Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Tiffany M. Styles"'
Autor:
Venkata S. Bollimpelli, Pradeep B. J Reddy, Sailaja Gangadhara, Tysheena P. Charles, Samantha L. Burton, Gregory K. Tharp, Tiffany M. Styles, Celia C. Labranche, Justin C. Smith, Amit A. Upadhyay, Anusmita Sahoo, Traci Legere, Ayalnesh Shiferaw, Vijayakumar Velu, Tianwei Yu, Mark Tomai, John Vasilakos, Sudhir P. Kasturi, George M. Shaw, David Montefiori, Steven E. Bosinger, Pamela A. Kozlowski, Bali Pulendran, Cynthia A. Derdeyn, Eric Hunter, Rama R. Amara
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Route of immunization can markedly influence the quality of immune response. Here, we show that intradermal (ID) but not intramuscular (IM) modified vaccinia Ankara (MVA) vaccinations provide protection from acquisition of intravaginal tier2
Externí odkaz:
https://doaj.org/article/101d7faa095245b791894f88734b70d5
Autor:
Nanda Kishore Routhu, Narayanaiah Cheedarla, Venkata Satish Bollimpelli, Sailaja Gangadhara, Venkata Viswanadh Edara, Lilin Lai, Anusmita Sahoo, Ayalnesh Shiferaw, Tiffany M. Styles, Katharine Floyd, Stephanie Fischinger, Caroline Atyeo, Sally A. Shin, Sanjeev Gumber, Shannon Kirejczyk, Kenneth H. Dinnon, Pei-Yong Shi, Vineet D. Menachery, Mark Tomai, Christopher B. Fox, Galit Alter, Thomas H. Vanderford, Lisa Gralinski, Mehul S. Suthar, Rama Rao Amara
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Efficient vaccines for SARS-CoV-2 are needed. Here, the authors show that a trimeric form of the receptor-binding domain of SARS-CoV-2 spike adjuvanted with alum-3M-052 protects non-human primates from disease and inhibits infection.
Externí odkaz:
https://doaj.org/article/eb5e727593c442beadc6bb289092f047
Autor:
Tiffany M. Styles, Sailaja Gangadhara, Pradeep B. J. Reddy, Anusmita Sahoo, Ayalensh Shiferaw, Sarah Welbourn, Pamela A. Kozlowski, Cynthia A. Derdeyn, Vijayakumar Velu, Rama Rao Amara
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Stabilized HIV envelope (Env) trimeric protein immunogens have been shown to induce strong autologous neutralizing antibody response. However, there is limited data on the immunogenicity and efficacy of stabilized Env expressed by a viral vector-base
Externí odkaz:
https://doaj.org/article/81f9a87b6bff43e3a8a1399b0ad63c82
Autor:
Stella J. Berendam, Ashley N. Nelson, Bhrugu Yagnik, Ria Goswami, Tiffany M. Styles, Margaret A. Neja, Caroline T. Phan, Sedem Dankwa, Alliyah U. Byrd, Carolina Garrido, Rama R. Amara, Ann Chahroudi, Sallie R. Permar, Genevieve G. Fouda
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Early initiation of antiretroviral therapy (ART) significantly improves clinical outcomes and reduces mortality of infants/children living with HIV. However, the ability of infected cells to establish latent viral reservoirs shortly after infection a
Externí odkaz:
https://doaj.org/article/58c873b9fd734cfe843c751bcee74119
Autor:
Sheikh Abdul Rahman, James M. Billingsley, Ashish Arunkumar Sharma, Tiffany M. Styles, Sakthivel Govindaraj, Uma Shanmugasundaram, Hemalatha Babu, Susan Pereira Riberio, Syed A. Ali, Gregory K. Tharp, Chris Ibegbu, Stephen N. Waggoner, R. Paul Johnson, Rafick-Pierre Sekaly, Francois Villinger, Steve E. Bosinger, Rama Rao Amara, Vijayakumar Velu
Publikováno v:
JCI Insight, Vol 7, Iss 8 (2022)
The persistence of virally infected cells as reservoirs despite effective antiretroviral therapy is a major barrier to an HIV/SIV cure. These reservoirs are predominately contained within cells present in the B cell follicles (BCFs) of secondary lymp
Externí odkaz:
https://doaj.org/article/9159c1483082410da6fb0bad4dade201
Autor:
Amudhan Murugesan, Chris Ibegbu, Tiffany M. Styles, Andrew T. Jones, Uma Shanmugasundaram, Pradeep B. J. Reddy, Sadia J. Rahman, Piu Saha, Matam Vijay-Kumar, Esaki Muthu Shankar, Rama Rao Amara, Vijayakumar Velu
Publikováno v:
Frontiers in Immunology, Vol 10 (2020)
Mucosa-associated invariant T (MAIT) cells are recently characterized as a novel subset of innate-like T cells that recognize microbial metabolites as presented by the MHC-1b-related protein MR1. The significance of MAIT cells in anti-bacterial defen
Externí odkaz:
https://doaj.org/article/7980c0808630410eb928227905f75337
Autor:
Steven Tuyishime, Larissa H. Haut, Raj K. Kurupati, James M. Billingsley, Diane Carnathan, Sailaja Gangahara, Tiffany M. Styles, ZhiQuan Xiang, Yan Li, Malte Zopfs, Qin Liu, XiangYang Zhou, Mark G. Lewis, Rama R. Amara, Steven Bosinger, Guido Silvestri, Hildegund C.J. Ertl
Publikováno v:
EBioMedicine, Vol 31, Iss , Pp 25-35 (2018)
We report on prime-boost vaccine regimens with two simian adenovirus (Ad) vectors (SAdV) or two human serotype Ad vectors (HAdV) expressing Gag and gp160 of simian immunodeficiency virus (SIV)mac239 tested in HAdV-seropositive rhesus macaques (RMs) r
Externí odkaz:
https://doaj.org/article/cba17e029b06400699766f31d61b895c
Autor:
Anusmita Sahoo, Andrew T. Jones, Narayanaiah Cheedarla, Sailaja Gangadhara, Vicky Roy, Tiffany M. Styles, Ayalnesh Shiferaw, Korey L. Walter, LaTonya D. Williams, Xiaoying Shen, Gabriel Ozorowski, Wen-Hsin Lee, Samantha Burton, Lasanajak Yi, Xuezheng Song, Zhaohui S. Qin, Cynthia A. Derdeyn, Andrew B. Ward, John D. Clements, Raghavan Varadarajan, Georgia D. Tomaras, Pamela A. Kozlowski, Galit Alter, Rama Rao Amara
Publikováno v:
Sci Immunol
The rising global HIV-1 burden urgently requires vaccines capable of providing heterologous protection. Here, we developed a clade C HIV-1 vaccine consisting of priming with modified vaccinia Ankara (MVA) and boosting with cyclically permuted trimeri
Autor:
Traci Legere, Pradeep B. J. Reddy, Korey A. Walter, Bali Pulendran, Prabhu S. Arunachalam, Shankar Subramaniam, Florian Wimmers, Madeleine K D Scott, Celia C. LaBranche, Bertrand Z. Yeung, John P. Vasilakos, Venkata S. Bollimpelli, Samantha L. Burton, Sailaja Gangadhara, Sudhir Pai Kasturi, Shakti Gupta, Cynthia A. Derdeyn, Caroline Petitdemange, Pamela A. Kozlowski, David C. Montefiori, Tiffany M. Styles, Thomas J. Ketas, John P. Moore, Chil Yong Kang, Rama Rao Amara, Eric Hunter, George M. Shaw, Purvesh Khatri, Mark A. Tomai, Anthony Tsai, David Masopust, Vineet Joag, Clare F. Quarnstrom, Tysheena P. Charles
Publikováno v:
Nature Medicine
Recent efforts toward an HIV vaccine focus on inducing broadly neutralizing antibodies, but eliciting both neutralizing antibodies (nAbs) and cellular responses may be superior. Here, we immunized macaques with an HIV envelope trimer, either alone to
Autor:
Mehul S. Suthar, Sailaja Gangadhara, Shannon Kirejczyk, Vineet D. Menachery, Narayanaiah Cheedarla, Venkata Viswanadh Edara, Sally Shin, Venkata S. Bollimpelli, Stephanie Fischinger, Katharine Floyd, Caroline Atyeo, Anusmita Sahoo, Pei Yong Shi, Kenneth H. Dinnon, Rama Rao Amara, Christopher B. Fox, Thomas H. Vanderford, Lilin Lai, Galit Alter, Lisa E. Gralinski, Tiffany M. Styles, Sanjeev Gumber, Ayalnesh Shiferaw, Mark A. Tomai, Nanda Kishore Routhu
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
There is a great need for the development of vaccines that induce potent and long-lasting protective immunity against SARS-CoV-2. Multimeric display of the antigen combined with potent adjuvant can enhance the potency and longevity of the antibody re