Water in peripheral TM-interfaces of Orai1-channels triggers pore opening.

Autor: Hopl, Valentina¹ (AUTHOR), Tiffner, Adéla^1,2 (AUTHOR), Wutscher, Armin¹ (AUTHOR), Sallinger, Matthias¹ (AUTHOR), Grabmayr, Herwig¹ (AUTHOR), Prantl, Magdalena¹ (AUTHOR), Fröhlich, Maximilian¹ (AUTHOR), Söllner, Julia¹ (AUTHOR), Weiß, Sarah¹ (AUTHOR), Najjar, Hadil¹ (AUTHOR), Nazarenko, Yuliia¹ (AUTHOR), Harant, Selina¹ (AUTHOR), Kriško, Natalia¹ (AUTHOR), Fahrner, Marc¹ (AUTHOR), Humer, Christina¹ (AUTHOR), Höglinger, Carmen¹ (AUTHOR), Krobath, Heinrich³ (AUTHOR), Bonhenry, Daniel⁴ (AUTHOR) daniel.bonhenry@gmail.com, Derler, Isabella¹ (AUTHOR) isabella.derler@jku.at

Publikováno v: Communications Biology. 11/16/2024, Vol. 7 Issue 1, p1-16. 16p.

Photocrosslinking-induced CRAC channel-like Orai1 activation independent of STIM1

Autor: Lena Maltan, Sarah Weiß, Hadil Najjar, Melanie Leopold, Sonja Lindinger, Carmen Höglinger, Lorenz Höbarth, Matthias Sallinger, Herwig Grabmayr, Sascha Berlansky, Denis Krivic, Valentina Hopl, Anna Blaimschein, Marc Fahrner, Irene Frischauf, Adéla Tiffner, Isabella Derler

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)

The Ca2+ ion channel Orai1 is crucial in immune cells. Here, the authors applied genetic code expansion to transfer light-sensitivity to the Orai1 channel and achieved precise control over its function.

Externí odkaz: https://doaj.org/article/bee2dd102ac04d1e8838711cbc3c5162

Dermal open flow microperfusion for PK-based clinical bioequivalence studies of topical drug products

Autor: Thomas Birngruber, Katrin I. Tiffner, Selma I. Mautner, Frank M. Sinner

Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)

Topically applied drug products have experienced an extraordinary price increase in the United States, mostly due to a lack of generic products. Generic drug development is hindered by high costs and risks associated with clinical endpoint studies re

Externí odkaz: https://doaj.org/article/98c2ac868a6f470eb6456f5aa1cbc1d5

CRAC and SK Channels: Their Molecular Mechanisms Associated with Cancer Cell Development.

Autor: Tiffner, Adéla¹ (AUTHOR) adela.tiffner@jku.at, Hopl, Valentina¹ (AUTHOR), Derler, Isabella¹ (AUTHOR) adela.tiffner@jku.at

Publikováno v: Cancers. Jan2023, Vol. 15 Issue 1, p101. 49p.

Deciphering Molecular Mechanisms and Intervening in Physiological and Pathophysiological Processes of Ca2+ Signaling Mechanisms Using Optogenetic Tools

Autor: Lena Maltan, Hadil Najjar, Adéla Tiffner, Isabella Derler

Publikováno v: Cells, Vol 10, Iss 12, p 3340 (2021)

Calcium ion channels are involved in numerous biological functions such as lymphocyte activation, muscle contraction, neurotransmission, excitation, hormone secretion, gene expression, cell migration, memory, and aging. Therefore, their dysfunction c

Externí odkaz: https://doaj.org/article/271a54eae7c64612b872563aa6dec883