnau Vich, Falony, Gwen, Vieira-Silva, Sara, Wang, Jun, Imhann, Floris, Brandsma, Eelke, Jankipersadsing, Soesma A., Joossens, Marie, Cenit, Maria Carmen, Deelen, Patrick, Swertz, Morris A., study, LifeLines cohort, Weersma, Rinse K., Feskens, Edith J. M., Netea, Mihai G., Gevers, Dirk, Jonkers, Daisy, Franke, Lude, Aulchenko, Yurii S., Huttenhower, Curtis, Raes, Jeroen, Hofker, Marten H., Xavier, Ramnik J., Wijmenga, Cisca, Fu, Jingyuan

Publikováno v: Science, 2016 Apr . 352(6285), 565-569.

Externí odkaz: http://www.jstor.org/stable/24744865

Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour

Autor: Mills, Melinda C., Tropf, Felix C., Brazel, David M., van Zuydam, Natalie, Vaez, Ahmad, Agbessi, Mawussé, Ahsan, Habibul, Alves, Isabel, Andiappan, Anand Kumar, Arindrarto, Wibowo, Awadalla, Philip, Battle, Alexis, Beutner, Frank, Jan Bonder, Marc, Boomsma, Dorret I., Christiansen, Mark W., Claringbould, Annique, Deelen, Patrick, Esko, Tõnu, Favé, Marie-Julie, Franke, Lude, Frayling, Timothy, Gharib, Sina A., Gibson, Greg, Heijmans, Bastiaan T., Hemani, Gibran, Jansen, Rick, Kähönen, Mika, Kalnapenkis, Anette, Kasela, Silva, Kettunen, Johannes, Kim, Yungil, Kirsten, Holger, Kovacs, Peter, Krohn, Knut, Kronberg, Jaanika, Kukushkina, Viktorija, Kutalik, Zoltan, Lee, Bernett, Lehtimäki, Terho, Loeffler, Markus, Marigorta, Urko M., Mei, Hailang, Milani, Lili, Montgomery, Grant W., Müller-Nurasyid, Martina, Nauck, Matthias, Nivard, Michel G., Penninx, Brenda W. J. H., Perola, Markus, Pervjakova, Natalia, Pierce, Brandon L., Powell, Joseph, Prokisch, Holger, Psaty, Bruce M., Raitakari, Olli T., Ripatti, Samuli, Rotzschke, Olaf, Rüeger, Sina, Saha, Ashis, Scholz, Markus, Schramm, Katharina, Seppälä, Ilkka, Slagboom, Eline P., Stehouwer, Coen D. A., Stumvoll, Michael, Sullivan, Patrick, ‘t Hoen, Peter A. C., Teumer, Alexander, Thiery, Joachim, Tong, Lin, Tönjes, Anke, van Dongen, Jenny, van Iterson, Maarten, van Meurs, Joyce, Veldink, Jan H., Verlouw, Joost, Visscher, Peter M., Völker, Uwe, Võsa, Urmo, Westra, Harm-Jan, Wijmenga, Cisca, Yaghootkar, Hanieh, Yang, Jian, Zeng, Biao, Zhang, Futao, Isaacs, Aaron, Pool, René, Jan Hottenga, Jouke, van Greevenbroek, Marleen M. J., van der Kallen, Carla J. H., Schalkwijk, Casper G., Zhernakova, Sasha, Tigchelaar, Ettje F., Beekman, Marian, Deelen, Joris, van Heemst, Diana, van den Berg, Leonard H., van Duijn, Cornelia M., Hofman, Bert A., Uitterlinden, André G., Jhamai, P. Mila, Verbiest, Michael, Suchiman, H. Eka D., Verkerk, Marijn, van der Breggen, Ruud, van Rooij, Jeroen, Lakenberg, Nico, Mei, Hailiang, van Galen, Michiel, Bot, Jan, Zhernakova, Dasha V., van ’t Hof, Peter, Nooren, Irene, Moed, Matthijs, Vermaat, Martijn, Luijk, René, van Dijk, Freerk, Kielbasa, Szymon M., Swertz, Morris A., van Zwet, Erik. W., Akimova, Evelina T., Bergmann, Sven, Boardman, Jason D., Brumat, Marco, Buring, Julie E., Cesarini, David, Chasman, Daniel I., Chavarro, Jorge E., Cocca, Massimiliano, Concas, Maria Pina, Davey-Smith, George, Davies, Gail, Deary, Ian J., Franco, Oscar, Gaskins, Audrey J., de Geus, Eco J. C., Gieger, Christian, Girotto, Giorgia, Grabe, Hans Jörgen, Gunderson, Erica P., Harris, Kathleen Mullan, Hartwig, Fernando P., He, Chunyan, Hill, W. David, Homuth, Georg, Horta, Bernando Lessa, Huang, Hongyang, Hyppӧnen, Elina, Ikram, M. Arfan, Johannesson, Magnus, Kamali, Zoha, Kavousi, Maryam, Kraft, Peter, Kühnel, Brigitte, Langenberg, Claudia, Lind, Penelope A., Luan, Jian’an, Mägi, Reedik, Magnusson, Patrik K. E., Mahajan, Anubha, Martin, Nicholas G., Mbarek, Hamdi, McCarthy, Mark I., McMahon, George, McQueen, Matthew B., Medland, Sarah E., Meitinger, Thomas, Metspalu, Andres, Mihailov, Evelin, Missmer, Stacey A., Møllegaard, Stine, Mook-Kanamori, Dennis O., Morgan, Anna, van der Most, Peter J., de Mutsert, Renée, Nolte, Ilja M., Noordam, Raymond, Peters, Annette, Power, Chris, Redmond, Paul, Rich-Edwards, Janet W., Ridker, Paul M., Rietveld, Cornelius A., Ring, Susan M., Rose, Lynda M., Rueedi, Rico, Stefánsson, Kári, Stöckl, Doris, Strauch, Konstantin, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Thurik, A. Roy, Timpson, Nicholas J., Turman, Constance, Waldenberger, Melanie, Wareham, Nicholas J., Willemsen, Gonneke, Zhao, Jing Hau, Pers, Tune H., Snieder, Harold, Perry, John R. B., Ong, Ken K., den Hoed, Marcel, Barban, Nicola, Day, Felix R.

Publikováno v: Nature Human Behaviour, 5, 1717-1730. Nature Publishing Group
Nature human behaviour
eQTLGen Consortium, BIOS Consortium & Human Reproductive Behaviour Consortium 2021, ' Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour ', Nature Human Behaviour, vol. 5, pp. 1717-1730 . https://doi.org/10.1038/s41562-021-01135-3
2021, ' Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour ', Nature Human Behaviour, vol. 5, no. 12, pp. 1717–1730 . https://doi.org/10.1038/s41562-021-01135-3
Nat. Hum. Behav. 5, 1717-1730 (2021)
Mills, M C, Boomsma, D I, Jansen, R, Nivard, M G, van Dongen, J, de Geus, E J C, Jan Hottenga, J, Mbarek, H, Willemsen, G & eQTLGen Consortium 2021, ' Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour ', Nature Human Behaviour, vol. 5, no. 12, pp. 1717-1730 . https://doi.org/10.1038/s41562-021-01135-3
Nature Human Behaviour, 5(12), 1717-1730. Springer Nature
Nature Human Behaviour. Nature Publishing Group
Nature Human Behaviour, 5(12), 1717-1730. Nature Publishing Group
Nature Human Behaviour

Age at first sexual intercourse and age at first birth have implications for health and evolutionary fitness. In this genome-wide association study (age at first sexual intercourse, N = 387,338; age at first birth, N = 542,901), we identify 371 singl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d336f359b5ba96201fa273a5a01c10fb
https://doi.org/10.1038/s41562-021-01135-3

DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan

Autor: van Dongen, Jenny, Hagenbeek, Fiona A., Suderman, Matthew, Roetman, Peter J., Sugden, Karen, Chiocchetti, Andreas G., Ismail, Khadeeja, Mulder, Rosa H., Hafferty, Jonathan D., Adams, Mark J., Walker, Rosie M., Morris, Stewart W., Lahti, Jari, Küpers, Leanne K., Escaramis, Georgia, Alemany, Silvia, Jan Bonder, Marc, Meijer, Mandy, Ip, Hill F., Jansen, Rick, Baselmans, Bart M. L., Parmar, Priyanka, Lowry, Estelle, Streit, Fabian, Sirignano, Lea, Send, Tabea S., Frank, Josef, Jylhävä, Juulia, Wang, Yunzhang, Mishra, Pashupati Prasad, Colins, Olivier F., Corcoran, David L., Poulton, Richie, Mill, Jonathan, Hannon, Eilis, Arseneault, Louise, Korhonen, Tellervo, Vuoksimaa, Eero, Felix, Janine F., Bakermans-Kranenburg, Marian J., Campbell, Archie, Czamara, Darina, Binder, Elisabeth, Corpeleijn, Eva, Gonzalez, Juan R., Grazuleviciene, Regina, Gutzkow, Kristine B., Evandt, Jorunn, Vafeiadi, Marina, Klein, Marieke, van der Meer, Dennis, Ligthart, Lannie, Heijmans, Bastiaan T., ’t Hoen, Peter A. C., van Meurs, Joyce, Franke, Lude, Boomsma, Dorret I., Pool, René, Hottenga, Jouke J., van Greevenbroek, Marleen M. J., Stehouwer, Coen D. A., van der Kallen, Carla J. H., Schalkwijk, Casper G., Wijmenga, Cisca, Zhernakova, Sasha, Tigchelaar, Ettje F., Slagboom, P. Eline, Beekman, Marian, Deelen, Joris, van Heemst, Diana, Veldink, Jan H., van den Berg, Leonard H., van Duijn, Cornelia M., Hofman, Bert A., Isaacs, Aaron, Uitterlinden, André G., Jhamai, P. Mila, Verbiest, Michael, Suchiman, H. Eka D., Verkerk, Marijn, van der Breggen, Ruud, van Rooij, Jeroen, Lakenberg, Nico, Mei, Hailiang, van Iterson, Maarten, van Galen, Michiel, Bot, Jan, Zhernakova, Dasha V., van ’t Hof, Peter, Deelen, Patrick, Nooren, Irene, Moed, Matthijs, Vermaat, Martijn, Luijk, René, van Dijk, Freerk, Arindrarto, Wibowo, Kielbasa, Szymon M., Swertz, Morris A., van Zwet, Erik. W., ’t Hoen, Peter-Bram, Kluft, Cornelis, Davies, Gareth E., Hakulinen, Christian, Keltikangas-Järvinen, Liisa, Franke, Barbara, Freitag, Christine M., Konrad, Kerstin, Hervas, Amaia, Fernández-Rivas, Aranzazu, Vetro, Agnes, Raitakari, Olli, Lehtimäki, Terho, Vermeiren, Robert, Strandberg, Timo, Räikkönen, Katri, Snieder, Harold, Witt, Stephanie H., Deuschle, Michael, Pedersen, Nancy L., Hägg, Sara, Sunyer, Jordi, Kaprio, Jaakko, Ollikainen, Miina, Moffitt, Terrie E., Tiemeier, Henning, van IJzendoorn, Marinus H., Relton, Caroline, Vrijheid, Martine, Sebert, Sylvain, Jarvelin, Marjo-Riitta, Caspi, Avshalom, Evans, Kathryn L., McIntosh, Andrew M., Bartels, Meike

Publikováno v: Molecular Psychiatry. Nature Publishing Group
Molecular psychiatry 26(6), 2148-2162 (2021). doi:10.1038/s41380-020-00987-x
Molecular Psychiatry
Molecular Psychiatry, 26, 2148-2162. Nature Publishing Group
Molecular Psychiatry, 26, 2148-2162
Molecular Psychiatry, 26, 6, pp. 2148-2162
Molecular Psychiatry, 26(6), 2148-2162. Nature Publishing Group
BIOS Consortium 2021, ' DNA methylation signatures of aggression and closely related constructs : A meta-analysis of epigenome-wide studies across the lifespan ', Molecular Psychiatry, vol. 26, pp. 2148-2162 . https://doi.org/10.1038/s41380-020-00987-x
BIOS Consortium 2021, ' DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan ', Molecular Psychiatry . https://doi.org/10.1038/s41380-020-00987-x
van~Dongen, J, Arseneault, L, Moffitt, T, Caspi, A & Boomsma, D I 2021, ' DNA methylation signatures of aggression and closely related constructs : A meta-analysis of epigenome-wide studies across the lifespan ', Molecular Psychiatry . https://doi.org/10.1038/s41380-020-00987-x
van Dongen, J, Relton, C L, Hagenbeek, F & Suderman, M J 2021, ' DNA methylation signatures of aggression and closely related constructs : A meta-analysis of epigenome-wide studies across the lifespan ', Molecular Psychiatry, vol. (2021) . https://doi.org/10.1038/s41380-020-00987-x
Molecular Psychiatry, 26(6), 2148-2162. SPRINGERNATURE
2021, ' DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan ', Molecular Psychiatry . https://doi.org/10.1038/s41380-020-00987-x
van Dongen, J, Hagenbeek, F A, Suderman, M, Roetman, P J, Sugden, K, Chiocchetti, A G, Ismail, K, Mulder, R H, Hafferty, J D, Adams, M J, Walker, R M, Morris, S W, Lahti, J, Küpers, L K, Escaramis, G, Alemany, S, Jan Bonder, M, Meijer, M, Ip, H F, Jansen, R, Baselmans, B M L, Parmar, P, Lowry, E, Streit, F, Sirignano, L, Send, T S, Frank, J, Jylhävä, J, Wang, Y, Mishra, P P, Colins, O F, Corcoran, D L, Poulton, R, Mill, J, Hannon, E, Arseneault, L, Korhonen, T, Vuoksimaa, E, Felix, J F, Bakermans-kranenburg, M J, Campbell, A, Czamara, D, Binder, E, Corpeleijn, E, Gonzalez, J R, Grazuleviciene, R, Gutzkow, K B, Evandt, J, Vafeiadi, M, Klein, M, Van Der Meer, D, Ligthart, L, Kluft, C, Davies, G E, Hakulinen, C, Keltikangas-järvinen, L, Franke, B, Freitag, C M, Konrad, K, Hervas, A, Fernández-rivas, A, Vetro, A, Raitakari, O, Lehtimäki, T, Vermeiren, R, Strandberg, T, Räikkönen, K, Snieder, H, Witt, S H, Deuschle, M, Pedersen, N L, Hägg, S, Sunyer, J, Franke, L, Kaprio, J, Ollikainen, M, Moffitt, T E, Tiemeier, H, Van Ijzendoorn, M H, Relton, C, Vrijheid, M, Sebert, S, Jarvelin, M, Caspi, A, Evans, K L, Mcintosh, A M, Bartels, M & Boomsma, D I 2021, ' DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan ', Molecular Psychiatry, vol. 26, no. 6, pp. 2148-2162 . https://doi.org/10.1038/s41380-020-00987-x

Molecular psychiatry 26(6), 2148-2162 (2021). doi:10.1038/s41380-020-00987-x
Published by Macmillan, London

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e721614c28e4240bb31a02dbb0cc9802
https://pure.eur.nl/en/publications/03bda168-c58f-4f40-862c-db6532c2d867

A linear mixed-model approach to study multivariate gene–environment interactions

Autor: 't Hoen, P.A., van Meurs, Joyce B J, Isaacs, Aaron, Jansen, Rick, Franke, Lude, Boomsma, D.I., Pool, R., van Dongen, J., Hottenga, J.J., Van Greevenbroek, Marleen J., Stehouwer, Coen D A, van der Kallen, Carla J H, Schalkwijk, Casper G, Wijmenga, Cisca, Zhernakova, Alexandra, Tigchelaar, Ettje F, Slagboom, P. Eline, Beekman, Marian, Deelen, Joris, van Heemst, Diana, Veldink, Jan H, van den Berg, Leonard H, van Duijn, Cornelia M, Hofman, Bert A., Uitterlinden, Andre G, Jhamai, P Mila, Verbiest, Michael, Suchiman, H. Eka D., Verkerk, Marijn, van der Breggen, Ruud, van Rooij, Jeroen, Lakenberg, Nico, Mei, Hailiang, van Iterson, Maarten, van Galen, Michiel, Bot, Jan, van’t Hof, Peter, Deelen, Patrick, Nooren, Irene, Moed, Matthijs, Vermaat, Martijn, Zhernakova, Dasha V., Luijk, René, Jan Bonder, Marc, van Dijk, Freerk, Arindrarto, Wibowo, Kielbasa, P. Szymon M., Swertz, Morris a., van Zwet, Erik W

Publikováno v: Moore, R, Casale, F P, Jan Bonder, M, Horta, D, Franke, L, Barroso, I, Stegle, O & BIOS Consortium 2019, ' A linear mixed-model approach to study multivariate gene–environment interactions ', Nature Genetics, vol. 51, no. 1, pp. 180-186 . https://doi.org/10.1038/s41588-018-0271-0
Nature Genetics, 51(1), 180-186. Nature Publishing Group
't Hoen, P A, van Meurs, J B J, Isaacs, A, Jansen, R, Franke, L, Boomsma, D I, Pool, R, van Dongen, J, Hottenga, J J, Van Greevenbroek, M J, Stehouwer, C D A, van der Kallen, C J H, Schalkwijk, C G, Wijmenga, C, Zhernakova, A, Tigchelaar, E F, Slagboom, P E, Beekman, M, Deelen, J, van Heemst, D, Veldink, J H, van den Berg, L H, van Duijn, C M, Hofman, B A, Uitterlinden, A G, Jhamai, P M, Verbiest, M, Suchiman, H E D, Verkerk, M, van der Breggen, R, van Rooij, J, Lakenberg, N, Mei, H, van Iterson, M, van Galen, M, Bot, J, van’t Hof, P, Deelen, P, Nooren, I, Moed, M, Vermaat, M, Zhernakova, D V, Luijk, R, Jan Bonder, M, van Dijk, F, Arindrarto, W, Kielbasa, P S M, Swertz, M A, van Zwet, E W & BIOS Consortium 2019, ' A linear mixed-model approach to study multivariate gene-environment interactions ', Nature Genetics, vol. 51, no. 1, pp. 180-186 . https://doi.org/10.1038/s41588-018-0271-0

Different environmental factors, including diet, physical activity, or external conditions can contribute to genotype-environment interactions (GxE). Although high-dimensional environmental data are increasingly available, and multiple environments h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::329339e0424884e7221abf5b507b437e
https://research.vumc.nl/en/publications/bc3d6aef-b18e-4156-b939-0c5e6c101469