Výsledky vyhledávání - "Tiffany Sergent"

The Heparin Binding Domain of Vitronectin Is the Region that Is Required to Enhance Insulin-Like Growth Factor-I Signaling

Autor: Walker H. Busby, Kevin Sitko, Byron E. Capps, Yan Ling, David R. Clemmons, Jane Badley-Clarke, Tiffany Sergent, Laura A. Maile

Publikováno v: Molecular Endocrinology. 20:881-892

We have shown that vitronectin (Vn) binding to a cysteine loop sequence within the extracellular domain of the beta3-subunit (amino acids 177-184) of alphaVbeta3 is required for the positive effects of Vn on IGF-I signaling. When Vn binding to this s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7506f712413cb4291885980d40345f8
https://doi.org/10.1210/me.2005-0382

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Insulin-like growth factor-I signaling in smooth muscle cells is regulated by ligand binding to the 177CYDMKTTC184 sequence of the beta3-subunit of alphaVbeta3

Autor: Kevin Sitko, Byron E. Capps, Walker H. Busby, Tiffany Sergent, Laura A. Maile, Jane Badley-Clarke, David R. Clemmons

Publikováno v: Molecular endocrinology (Baltimore, Md.). 20(2)

The response of smooth muscle cells to IGF-I requires ligand occupancy of the alphaVbeta3 integrin. We have shown that vitronectin (Vn) is required for IGF-I-stimulated migration or proliferation, whereas the anti-alphaVbeta3 monoclonal antibody, LM6

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b33845bcf4969bc4e98ea056ce194f26
https://pubmed.ncbi.nlm.nih.gov/16195248

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