Zobrazeno 1 - 10 of 27 pro vyhledávání: '"Tiffany W. Todd"'
1
Akademický článek
Generation and characterization of monoclonal antibodies against pathologically phosphorylated TDP-43.
Autor: Paula Castellanos Otero, Tiffany W Todd, Wei Shao, Caroline J Jones, Kexin Huang, Lillian M Daughrity, Mei Yue, Udit Sheth, Tania F Gendron, Mercedes Prudencio, Björn Oskarsson, Dennis W Dickson, Leonard Petrucelli, Yong-Jie Zhang
Publikováno v: PLoS ONE, Vol 19, Iss 4, p e0298080 (2024)
Inclusions containing TAR DNA binding protein 43 (TDP-43) are a pathological hallmark of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). One of the disease-specific features of TDP-43 inclusions is the aberrant phosphorylation
Externí odkaz: https://doaj.org/article/8a84232f980c4c2ab3c974b7c2363957
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2
Akademický článek
Plasma PolyQ-ATXN3 Levels Associate With Cerebellar Degeneration and Behavioral Abnormalities in a New AAV-Based SCA3 Mouse Model
Autor: Karen Jansen-West, Tiffany W. Todd, Lillian M. Daughrity, Mei Yue, Jimei Tong, Yari Carlomagno, Giulia Del Rosso, Aishe Kurti, Caroline Y. Jones, Judith A. Dunmore, Monica Castanedes-Casey, Dennis W. Dickson, Zbigniew K. Wszolek, John D. Fryer, Leonard Petrucelli, Mercedes Prudencio
Publikováno v: Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Spinocerebellar ataxia type 3 (SCA3) is a dominantly inherited cerebellar ataxia caused by the expansion of a polyglutamine (polyQ) repeat in the gene encoding ATXN3. The polyQ expansion induces protein inclusion formation in the neurons of patients
Externí odkaz: https://doaj.org/article/93c536b37c164026a09cc9898bc89801
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3
Akademický článek
HDAC6 Interacts With Poly (GA) and Modulates its Accumulation in c9FTD/ALS
Autor: Giulia del Rosso, Yari Carlomagno, Tiffany W. Todd, Caroline Y. Jones, Mercedes Prudencio, Lillian M. Daughrity, Mei Yue, Karen Jansen-West, Jimei Tong, Wei Shao, Yanwei Wu, Monica Castanedes-Casey, Lilia Tabassian, Björn Oskarsson, Karen Ling, Frank Rigo, Dennis W. Dickson, Tso-Pang Yao, Leonard Petrucelli, Casey N. Cook, Yong Jie Zhang
Publikováno v: Frontiers in Cell and Developmental Biology, Vol 9 (2022)
The aberrant translation of a repeat expansion in chromosome 9 open reading frame 72 (C9orf72), the most common cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), results in the accumulation of toxic dipeptide repeat (DPR
Externí odkaz: https://doaj.org/article/82dcc1ca691c4a8c903043790d6753ad
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4
Akademický článek
Microglial lysosome dysfunction contributes to white matter pathology and TDP-43 proteinopathy in GRN-associated FTD
Autor: Yanwei Wu, Wei Shao, Tiffany W. Todd, Jimei Tong, Mei Yue, Shunsuke Koga, Monica Castanedes-Casey, Ariston L. Librero, Chris W. Lee, Ian R. Mackenzie, Dennis W. Dickson, Yong-Jie Zhang, Leonard Petrucelli, Mercedes Prudencio
Publikováno v: Cell Reports, Vol 36, Iss 8, Pp 109581- (2021)
Summary: Loss-of-function mutations in the progranulin gene (GRN), which encodes progranulin (PGRN), are a major cause of frontotemporal dementia (FTD). GRN-associated FTD is characterized by TDP-43 inclusions and neuroinflammation, but how PGRN loss
Externí odkaz: https://doaj.org/article/3f8cecd7c2684fee95aea210a86e2903
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5
Akademický článek
Hexanucleotide Repeat Expansions in c9FTD/ALS and SCA36 Confer Selective Patterns of Neurodegeneration In Vivo
Autor: Tiffany W. Todd, Zachary T. McEachin, Jeannie Chew, Alexander R. Burch, Karen Jansen-West, Jimei Tong, Mei Yue, Yuping Song, Monica Castanedes-Casey, Aishe Kurti, Judith H. Dunmore, John D. Fryer, Yong-Jie Zhang, Beatriz San Millan, Susana Teijeira Bautista, Manuel Arias, Dennis Dickson, Tania F. Gendron, María-Jesús Sobrido, Matthew D. Disney, Gary J. Bassell, Wilfried Rossoll, Leonard Petrucelli
Publikováno v: Cell Reports, Vol 31, Iss 5, Pp - (2020)
Summary: A G4C2 hexanucleotide repeat expansion in an intron of C9orf72 is the most common cause of frontal temporal dementia and amyotrophic lateral sclerosis (c9FTD/ALS). A remarkably similar intronic TG3C2 repeat expansion is associated with spino
Externí odkaz: https://doaj.org/article/a1385bc8f994442d9c1094bb8a16c0d4
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8
Akademický článek
Nemo-like kinase is a novel regulator of spinal and bulbar muscular atrophy
Autor: Tiffany W Todd, Hiroshi Kokubu, Helen C Miranda, Constanza J Cortes, Albert R La Spada, Janghoo Lim
Publikováno v: eLife, Vol 4 (2015)
Spinal and bulbar muscular atrophy (SBMA) is a progressive neuromuscular disease caused by polyglutamine expansion in the androgen receptor (AR) protein. Despite extensive research, the exact pathogenic mechanisms underlying SBMA remain elusive. In t
Externí odkaz: https://doaj.org/article/cc43d13fc78744b6a1f713f365da0625
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