Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Tiffany W. Todd"'
Autor:
Karen Jansen-West, Tiffany W. Todd, Lillian M. Daughrity, Mei Yue, Jimei Tong, Yari Carlomagno, Giulia Del Rosso, Aishe Kurti, Caroline Y. Jones, Judith A. Dunmore, Monica Castanedes-Casey, Dennis W. Dickson, Zbigniew K. Wszolek, John D. Fryer, Leonard Petrucelli, Mercedes Prudencio
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Spinocerebellar ataxia type 3 (SCA3) is a dominantly inherited cerebellar ataxia caused by the expansion of a polyglutamine (polyQ) repeat in the gene encoding ATXN3. The polyQ expansion induces protein inclusion formation in the neurons of patients
Externí odkaz:
https://doaj.org/article/93c536b37c164026a09cc9898bc89801
Autor:
Giulia del Rosso, Yari Carlomagno, Tiffany W. Todd, Caroline Y. Jones, Mercedes Prudencio, Lillian M. Daughrity, Mei Yue, Karen Jansen-West, Jimei Tong, Wei Shao, Yanwei Wu, Monica Castanedes-Casey, Lilia Tabassian, Björn Oskarsson, Karen Ling, Frank Rigo, Dennis W. Dickson, Tso-Pang Yao, Leonard Petrucelli, Casey N. Cook, Yong Jie Zhang
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2022)
The aberrant translation of a repeat expansion in chromosome 9 open reading frame 72 (C9orf72), the most common cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), results in the accumulation of toxic dipeptide repeat (DPR
Externí odkaz:
https://doaj.org/article/82dcc1ca691c4a8c903043790d6753ad
Autor:
Yanwei Wu, Wei Shao, Tiffany W. Todd, Jimei Tong, Mei Yue, Shunsuke Koga, Monica Castanedes-Casey, Ariston L. Librero, Chris W. Lee, Ian R. Mackenzie, Dennis W. Dickson, Yong-Jie Zhang, Leonard Petrucelli, Mercedes Prudencio
Publikováno v:
Cell Reports, Vol 36, Iss 8, Pp 109581- (2021)
Summary: Loss-of-function mutations in the progranulin gene (GRN), which encodes progranulin (PGRN), are a major cause of frontotemporal dementia (FTD). GRN-associated FTD is characterized by TDP-43 inclusions and neuroinflammation, but how PGRN loss
Externí odkaz:
https://doaj.org/article/3f8cecd7c2684fee95aea210a86e2903
Autor:
Tiffany W. Todd, Zachary T. McEachin, Jeannie Chew, Alexander R. Burch, Karen Jansen-West, Jimei Tong, Mei Yue, Yuping Song, Monica Castanedes-Casey, Aishe Kurti, Judith H. Dunmore, John D. Fryer, Yong-Jie Zhang, Beatriz San Millan, Susana Teijeira Bautista, Manuel Arias, Dennis Dickson, Tania F. Gendron, María-Jesús Sobrido, Matthew D. Disney, Gary J. Bassell, Wilfried Rossoll, Leonard Petrucelli
Publikováno v:
Cell Reports, Vol 31, Iss 5, Pp - (2020)
Summary: A G4C2 hexanucleotide repeat expansion in an intron of C9orf72 is the most common cause of frontal temporal dementia and amyotrophic lateral sclerosis (c9FTD/ALS). A remarkably similar intronic TG3C2 repeat expansion is associated with spino
Externí odkaz:
https://doaj.org/article/a1385bc8f994442d9c1094bb8a16c0d4
Autor:
Paula Castellanos Otero, Tiffany W Todd, Wei Shao, Caroline J Jones, Kexin Huang, Lillian M Daughrity, Mei Yue, Udit Sheth, Tania F Gendron, Mercedes Prudencio, Björn Oskarsson, Dennis W Dickson, Leonard Petrucelli, Yong-Jie Zhang
Publikováno v:
PLoS ONE, Vol 19, Iss 4, p e0298080 (2024)
Inclusions containing TAR DNA binding protein 43 (TDP-43) are a pathological hallmark of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). One of the disease-specific features of TDP-43 inclusions is the aberrant phosphorylation
Externí odkaz:
https://doaj.org/article/8a84232f980c4c2ab3c974b7c2363957
Autor:
Wei Shao, Tiffany W. Todd, Yanwei Wu, Caroline Y. Jones, Jimei Tong, Karen Jansen-West, Lillian M. Daughrity, Jinyoung Park, Yuka Koike, Aishe Kurti, Mei Yue, Monica Castanedes-Casey, Giulia del Rosso, Judith A. Dunmore, Desiree Zanetti Alepuz, Björn Oskarsson, Dennis W. Dickson, Casey N. Cook, Mercedes Prudencio, Tania F. Gendron, John D. Fryer, Yong-Jie Zhang, Leonard Petrucelli
Publikováno v:
Science. 378:94-99
Frontotemporal dementia and amyotrophic lateral sclerosis (FTD-ALS) are associated with both a repeat expansion in the C9orf72 gene and mutations in the TANK-binding kinase 1 ( TBK1 ) gene. We found that TBK1 is phosphorylated in response to C9orf72
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28515e918d894676744deafbd4c2c0b0
https://doi.org/10.1126/science.abq7860
https://doi.org/10.1126/science.abq7860
Autor:
Tiffany W. Todd, Leonard Petrucelli
Publikováno v:
Nature Reviews Neuroscience. 23:231-251
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9e85d47d36da9fdffa3fed1837e0d3b
https://doi.org/10.1038/s41583-022-00564-x
https://doi.org/10.1038/s41583-022-00564-x
Autor:
Tiffany W. Todd, Leonard Petrucelli
Publikováno v:
Nature Reviews Neurology. 18:189-190
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd55609ebfe25e4e970ffa725adbf185
https://doi.org/10.1038/s41582-022-00629-6
https://doi.org/10.1038/s41582-022-00629-6
Autor:
Tiffany W. Todd, Yuping Song, Wilfried Rossoll, Susana Teijeira Bautista, María Jesús Sobrido, Yong Jie Zhang, Monica Castanedes-Casey, Gary J. Bassell, Alexander R. Burch, Matthew D. Disney, Karen Jansen-West, Beatriz San Millán, Jimei Tong, Manuel Arias, Jeannie Chew, John D. Fryer, Judith Dunmore, Leonard Petrucelli, Mei Yue, Tania F. Gendron, Aishe Kurti, Zachary T. McEachin, Dennis W. Dickson
Publikováno v:
Cell Rep
Cell Reports, Vol 31, Iss 5, Pp-(2020)
Cell Reports, Vol 31, Iss 5, Pp-(2020)
A G(4)C(2) hexanucleotide repeat expansion in an intron of C9orf72 is the most common cause of frontal temporal dementia and amyotrophic lateral sclerosis (c9FTD/ALS). A remarkably similar intronic TG(3)C(2) repeat expansion is associated with spinoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f315aa6ae3c41dccf4c15d47469833c4
https://pubmed.ncbi.nlm.nih.gov/32375043
https://pubmed.ncbi.nlm.nih.gov/32375043
Autor:
Beatriz San Millán, Nathalie Streichenberger, Patricia J. Ward, Megan E. Merritt-Garza, Karen Jansen-West, Malú G. Tansey, Nisha Raj, Gary J. Bassell, Christopher J. Holler, María García-Murias, Leonard Petrucelli, Zhexing Wen, Koji Abe, Susana Teijeira, Jonathan D. Glass, Chongchong Xu, Anwesha Banerjee, Thomas Kukar, Brent L. Fogel, Nicholas M. Boulis, Manuel Arias, Jie Jiang, Dennis W. Dickson, Tania F. Gendron, Beatriz Quintáns, Tiffany W. Todd, María-Jesús Sobrido, Georgia Taylor, Toru Yamashita, Zachary T. McEachin, Tania García-Sobrino, Ryuichi Ohkubo, Wilfried Rossoll, Ryan H. Purcell, Chadwick M. Hales
Publikováno v:
Neuron
GGGGCC hexanucleotide repeat expansions (HREs) in C9orf72 cause amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) and lead to the production of aggregating dipeptide repeat proteins (DPRs) via repeat associated non-AUG (RAN) trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::070a561150b07089e24faf951de251ea
https://pubmed.ncbi.nlm.nih.gov/32702342
https://pubmed.ncbi.nlm.nih.gov/32702342