Výsledky vyhledávání - "Tiffany L. Walker"

Autor: Tiffany L Walker, Dorothy A Shannon

Publikováno v: Neonatal network : NN. 36(6)

Pneumopericardium occurs when air accumulates in the pericardial sac surrounding the heart and is one of the rarest forms of air leaks in neonates. Because of various advances in neonatal care, including gentler modes of ventilation, surfactant repla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9e965eb77952d14683eaf54a3dab140
https://pubmed.ncbi.nlm.nih.gov/29185948

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Characterization of Non-Nitrocatechol Pan and Isoform Specific Catechol-O-methyltransferase Inhibitors and Substrates

Publikováno v: ACS Chemical Neuroscience. 3:129-140

Reduced dopamine neurotransmission in the prefrontal cortex has been implicated as causal for the negative symptoms and cognitive deficit associated with schizophrenia; thus, a compound which selectively enhances dopamine neurotransmission in the pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9770c94c8f1b9c6ee1243d503fbc1a52
https://doi.org/10.1021/cn200109w

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Triazine and pyrimidine based ROCK inhibitors with efficacy in spontaneous hypertensive rat model

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 19:6027-6031

The profile of a series of triazine and pyrimidine based ROCK inhibitors is described. An initial binding mode was established based on a homology model and the proposed interactions are consistent with the observed SAR. Compounds from the series are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cc5a6f020505ba7c250b5885d755431
https://doi.org/10.1016/j.bmcl.2009.09.046

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Miniaturized, Ultra-High Throughput Screening of Tyrosine Kinases Using Homogeneous, Competitive Fluorescence Immunoassays

Autor: Tiffany L. Walker, David A. Dunn, James R. Beasley, Paul M. McCoy

Publikováno v: ASSAY and Drug Development Technologies. 2:141-151

Assay miniaturization and the implementation of high-density 1,536-microwell screening increase the speed and efficiency of screening and lead discovery. To serve this need, a platform of miniaturizable assay technologies has been assembled for speci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba7b0ce9b9c883ec97201ef8af7aa95b
https://doi.org/10.1089/154065804323056486

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Evaluation of Compound Interference in Immobilized Metal Ion Affinity-Based Fluorescence Polarization Detection with a Four Million Member Compound Collection

Autor: Douglas S. Auld, James R. Beasley, David A. Dunn, Susan M. Parlato, Tiffany L. Walker, John M. Lehrach

Publikováno v: ASSAY and Drug Development Technologies. 1:455-459

IMAP is a non-separation-based, antibody-independent, FP assay that can be applied to many types of protein kinases and phosphatases. This technology is currently being used in many high-throughput screening campaigns throughout the industry. In this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::796362760b2ff14e3c30a77a4d9ce56c
https://doi.org/10.1089/154065803322163768

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Miniaturization of ultra-high-throughput screening assays into 1536-well format

Autor: Paul M. McCoy, David A. Dunn, James R. Beasley, Tiffany L. Walker

Publikováno v: SPIE Proceedings.

Assay miniaturization and the implementation of high-density 1536 micro-well screening increases the speed and efficiency of screening and lead discovery. To serve this need, a platform of miniaturizable assay technologies has been assembled for spec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2bfa5dcd53e8b69eaadf531563612563
https://doi.org/10.1117/12.472060

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