Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Tiffany N. Hoerter"'
Autor:
Michael W. Wood, Dean G. Brown, Shephali Trivedi, Don Mathisen, Mark Sylvester, Xia Wang, John C. Roberts, Zuozhong Peng, Tao Hu, Tiffany N. Hoerter, Magnus Johansson, Donna L. Maier, Tongming Chen, Jennifer R. Krumrine, Ji Jiang, Carla Maciag, Lee T. Hirata, Celina C. Lasota, Anshul Gupta, Deidre E. Wilkins, Frank Liu, Jian Xia, Charles S. Elmore, Evelynjeane J. Sutton, Xiaoping Wang, James B. Campbell, Jerry Cumberledge, Cristobal Alhambra, Dennis J. McCarthy, Elnaz Menhaji-Klotz, Jian Wang, Xiaotian Wen, Paul J. Ciaccio, Clay W Scott
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:3399-3403
Herein we describe the discovery of compounds that are competitive antagonists of the CP101-606 binding site within the NR2B subtype of the NMDA receptor. The compounds identified do not possess phenolic functional groups such as those in ifenprodil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d39e7b2fa51a028f86ba5dd6fd91511b
https://doi.org/10.1016/j.bmcl.2011.03.117
https://doi.org/10.1016/j.bmcl.2011.03.117
Identification of N-(2-(azepan-1-yl)-2-phenylethyl)-benzenesulfonamides as novel inhibitors of GlyT1
Autor:
Deidre E. Wilkins, Jeffrey G. Varnes, Gerald Jonak, Christopher R. Holmquist, Gaochao Tian, Jeffrey S. Albert, Cristobal Alhambra, Tiffany N. Hoerter, Michael W. Wood, Todd Andrew Brugel, Janet Marie Forst, William Potts, Xia Wang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:4878-4881
A novel series of glycine transporter 1 (GlyT1) inhibitors is described. Scoping of the heterocycle moiety of hit 4-chlorobenzenesulfonamide 1 led to replacement of the piperidine with an azepane for a modest increase in potency. Phenyl sulfonamides
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8403805a07c4a4c264641e15948a1d48
https://doi.org/10.1016/j.bmcl.2010.06.085
https://doi.org/10.1016/j.bmcl.2010.06.085
Autor:
Laura M. Panko, Linda A. Sygowski, Patricia Schroeder, Matthew F. Peters, John C. Gordon, Anna Zacco, Scott Throner, Ruifeng Liu, Michael Balestra, Joseph Cacciola, Angela M. Hunter, James Folmer, Reed W. Smith, Thalia Daniels, Gerard M. Koether, Lee T. Hirata, Tiffany N. Hoerter, Dean G. Brown, Todd Andrew Brugel, Norman C. Ledonne, Mark Pietras, Philip D. Edwards, Christopher Becker
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(19)
Initial high throughput screening efforts identified highly potent and selective kappa opioid receptor antagonist 3 (κ IC50 = 77 nM; μ:κ and δ:κ IC50 ratios >400) which lacked CNS exposure in vivo. Modification of this scaffold resulted in devel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eb0a7172b07cd122fc6d93b09cbe19b
https://pubmed.ncbi.nlm.nih.gov/20727752
https://pubmed.ncbi.nlm.nih.gov/20727752