Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Tiffany N. Seagroves"'
Autor:
Aarti Sethuraman, Martin Brown, Raya Krutilina, Zhao-Hui Wu, Tiffany N. Seagroves, Lawrence M. Pfeffer, Meiyun Fan
Publikováno v:
Breast Cancer Research, Vol 20, Iss 1, Pp 1-17 (2018)
Abstract Background Metastasis is responsible for a significant number of breast cancer-related deaths. Hypoxia, a primary driving force of cancer metastasis, induces the expression of BHLHE40, a transcription regulator. This study aimed to elucidate
Externí odkaz:
https://doaj.org/article/988b28cb573942f08a89ec7b374d82d1
Autor:
Amy R Dwyer, Carlos Perez Kerkvliet, Thu H Truong, Kyla M Hagen, Raisa I Krutilina, Deanna N Parke, Robert H Oakley, Christopher Liddle, John A Cidlowski, Tiffany N Seagroves, Carol A Lange
Publikováno v:
Endocrinology.
Corticosteroids act on the glucocorticoid receptor (GR; NR3C1) to resolve inflammation and are routinely prescribed to breast cancer patients undergoing chemotherapy treatment to alleviate side effects. Triple negative breast cancers (TNBCs) account
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de70e0a8a180e0c1fdd967333273d4aa
https://doi.org/10.1210/endocr/bqad083
https://doi.org/10.1210/endocr/bqad083
PDF file - 292K, Supplementary Figure 1: Structure of DPM and H&E-stained end stage tumor sections. Supplementary Figure 2: No gross changes in cellular proliferation, apoptosis or microvessel density are observed in end stage tumors in response to D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::253cfc799b3bd492c46aa6b08b638d5b
https://doi.org/10.1158/1940-6207.22523236
https://doi.org/10.1158/1940-6207.22523236
Autor:
Carol A. Lange, Tiffany N. Seagroves, Kathryn L. Schwertfeger, Julie H. Ostrander, John A. Cidlowski, Ganesh V. Raj, Raisa I. Krutilina, Taylor M. Helle, Yan Peng, Carlos Perez Kerkvliet, Shihong Ma, Tarah M. Regan Anderson
Western blot of MDA-MB-231 parental or HIF DKO cells demonstrating loss of regulation of PELP1 expression in response to taxol treatment in cells with HIF double-knockout.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::018a32d865189c97f4ef83ef8af040be
https://doi.org/10.1158/1541-7786.22511061.v1
https://doi.org/10.1158/1541-7786.22511061.v1
PDF file - 119K, Table 1A. Genes enriched as over-expressed in DPM treatment group Table 1B. Genes enriched as under-expressed in DPM treatment group Table 2A. Functional enrichment (based on GO Biological Process) of genes over-expressed in DPM trea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95b350990dbe500f1435ffd961aeb3a7
https://doi.org/10.1158/1940-6207.22523230
https://doi.org/10.1158/1940-6207.22523230
Autor:
Wei Li, Tiffany N. Seagroves, Duane D. Miller, Hao Chen, Hilaire C. Playa, Deanna N. Parke, Zongtao Lin, Qinghui Wang, Raisa I. Krutilina, Shanshan Deng
Figure S4 shows that FACS analysis profiles of MDA-MB-231 and MDA-MB-468 TNBC cells following treatment with vehicle (Control), colchicine or paclitaxel, showing VERU-111 induces G2/M checkpoint arrest and apoptosis in TNBC cells. (A) Representative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4abbf7e6fa32c353eb37d21ea549a635
https://doi.org/10.1158/1535-7163.22521088.v1
https://doi.org/10.1158/1535-7163.22521088.v1
Autor:
Carol A. Lange, Tiffany N. Seagroves, Branden S. Moriarity, Branden A. Smeester, Warner A. Thomas, Deanna N. Parke, Hilaire C. Playa, Raisa I. Krutilina, Carlos Perez Kerkvliet, Amy R. Dwyer
Protein tyrosine kinase 6 (PTK6; also called Brk) is overexpressed in 86% of patients with breast cancer; high PTK6 expression predicts poor outcome. We reported PTK6 induction by HIF/GR complexes in response to either cellular or host stress. Howeve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69d0304fb51326066012a9b3ba80d995
https://doi.org/10.1158/1541-7786.c.6545328.v1
https://doi.org/10.1158/1541-7786.c.6545328.v1
Autor:
Wei Li, Duane D. Miller, Tiffany N. Seagroves, Bernd Meibohm, Pradeep B. Lukka, Dejian Ma, Foyez Mahmud, Rui Wang, Deanna N. Parke, Hao Chen, Kelli L. Hartman, Raisa I. Krutilina, Shanshan Deng
Supplementary Data from Colchicine-Binding Site Agent CH-2-77 as a Potent Tubulin Inhibitor Suppressing Triple-Negative Breast Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f3f5a0f2dc3cc685e997464eb825751
https://doi.org/10.1158/1535-7163.22523883.v1
https://doi.org/10.1158/1535-7163.22523883.v1
Autor:
Carol A. Lange, Tiffany N. Seagroves, Kathryn L. Schwertfeger, Julie H. Ostrander, John A. Cidlowski, Ganesh V. Raj, Raisa I. Krutilina, Taylor M. Helle, Yan Peng, Carlos Perez Kerkvliet, Shihong Ma, Tarah M. Regan Anderson
Western blot and qPCR data of MDA-MB-231 cells treated for 0-5 days with 5FU, showing increased Brk, HIF-1a, and HIF-2a in response to 5FU.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00825fe1412faa9277ebe63bf4227735
https://doi.org/10.1158/1541-7786.22511064.v1
https://doi.org/10.1158/1541-7786.22511064.v1
Autor:
Wei Li, Tiffany N. Seagroves, Duane D. Miller, Hao Chen, Hilaire C. Playa, Deanna N. Parke, Zongtao Lin, Qinghui Wang, Raisa I. Krutilina, Shanshan Deng
Table S1 shows anti-proliferating effects of VERU-111 against various human cancer cell lines (mean {plus minus} SEM, n = 4 biological replicate experiments).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30a6289862d8a507f29a570bfcd26edd
https://doi.org/10.1158/1535-7163.22521079.v1
https://doi.org/10.1158/1535-7163.22521079.v1